Peregrine Pharmaceuticals Inc.

Tustin, CA, United States

Peregrine Pharmaceuticals Inc.

Tustin, CA, United States

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Global Cancer Immunotherapy Market & Clinical Trials Outlook 2022 report gives comprehensive insight on clinical and non-clinical developments in the field of cancer immunotherapy. As per report findings, cancer immunotherapy has emerged as the new growth frontier for the pharmaceutical companies involved in the clinical research and development of cancer drugs and therapeutics. Currently there are more than 2000 cancer immunotherapies based drugs/therapies are in clinical pipeline. Majority of these are in preclinical, Phase-I and Phase-II trials. There are 14 cancer vaccine, 44 Cancer monoclonal antibodies, 3 cancer cell therapies and 61 cancer Immunomodulators are commercially available in the market. Pharmaceutical companies are actively engaged in research and development of cancer immunotherapies because of large unmet medical necessities. Investigators are trying to come forth with innovative cancer immunotherapeutic products having high safety and efficacy profiles which are not offered by conventional therapeutics. Higher investments in research and development segment could significantly increase the drug discovery rates which will alleviate the medical condition of cancer patients. Simultaneously, technological advancements are being made due to which development of worthy candidates with high commercialization and pharmacological potential is expected to increase in coming years. Investigators are trying to decipher underlying principle of cancer progression and proliferation. Different cancer indications have different requirements for developing effective therapeutics due to which identification of these factors have become important. This knowledge would be used for developing innovative cancer immunotherapies for various malignancies. Cancer immunotherapeutics based on these discoveries would pave path for market introduction of highly effective therapeutics. Some progress has been made which could be noticed by observing plethora of cancer immunotherapeutics available for different cancer indications. Their clinical pipeline is also developing rapidly and various products are at different stages of clinical trials. They are expected to offer severe competition to presently available cancer therapeutics with modest pharmacological efficacy. Cancer immunotherapies have been used for limited number of malignancies as compared to other drug categories. Mostly hematological malignancies like follicular lymphoma, chronic lymphocytic leukemia and diffuse large B cell non-Hodgkin's lymphoma have remained the focal point. Other cancer indications like melanoma, NSCLC, prostate cancer and RCC have also got cancer immunotherapeutics. Most like, cancer therapeutics in clinical trials would be able to present positive data that will allow them to easily enter in global market. Cancer incidences are escalating rapidly and cancer immuno therapeutics seems to play an important role in offering better medical care to patients. Some of them have received FDA's accelerated approval and breakthrough therapy designation due to their superior pharmacological benefits. It is expected that similar progress would be shown by cancer immunotherapeutics under development for different malignancies. - Competitive Analysis Key Topics Covered: 1. Immunotherapy: Mending Cancer Regimens 1.1 Preface to Cancer Immunotherapy 1.2 Evolution of Cancer Immunotherapy 2. Categorization of Cancer Immunotherapy 2.1 Specific Cancer Immunotherapy 2.1.1 Cancer Vaccines 2.1.2 Monoclonal Antibodies 2.2 Non-Specific Cancer Immunotherapy 2.2.1 Adoptive Cell Transfer Immunotherapy 2.2.2 Immune Checkpoint Inhibitors 3. Fundamentals of Cancer Vaccines 3.1 Prologue of Cancer Vaccines 3.2 Cancer Vaccines in Immunotherapy 3.3 Commercial Aspects of Cancer Vaccines 4. New Era of Monoclonal Antibodies 4.1 Rudiments of Monoclonal