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Jain S.,VNS Institute of Pharmacy | Patil U.K.,Peoples Institute of Pharmacy and Research Center
Indian Journal of Natural Products and Resources | Year: 2010

Cassia tora Linn. is one of the well-known anthraquinone containing plant and has been used in Chinese and Ayurvedic medicine. In the present review, an attempt has been made to explore a literature survey on its traditional uses, phytochemical studies and pharmacological properties. The whole plant as well as specific parts such as roots, leaves and seeds have been widely used and claimed against different diseases by rural and traditional practitioners of Satpura region of Madhya Pradesh. This plant has great contribution in modern system of herbal medicine for new drug development. Source


Iyer D.,VNS Institute of Pharmacy | Sharma B.K.,VNS Institute of Pharmacy | Patil U.K.,Peoples Institute of Pharmacy and Research Center
Journal of Dietary Supplements | Year: 2013

The present study was undertaken to explore the antihyperlipidemic effect of ethanolic extract of rhizomes of Alpinia galanga L. and its chloroform fraction in Triton-induced hyperlipidemic rats. Bioactivity guided fractionation was followed by chromatographic studies. Flash chromatography was done for the most active fraction resulting in the isolation of 5-(hydroxymethyl) furfural. Animals were administered with i.p. injection of Triton WR 1339 at dose of 400 mg/kg body weight. After 24 hr of Triton administration, the ethanolic extract and its fraction were administered orally at doses of 200 and 400 mg/kg body weight in rats. The treatment was continued for 5 days with a view to see the effect on lipid profile. Serum samples were subjected to biochemical analysis. The study dose dependently inhibited the total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL) level, and significantly increased high-density lipoprotein (HDL) level. Phytochemical screening revealed the presence of tannins, coumarins, flavanoids, sterols, and glycosides. Phytochemical investigation of the chloroform fraction of A. galanga L. resulted in the isolation of 5-(hydroxymethyl) furfural. UV λmax was found to be 276 nm for the isolated component. Acute treatment caused a stimulatory effect on the HDL level and inhibition in TC and TG elevation induced by triton. © 2013 Informa Healthcare USA, Inc. Source


Iyer D.,Vidya Niketan Samiti Institute of Pharmacy | Patil U.K.,Peoples Institute of Pharmacy and Research Center
Chinese Journal of Integrative Medicine | Year: 2014

Objective To explore the anti-hyperlipidemic and anti-tumor effect of ethanolic extract of Evolvulus alsinoides, its chloroform fraction and isolated components in Triton-induced hyperlipidemic rats. Methods Animals were administered with intraperitoneal (i.p.) injection of Triton WR 1339 at a dose of 400 mg/kg body weight. After 24 h of Triton administration the test drugs were administered orally at a dose of 200 mg/kg body weight in rats. The ethanolic extract and stigmast-5-en-3β-ol from Evolvulus alsinoides were further investigated for the tumor take inhibitory activity in hybrid mice (of C57BL strain + Swiss albino strain). Preventive group animals were injected daily with the extract and stigmast-5-en-3β-ol at dose of 50 mg/kg body weight i.p. for 10 consecutive days. The animals were observed for the growth of tumor after injection of B16F10 melanoma cells into the dorsal skin of mice. Results Stigmast-5-en-3β-ol showed a marked antihyperlipidemic potential by reducing the total cholesterol, triglycerides, low density lipoproteins level, and significantly increased high density lipoprotein level compared with other isolated component. Pretreatment with the drug showed delay tumor growth by increasing the volume doubling time and growth delay. The stigmast-5-en-3β-ol showed better mean survival time. Conclusion The supplementation of antioxidants and phytosterols rich food Evolvulus alsinoides has significant tumor take inhibitory activity. © 2014 Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg. Source


Iyer D.,VNS Institute of Pharmacy | Patil U.K.,Peoples Institute of Pharmacy and Research Center
Asian Pacific Journal of Tropical Disease | Year: 2012

Objective: To explore the Anti-hyperlipidemic and Anti-tumor effect of ethanolic extract, chloroform fraction and stigmast-5-en-3β-ol from stems of Salvadora persica L. Methods: The antihyperlipidemic effect of ethanolic extract of Salvadora persica, its chloroform fraction and isolated components was evaluated in Triton- induced hyperlipidemic rats. Animals were administered with i.p. injection of Triton WR 1339 at dose of 400 mg/kg body weight. After 24 h. of Triton administration the test drugs were administered orally at doses of 200 mg/kg body weight in rats. The ethanolic extract and stigmast-5-en-3β-ol from Salvadora persica were further investigated for the tumor take inhibitory activity in hybrid mice (of C57BL strain + Swiss albino strain). Preventive group animals were injected daily with the extract and Stigmast-5-en-3β-ol at dose of 50mg/kg body weight i.p. for 10 consecutive days. The animals were observed for the growth of tumor after injection of B16F10 melanoma cells into the dorsal skin of mice. Results: Phytochemical investigation of stems of Salvadora persica resulted in the isolation of stigmast-5-en-3β-ol. The structure of the component has been established on the basis of spectral data analysis. UV λ max was found to be 206 nm with a melting point of 138°C for the isolated component. The stigmast-5-en-3β-ol showed inhibition of total cholesterol, triglycerides, low density lipoproteins level (LDL), and significantly increased high density lipoprotein level (HDL) in Triton- induced hyperlipidemic rats. It suggested marked antihyperlipidemic activity of stigmast-5-en-3β-ol at the oral dose of 200mg/kg. Pretreatment with the drug showed delay tumor growth by increasing the Volume Doubling Time (VDT) and Growth Delay (GD). The Stigmast-5-en-3β-ol had shown better mean survival time. Conclusions: These observations enabled to conclude that supplementation of antioxidants and phytosterols rich food exerts significant antihyperlipidemic and antitumor activity. The present investigation may be quite useful as this drug is highly valued as traditional system of medicine. © 2012 Asian Pacific Tropical Medicine Press. Source


Patil U.K.,Peoples Institute of Pharmacy and Research Center
Indian Journal of Natural Products and Resources | Year: 2011

The aim of this study was to evaluate anthelmintic efficacy of the Prosopis cineraria (Linn.) Druce bark. Petroleum ether, methanolic and aqueous extracts of the bark were evaluated separately for anthelmintic activity on adult Indian earthworm Pheretima posthuma, using albendazole as reference standard. Time required for the paralysis and death was noted. The results indicated that the methanolic extract was more potent than the petroleum ether and aqueous extract. Source

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