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Chen Y.,Jiangnan University | Lin J.,Peoples Liberation Army 101 Hospital | Fei Y.,Jiangnan University | Wang H.,Jiangnan University | Gao W.,Jiangnan University
Fibers and Polymers | Year: 2010

In this paper, curcumin-loaded electrospinning Poly(lactic acid) (PLA) composite membranes were prepared. Curcumin with different contents (1, 3, and 5 wt%) was loaded to study its anticoagulation property as a drug-eluting stent. The structure of the composite membrane was analyzed by Fourier Transform Infrared (FTIR) spectroscopy, and the results suggested that both PLA and curcumin were present in the composite membrane without chemical reaction between them. Scanning electron microscopy (SEM) and related analysis revealed that the average diameters of composite nanofibers were between 756 and 971 nm with better uniformity in the range of the experiment, furthermore the average diameters of composite nanofibers decreased with the curcumin content increase; The in vitro anticoagulation behavior of curcumin-eluting stents was investigated through static platelet adhesion test, revealing that the anticoagulation property of composite membranes was superior to the pure PLA membrane, and the anticoagulation behavior significantly improved with increasing curcumin by dint of SEM observation. © 2010 The Korean Fiber Society and Springer Netherlands.


Chen Y.,Jiangnan University | Lin J.,Peoples Liberation Army 101 Hospital | Wan Y.,Jiangnan University | Fei Y.,Jiangnan University | And 2 more authors.
Fibers and Polymers | Year: 2012

In this article, curcumin-loaded electrospun Polylactic acid (PLA) composite membranes were prepared. Curcumin with different concentrations (1, 3 and 5 wt%) was loaded to the PLA membranes to study its anticoagulant property as a drug-eluting stent. X-ray diffraction (XRD) characterization of the prepared membranes indicates that PLA and curcumin mix together well through the method of electrospinning and the composite membrane has larger crystallinity than that of PLA membrane. The in vitro blood compatibility of curcumin-eluting stents was investigated by static platelet adhesion and blood coagulation time (APTT and PT) tests, revealing that the blood compatibility of composite membranes is superior to the pure PLA membrane, and the blood compatibility significantly improves with curcumin concentration increasing by dint of observing SEM images and calculating the inhibition rate of platelet aggregation. Moreover, PLA/curcumin membrane can effectively prolong the blood coagulation time compared with the plasma, and the blood coagulation time of composite membranes improves significantly as curcumin concentration increasing. © 2012 The Korean Fiber Society and Springer Science+Business Media Dordrecht.


Xia Y.,Peoples Liberation Army 101 Hospital | Pan G.,Peoples Liberation Army 101 Hospital | Xue F.,Peoples Liberation Army 101 Hospital | Geng C.,Peoples Liberation Army 101 Hospital
Experimental and Therapeutic Medicine | Year: 2013

The aim of this study was to evaluate 64-slice spiral CT image reconstruction of the portal vein in biliary obstruction. A total of 34 clinical patients with biliary obstruction were confirmed by 64-slice spiral CT scanning with portal venous phase multi-planar reconstruction (MPR) of the biliary tract, curved planar reconstruction (CPR), thin-slab minimum-intensity projection (TS-MinIP) and maximum intensity projection (MIP). The reconstructed images were reviewed to further assess the position and cause of the biliary obstruction and to judge the accuracy of diagnosis. The 64-slice spiral CT image reconstruction of the biliary obstructions determined the causes with an accuracy of 88.2% (30/34) and identified the location of the obstruction with an accuracy of 100%. A 64-slice spiral CT reconstructed image of the portal bile duct lesions was generated, which indicated the lesion morphology, location and anatomical relationship with surrounding tissues, secondary biliary stricture and the degree of expansion and is of great clinical value in the characterization and preoperative evaluation of biliary disease.


Xia Y.B.,Peoples Liberation Army 101 Hospital | Pan G.M.,Peoples Liberation Army 101 Hospital | Geng C.J.,Peoples Liberation Army 101 Hospital | Xue F.,Peoples Liberation Army 101 Hospital | Xie Y.Y.,Peoples Liberation Army 101 Hospital
Genetics and Molecular Research | Year: 2015

The objective of the current study was to assess the utility of 64-row helical computed tomography angiography (CTA) in the evaluation of extremity vascular traumas. The extremities from 17 clinical cases of suspected traumatic vascular damage were evaluated using 64-row helical CTA. To evaluate extremity vascular traumas using CTA, volume rendering, multiple planar reconstruction, and curved planar reconstruction technology were applied to accurately and rapidly indicate the type and extent of blood vessel damage, as well as any relationship with injuries to adjacent bones, joints, soft tissue swelling, or hematomas. The types of extremity vascular traumas evaluated included damaged arteries, artery spasms or block, blood vessels shifted because of pressure, pseudo aneurysms, arteriovenous fistula, and vein occlusion. The results of the study indicated that 64-row helical CTA could be highly efficient and accurate in the evaluation of extremity vascular traumas, and could aid in making clinical assessments. © FUNPEC-RP.

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