Antibodies 4.2 Advents of Monoclonal Antibodies 4.3 Commercial Aspects of Monoclonal Antibodies 5. Trails of T-Cell Therapies 5.1 Adoptive Cell Transfer Technology 5.2 Strategies of Adoptive Cell Transfer 5.3 Commercial Aspects of Adoptive Cell Therapy 6. Aspects of Immune Checkpoint Inhibitors 6.1 Prelude to Immune Checkpoint Inhibitors 6.2 Implications of Immunecheck Point Inhibitors 6.3 Commercial Aspects of Immune Checkpoint Inhibitors 7. Immunomodulators in Cancer Immunotherapy 7.1 Perspective of Immunomodulators 7.2 Clinical Aspects of Immunomodulators 7.3 Commercial Aspects of Immunomodulators 8. Oncolytic Viral Immunotherapy 8.1 Concept to Oncolytic Viruses 8.2 Potential Approaches of Oncolytic Viruses 8.3 Commercial Aspects of Oncolytic Viruses 9. Cytokines in Cancer Immunotherapy 9.1 Fundamentals of Cytokines 9.2 Classification of Cytokines 9.3 Commercial Aspects of Cytokines 10. Interferons in Immunotherapy 10.1 Potentials of Interferons 10.2 Classification of Interferons 10.3 Clinical Applications of Interferons 11. Interleukins in Immunotherapy 11.1 Potentials of Interleukins 11.2 Clinical Applications of Interleukins 12. GM-CSF in Immunotherapy 12.1 Potentials of GM-CSF 12.2 Clinical Applications of GM-CSF 13. Global Economic Evaluations 13.1 Economic Aspects of Cancer Immunotherapy 13.2 Cancer Immunotherapy Cost by Product 14. Market Aspects of Cancer Immunotherapy 14.1 Current Market Trends 14.2 Cancer Immunotherapy Pipeline Overview 15. Global Cancer Immunotherapy Market Dynamics 15.1 Favorable Market Parameters 15.2 Commercialization Challenges 16. Marketed Cancer Cell Therapies Drugs 16.1 Sipuleucel-T (Provenge®) 16.2 T-Lymphocyte Cell Therapy(Immuncell-LC®) 17. Marketed Cancer Cytokines Drugs 17.1 Aldesleukin (Proleukin®) 17.2 Denileukin Diftitox (ONTAK®) 17.3 Interferon Alpha (Multiferon®) 17.4 Interferon Alpha-2a (Roferon-A®) 17.5 Interferon Alpha-2a (Veldona®) 17.6 Interferon Alpha-2a Biosimilar(Inferon/Inmutag) 17.7 Interferon Alpha-2b(Intron® A) 17.8 Interferon Alpha-2b Biosimilar(Bioferon) 17.9 Interferon Alpha-2b Biosimilar (Intalfa®) 17.10 Interferon Alpha-2b Biosimilar 17.11 Interferon-Alpha-n3 (Alferon N®) 17.12 Interferon-Beta-1b (Feron®) 17.13 Interferon-Gamma (Ogamma®) 17.14 Interleukin-2 Biosimilar (Ilcass) 17.15 Teceleukin (Imunace) 18. Marketed Cancer Vaccines 18.1 Bladder Cancer Vaccine (PACIS®) 18.2 Bladder Cancer Vaccine 18.3 BV NSCLC 001 18.4 Dendritic Cell Vaccine (CreaVax-HCC®, CreaVax-PC® & CreaVax-RCC®) 18.5 Human Papillomavirus Vaccine Quadrivalent (Gardasil®/Silgard®) 18.6 Human Papillomavirus Vaccine Recombinant Bivalent (Cervarix®) 18.7 Melanoma Vaccine (MVax®) 18.8 Melanoma Vaccine (Melacine®) 18.9 Racotumomab (Vaxira®) 18.10 Sipuleucel-T (Provenge®) 18.11 Tertomotide (LucaVax) 18.12 Vitespen (Oncophage®) 19. Marketed Cancer Monoclonal Antibodies 19.1 Bevacizumab 19.2 Trastuzumab Emtansine 19.3 Trastuzumab Subcutaneous 19.4 Brentuximab Vedotin 19.5 Catumaxomab 19.6 Ipilimumab 19.7 Nivolumab 19.8 Pembrolizumab 19.9 Pertuzumab 19.10 Rituximab 19.11 Trastuzumab 20. Global Cancer Immunotherapy Market Future Prospects 21. Competitive Landscape 21.1 Abbvie 21.2 Advaxis 21.3 Altor BioScience 21.4 Amgen 21.5 Biogen Idec 21.6 Biogenomics 21.7 Celldex Therapeutics 21.8 Dendreon Corporation 21.9 Eli Lilly 21.10 Expression Genetics 21.11 Galena Biopharma 21.12 Genmab 21.13 Gilead Sciences 21.14 GlaxoSmithKline 21.15 ImmunoCellular Therapeutics 21.16 ImmunoGen 21.17 Inovio Pharmaceuticals 21.18 IRX Therapeutics 21.19 Merck 21.20 NeoStem Oncology 21.21 NewLink Genetics 21.22 Northwest Biotherapeutics 21.23 Novartis 21.24 Peregrine Pharmaceuticals 21.25 Pfizer 21.26 Philogen 21.27 Regulon 21.28 Roche 21.29 Seattle Genetics 21.30 ZymoGenetics For more information about this report visit http://www.researchandmarkets.com/research/5m873c/global_cancer To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/global-cancer-immunotherapy-market--clinical-trials-outlook-report-2017-2022---research-and-markets-300453141.html


