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Gu R.-Z.,China National Research Institute of Food and Fermentation Industries | Li C.-Y.,PERFECT CHINA CO. | Liu W.-Y.,China National Research Institute of Food and Fermentation Industries | Yi W.-X.,China National Research Institute of Food and Fermentation Industries | Cai M.-Y.,China National Research Institute of Food and Fermentation Industries
Food Research International | Year: 2011

Collagen extracted from Atlantic salmon (Salmo salar L.) skin (which is normally discarded in the process of manufacture) was hydrolyzed with Alcalase and papain, and treated by multistage separation. The salmon skin collagen peptides (SSCP) obtained had high protein content (91.20±1.03%) and low molecular weights, 90.79% of which were less than 1000Da. SSCP was then separated by reversed-phase high performance liquid chromatography. Eleven major fractions were collected and their angiotensin I-converting enzyme (ACE) inhibitory activity was assayed. Fractions 5 and 7 displaying higher ACE inhibitory activity were subjected to mass spectrometer to identify the ACE inhibitory peptides. A total of eleven peptide sequences were identified, and two dipeptides, Ala-Pro and Val-Arg, were selected for further ACE inhibitory activity analysis. The ACE inhibitory activities of Ala-Pro (IC50=0.060±0.001mg/ml) and Val-Arg (IC50=0.332±0.005mg/ml) were found to be approximately 20- and 4-fold higher than that of SSCP (1.165±0.087mg/ml), respectively. © 2011 Elsevier Ltd.

Lv Y.,U.S. Center for Disease Control and Prevention | Huang J.,U.S. Center for Disease Control and Prevention | Cai M.,U.S. Center for Disease Control and Prevention | Li C.,PERFECT CHINA CO. | And 3 more authors.
Food and Function | Year: 2013

This study set out to determine the immunomodulatory effects of a health food high-peptide meal in immunodeficient mice that was induced by either hydrocortisone (HY) or cyclophosphamide (CP). Five separate trials were performed in which animals were randomly divided into 5 groups of 12 mice for each experimental trial. Group 1 served as the vehicle control. Animals assigned to groups 3-5 (dose groups), were each administered once daily with 1.67, 3.33 or 6.67 g kg-1 body weight of a high-peptide meal, respectively, for 30 consecutive days. Animals from groups 2 to 5 that were included in trials 1 to 4, each received an intramuscular administration of HY at 40 mg kg -1 body weight on days 22, 24, 26, 28, 30. Animals from groups 2-5, in trial 5, each received an intraperitoneal administration of CP at 50 mg kg-1 body weight, on days 26 and 27. On day 31, all groups of mice were differentially screened for immunomodulatory activity following the conclusion of the above experiments. In HY-treated mice, the high-peptide meal accelerated the recovery of the phagocytic function of both macrophages and the reticuloendothelial system, and restored NK cell activity. In CP-treated mice, the high-peptide meal promoted a humoral immune response to sheep red blood cells (SRBCs). These results demonstrated the immunomodulatory effects of a high-peptide meal. © 2013 The Royal Society of Chemistry.

Jin M.-R.,Shanghai University of Traditional Chinese Medicine | Jin M.-R.,Shanghai R and nter for Standardization of Chinese Medicines | Xu H.,Shanghai University of Traditional Chinese Medicine | Duan C.-H.,PERFECT CHINA CO. | And 2 more authors.
Natural Product Research | Year: 2015

(Image Presented) Two new flavones neocafhispidulin (1) and 6″-O-acetyl homoplantaginin (2), together with 10 known flavones and 1 polyphenol were isolated from the whole plants of Salvia plebeia. R. Br. Compounds 3 and 4 were reported from this plant for the first time. Their structures were determined by spectral analyses. Compounds 1-13 were evaluated for their anti-tyrosinase and anti-inflammatory activities. The results showed that compounds 1, 5, 8, 10 and 11 exhibited anti-tyrosinase activities, and compounds 3, 4 and 13 showed potential anti-inflammatory activities. © 2015 Taylor & Francis.

Shanghai JiaoTong University and Perfect China Co. | Date: 2013-06-04

A method and a composition for improving gut micro biota structure, selectively increase a first gut microbiota population while simultaneously decrease a second gut micro biota population in a subject. The first gut micro biota population includes a short-chain fatty acid (SCFA)-producing bacterium and the second gut microbiota population includes an endotoxin-producing bacterium.

China National Research Institute Of Food And Fermentation Industries and Perfect China Co. | Date: 2014-10-31

The present invention relates to a functional engineered rice having alcoholism relief and liver protection functions for those drinking alcohol over an extended period of time or drinking alcohol excessively, and preparation method thereof. The engineered rice comprises six starting materials: coarse rice powder, isolated soy protein, kudzu root extract, corn oligopeptide, purple sweet potato powder, and hawthorn extract, and is prepared by: premixing the starting materials; employing a double screw extruder to conduct texturized processing and forming under high temperature and high pressure; and then drying, dedusting and packaging. The coarse cereal components of the engineered rice have the effects of balancing the diet and ensuring nutrition ingestion for those consuming the rice; and the functional factors such as the corn oligopeptide, the kudzu root extract and the like have the functions of enhancing ethanol metabolism inside the body, reducing liver damage, relieving alcoholism and protecting the liver.

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