Rockville, Maryland-based Rexahn Pharmaceuticals Inc.'s stock finished last Friday's session 882.14% higher at $3.85. A total volume of 636,822 shares was traded. Shares of the Company, which discovers, develops, and commercializes treatments for cancer, have a Relative Strength Index (RSI) of 95.64. On May 04th, 2017, Rexahn Pharma announced financial results for Q1 ended March 31st, 2017. Cash and investments totaled approximately $18.5 million in Q1 2017; research and development expenses were $2.3 million; general and administrative expenses were approximately $1.7 million; and loss from operations was $4.0 million. Visit us today and download your complete report on RNN for free at: On Friday, shares in Tustin, California headquartered Peregrine Pharmaceuticals Inc. ended the session 2.58% higher at $0.61. The stock recorded a trading volume of 895,916 shares. The Company's shares have surged 97.42% in the previous three months. The stock is trading 45.17% above its 200-day moving average. Moreover, shares of Peregrine Pharma, which researches and develops monoclonal antibodies for the treatment of cancer in the US, have an RSI of 49.77. On May 01st, 2017, Avid Bioservices, Inc., a wholly owned subsidiary of Peregrine Pharma, and MilliporeSigma announced that the former will upgrade its Myford clinical and commercial manufacturing facility with multiple Mobius® 2000-liter single-use bioreactors from MilliporeSigma. The new bioreactors, to be installed in mid-2017, provide Avid with the latest technology while expanding the Company's manufacturing capacity. The complimentary research report on PPHM can be accessed at: Morris Plains, New Jersey headquartered Immunomedics Inc.'s shares surged 17.56%, closing the session at $6.36. A total volume of 24.55 million shares was traded, which was above their three months average volume of 3.85 million shares. The stock has gained 8.16% in the last one month, 44.55% over the previous three months, and 73.30% on an YTD basis. Shares of the Company are trading 8.61% and 62.29% above their 50-day and 200-day moving averages, respectively. Additionally, shares of Immunomedics, which focuses on the development of monoclonal antibody-based products for the targeted treatment of cancer, autoimmune disorders, and other diseases, have an RSI of 61.40. On May 05th, 2017, research firm Wells Fargo upgraded the Company's stock rating from 'Market Perform' to 'Outperform'. Register for free on Stock-Callers.com and download the PDF research report on IMMU at: Last Friday at the close, shares in Carmiel, Israel-based Protalix BioTherapeutics Inc. recorded a trading volume of 901,749 shares. The stock ended the session 2.13% lower at $0.92. The Company's shares have advanced 17.95% over the previous three months and 104.44% since the start of this year. The stock is trading above its 200-day moving average by 30.47%. Furthermore, shares of Protalix BioTherapeutics, which focuses on the development and commercialization of recombinant therapeutic proteins based on its proprietary ProCellEx protein expression system in Israel and internationally, have an RSI of 39.67. On April 17th, 2017, research firm Rodman & Renshaw reiterated its 'Buy' rating on the Company's stock with an increase of the target price from $4 a share to $5 a share. On May 01st, 2017, Protalix BioTherapeutics announced that it will report Q1 2017 financial results and provide a corporate update on Wednesday, May 10th, 2017, at 8:30 a.m. ET. The conference call will be broadcast live and available for replay for two weeks under the Events Calendar of the Investors section of the Company's website. 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Dublin, May 01, 2017 (GLOBE NEWSWIRE) -- Research and Markets has announced the addition of the "Global Cancer Immunotherapy Market & Clinical Trials Outlook 2022" report to their offering. Global Cancer Immunotherapy Market & Clinical Trials Outlook 2022 report gives comprehensive insight on clinical and non-clinical developments in the field of cancer immunotherapy. As per report findings, cancer immunotherapy has emerged as the new growth frontier for the pharmaceutical companies involved in the clinical research and development of cancer drugs and therapeutics. Currently there are more than 2000 cancer immunotherapies based drugs/therapies are in clinical pipeline. Majority of these are in preclinical, Phase-I and Phase-II trials. There are 14 cancer vaccine, 44 Cancer monoclonal antibodies, 3 cancer cell therapies and 61 cancer Immunomodulators are commercially available in the market. Pharmaceutical companies are actively engaged in research and development of cancer immunotherapies because of large unmet medical necessities. Investigators are trying to come forth with innovative cancer immunotherapeutic products having high safety and efficacy profiles which are not offered by conventional therapeutics. Higher investments in research and development segment could significantly increase the drug discovery rates which will alleviate the medical condition of cancer patients. Simultaneously, technological advancements are being made due to which development of worthy candidates with high commercialization and pharmacological potential is expected to increase in coming years. Investigators are trying to decipher underlying principle of cancer progression and proliferation. Different cancer indications have different requirements for developing effective therapeutics due to which identification of these factors have become important. This knowledge would be used for developing innovative cancer immunotherapies for various malignancies. Cancer immunotherapeutics based on these discoveries would pave path for market introduction of highly effective therapeutics. Some progress has been made which could be noticed by observing plethora of cancer immunotherapeutics available for different cancer indications. Their clinical pipeline is also developing rapidly and various products are at different stages of clinical trials. They are expected to offer severe competition to presently available cancer therapeutics with modest pharmacological efficacy. Cancer immunotherapies have been used for limited number of malignancies as compared to other drug categories. Mostly hematological malignancies like follicular lymphoma, chronic lymphocytic leukemia and diffuse large B cell non-Hodgkin's lymphoma have remained the focal point. Other cancer indications like melanoma, NSCLC, prostate cancer and RCC have also got cancer immunotherapeutics. Most like, cancer therapeutics in clinical trials would be able to present positive data that will allow them to easily enter in global market. Cancer incidences are escalating rapidly and cancer immuno therapeutics seems to play an important role in offering better medical care to patients. Some of them have received FDA's accelerated approval and breakthrough therapy designation due to their superior pharmacological benefits. It is expected that similar progress would be shown by cancer immunotherapeutics under development for different malignancies. - Competitive Analysis Key Topics Covered: 1. Immunotherapy: Mending Cancer Regimens 1.1 Preface to Cancer Immunotherapy 1.2 Evolution of Cancer Immunotherapy 2. Categorization of Cancer Immunotherapy 2.1 Specific Cancer Immunotherapy 2.1.1 Cancer Vaccines 2.1.2 Monoclonal Antibodies 2.2 Non-Specific Cancer Immunotherapy 2.2.1 Adoptive Cell Transfer Immunotherapy 2.2.2 Immune Checkpoint Inhibitors 3. Fundamentals of Cancer Vaccines 3.1 Prologue of Cancer Vaccines 3.2 Cancer Vaccines in Immunotherapy 3.3 Commercial Aspects of Cancer Vaccines 4. New Era of Monoclonal Antibodies 4.1 Rudiments of Monoclonal Antibodies 4.2 Advents of Monoclonal Antibodies 4.3 Commercial Aspects of Monoclonal Antibodies 5. Trails of T-Cell Therapies 5.1 Adoptive Cell Transfer Technology 5.2 Strategies of Adoptive Cell Transfer 5.3 Commercial Aspects of Adoptive Cell Therapy 6. Aspects of Immune Checkpoint Inhibitors 6.1 Prelude to Immune Checkpoint Inhibitors 6.2 Implications of Immunecheck Point Inhibitors 6.3 Commercial Aspects of Immune Checkpoint Inhibitors 7. Immunomodulators in Cancer Immunotherapy 7.1 Perspective of Immunomodulators 7.2 Clinical Aspects of Immunomodulators 7.3 Commercial Aspects of Immunomodulators 8. Oncolytic Viral Immunotherapy 8.1 Concept to Oncolytic Viruses 8.2 Potential Approaches of Oncolytic Viruses 8.3 Commercial Aspects of Oncolytic Viruses 9. Cytokines in Cancer Immunotherapy 9.1 Fundamentals of Cytokines 9.2 Classification of Cytokines 9.3 Commercial Aspects of Cytokines 10. Interferons in Immunotherapy 10.1 Potentials of Interferons 10.2 Classification of Interferons 10.3 Clinical Applications of Interferons 11. Interleukins in Immunotherapy 11.1 Potentials of Interleukins 11.2 Clinical Applications of Interleukins 12. GM-CSF in Immunotherapy 12.1 Potentials of GM-CSF 12.2 Clinical Applications of GM-CSF 13. Global Economic Evaluations 13.1 Economic Aspects of Cancer Immunotherapy 13.2 Cancer Immunotherapy Cost by Product 14. Market Aspects of Cancer Immunotherapy 14.1 Current Market Trends 14.2 Cancer Immunotherapy Pipeline Overview 15. Global Cancer Immunotherapy Market Dynamics 15.1 Favorable Market Parameters 15.2 Commercialization Challenges 16. Marketed Cancer Cell Therapies Drugs 16.1 Sipuleucel-T (Provenge®) 16.2 T-Lymphocyte Cell Therapy(Immuncell-LC®) 17. Marketed Cancer Cytokines Drugs 17.1 Aldesleukin (Proleukin®) 17.2 Denileukin Diftitox (ONTAK®) 17.3 Interferon Alpha (Multiferon®) 17.4 Interferon Alpha-2a (Roferon-A®) 17.5 Interferon Alpha-2a (Veldona®) 17.6 Interferon Alpha-2a Biosimilar(Inferon/Inmutag) 17.7 Interferon Alpha-2b(Intron® A) 17.8 Interferon Alpha-2b Biosimilar(Bioferon) 17.9 Interferon Alpha-2b Biosimilar (Intalfa®) 17.10 Interferon Alpha-2b Biosimilar 17.11 Interferon-Alpha-n3 (Alferon N®) 17.12 Interferon-Beta-1b (Feron®) 17.13 Interferon-Gamma (Ogamma®) 17.14 Interleukin-2 Biosimilar (Ilcass) 17.15 Teceleukin (Imunace) 18. Marketed Cancer Vaccines 18.1 Bladder Cancer Vaccine (PACIS®) 18.2 Bladder Cancer Vaccine 18.3 BV NSCLC 001 18.4 Dendritic Cell Vaccine (CreaVax-HCC®, CreaVax-PC® & CreaVax-RCC®) 18.5 Human Papillomavirus Vaccine Quadrivalent (Gardasil®/Silgard®) 18.6 Human Papillomavirus Vaccine Recombinant Bivalent (Cervarix®) 18.7 Melanoma Vaccine (MVax®) 18.8 Melanoma Vaccine (Melacine®) 18.9 Racotumomab (Vaxira®) 18.10 Sipuleucel-T (Provenge®) 18.11 Tertomotide (LucaVax) 18.12 Vitespen (Oncophage®) 19. Marketed Cancer Monoclonal Antibodies 19.1 Bevacizumab 19.2 Trastuzumab Emtansine 19.3 Trastuzumab Subcutaneous 19.4 Brentuximab Vedotin 19.5 Catumaxomab 19.6 Ipilimumab 19.7 Nivolumab 19.8 Pembrolizumab 19.9 Pertuzumab 19.10 Rituximab 19.11 Trastuzumab 20. Global Cancer Immunotherapy Market Future Prospects 21. Competitive Landscape 21.1 Abbvie 21.2 Advaxis 21.3 Altor BioScience 21.4 Amgen 21.5 Biogen Idec 21.6 Biogenomics 21.7 Celldex Therapeutics 21.8 Dendreon Corporation 21.9 Eli Lilly 21.10 Expression Genetics 21.11 Galena Biopharma 21.12 Genmab 21.13 Gilead Sciences 21.14 GlaxoSmithKline 21.15 ImmunoCellular Therapeutics 21.16 ImmunoGen 21.17 Inovio Pharmaceuticals 21.18 IRX Therapeutics 21.19 Merck 21.20 NeoStem Oncology 21.21 NewLink Genetics 21.22 Northwest Biotherapeutics 21.23 Novartis 21.24 Peregrine Pharmaceuticals 21.25 Pfizer 21.26 Philogen 21.27 Regulon 21.28 Roche 21.29 Seattle Genetics 21.30 ZymoGenetics For more information about this report visit http://www.researchandmarkets.com/research/rl32xc/global_cancer


Patent
The University Of Texas System and Peregrine Pharmaceuticals Inc. | Date: 2017-01-04

Disclosed are surprising new methods and compositions for isolating extracellular microvesicles such as exosomes, particularly disease-related and phosphatidylserine (PS)-positive extracellular microvesicles as exemplified by tumor- and viral-derived exosomes. The methods of the invention are rapid, efficient, cost-effective and, importantly, are suitable for use with large volumes of biological fluids and produce antigenically intact extracellular microvesicles and exosomes. The methods and compositions are based on the surprising use of acetate buffers to isolate large quantities of extracellular microvesicles, particularly tumor-derived exosomes, from solution, without damaging their morphological or functional properties or antigenicity.


Patent
The University Of Texas System and Peregrine Pharmaceuticals Inc. | Date: 2015-02-27

Disclosed are surprising new methods and compositions for isolating extracellular microvesicles such as exosomes, particularly disease-related and phosphatidylserine (PS)-positive extracellular microvesicles as exemplified by tumor- and viral-derived exosomes. The methods of the invention are rapid, efficient, cost-effective and, importantly, are suitable for use with large volumes of biological fluids and produce antigenically intact extracellular microvesicles and exosomes. The methods and compositions are based on the surprising use of acetate buffers to isolate large quantities of extracellular microvesicles, particularly tumor-derived exosomes, from solution, without damaging their morphological or functional properties or antigenicity.


Patent
The University Of Texas System and Peregrine Pharmaceuticals Inc. | Date: 2015-02-02

Disclosed are new phosphatidylserine binding constructs with surprising combinations of properties, and a range of diagnostic and therapeutic conjugates thereof. The new constructs effectively bind phosphatidylserine targets in disease and enhance their destruction, and can also specifically deliver attached imaging or therapeutic agents to the disease site. Also disclosed are methods of using the new construct compositions, therapeutic conjugates and combinations thereof in tumor vasculature targeting, cancer diagnosis and treatment, and fir treating viral infections and other diseases.


Patent
The University Of Texas System and Peregrine Pharmaceuticals Inc. | Date: 2016-07-12

Disclosed are new phosphatidylserine binding constructs with surprising combinations of properties, and a range of diagnostic and therapeutic conjugates thereof. The new constructs effectively bind phosphatidylserine targets in disease and enhance their destruction, and can also specifically deliver attached imaging or therapeutic agents to the disease site. Also disclosed are methods of using the new construct compositions, therapeutic conjugates and combinations thereof in tumor vasculature targeting, cancer diagnosis and treatment, and for treating viral infections and other diseases.


Patent
Affitech AS and Peregrine Pharmaceuticals Inc. | Date: 2013-07-17

Disclosed are human antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two primary VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet have improved safety due to their specificity. The present invention thus provides new human antibody-based compositions, methods and combined protocols for treating cancer and other angiogenic diseases. Advantageous immunoconjugate compositions and methods using the new VEGF-specific human antibodies are also provided.


Patent
Affitech AS and Peregrine Pharmaceuticals Inc. | Date: 2011-09-06

Disclosed are human antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two primary VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet have improved safety due to their specificity. The present invention thus provides new human antibody-based compositions, methods and combined protocols for treating cancer and other angiogenic diseases. Advantageous immunoconjugate compositions and methods using the new VEGF-specific human antibodies are also provided.


Patent
Peregrine Pharmaceuticals Inc. and Affitech AS | Date: 2013-02-15

Disclosed are human antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two primary VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet have improved safety due to their specificity. The present invention thus provides new human antibody-based compositions, methods and combined protocols for treating cancer and other angiogenic diseases. Advantageous immunoconjugate compositions and methods using the new VEGF-specific human antibodies are also provided.

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