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Patil U.K.,Peoples Institute of Pharmacy and Research Center
Indian Journal of Natural Products and Resources | Year: 2011

The aim of this study was to evaluate anthelmintic efficacy of the Prosopis cineraria (Linn.) Druce bark. Petroleum ether, methanolic and aqueous extracts of the bark were evaluated separately for anthelmintic activity on adult Indian earthworm Pheretima posthuma, using albendazole as reference standard. Time required for the paralysis and death was noted. The results indicated that the methanolic extract was more potent than the petroleum ether and aqueous extract.


Qureshi S.S.,GLA University | Gupta J.K.,GLA University | Shah K.,GLA University | Upmanyu N.,Peoples Institute of Pharmacy and Research Center
Asian Journal of Pharmaceutical and Clinical Research | Year: 2016

Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women. Its clinical manifestation varies from mild to severe disturbance of reproductive and metabolic functions. PCOS is clinical and public health importance because it is affecting up to one in five women of reproductive age. It is an X-linked dominant condition and has diverse clinical implications such as psychological features (anxiety, depression), reproductive features (hirsutism and hyperandrogenism), and impaired glucose tolerance. It is widely dependent on environmental, genetic, ethnicity factors including lifestyle and body weight. Weight loss improves the endocrine profile and increases chances of ovulation and pregnancy. It can be treated with medications such as clomiphene citrate, tamoxifen, aromatase inhibitors, and gonadotrophins. The last option for fertilization is in vitro fertilization when other treatment fails. Its prevalence is estimated at 4-8% from studies performed in Spain and USA. Lifestyle including diet, exercise, and behavior therapy improves fertility. PCOS has unique interactions with the ever increasing obesity prevalence worldwide as obesity-induced insulin resistance significantly aggravates all the features of PCOS. Education about how PCOS affects long-term health should be provided to women with this disorder to feel physical and psychological benefits so that they could engage themselves more with their health care providers. © 2016, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.


Rambhade S.,Peoples Institute of Pharmacy and Research Center | Chakarborty A.,Peoples Institute of Pharmacy and Research Center | Shrivastava A.,Peoples Institute of Pharmacy and Research Center | Patil U.K.,Peoples Institute of Pharmacy and Research Center | And 2 more authors.
Toxicology International | Year: 2012

In the past, polypharmacy was referred to the mixing of many drugs in one prescription. Today polypharmacy implies to the prescription of too many medications for an individual patient, with an associated higher risk of adverse drug reactions (ADRs) and interactions. Situations certainly exist where the combination therapy or polytherapy is the used for single disease condition. Polypharmacy is a problem of substantial importance, in terms of both direct medication costs and indirect medication costs resulting from drug-related morbidity. Polypharmacy increases the risk of side effects and interactions. Moreover it is a preventable problem. A retrospective study was carried out at Bhopal district (Capital of Madhya Pradesh, India) in the year of September-November 2009 by collecting prescriptions of consultants at various levels of health care. The tendency of polypharmacy was studied and analyzed under the various heads in the survey. Available data suggests that polypharmacy is a widespread problem, and physician, clinical pharmacists and patients are all responsible. These risks can be minimized through identifying the prevalence of this potential problem in a high-risk population and by increasing awareness among patients and healthcare professionals. Physicians and clinical pharmacists have the potential to combating this problem through a variety of interventions such as reducing the number of medications taken, reducing the number of doses taken, increasing patient adherence, preventing ADRs, improving patient quality of life and decreasing facility and drug costs.


Iyer D.,Institute of Pharmacy and Research Center | Patil U.K.,Peoples Institute of Pharmacy and Research Center
Pharmaceutical Biology | Year: 2014

Context. Salvadora indica Wight (Salvadoraceae) contains a number of medically beneficial properties including abrasives, astringents and antiseptics. Traditionally, it was used by ancient Arabs to whiten and polish teeth. Objective: This study explores the antihyperlipidemic and antitumor effects of an ethanol extract of S. indica and its isolated phytoconstituents in rodents. Material and methods: Flash chromatography was used for the isolation of phytoconstituents from the stems of S. indica. An antihyperlipidemic study was carried out in Triton loaded rats. Animal groups were given intraperitoneal (i.p.) injection of Triton WR 1339 at dose of 400mg/kg body weight (b.w.). Furthermore, antitumor activity was investigated in hybrid mice (of C57BL strain+Swiss albino strain). The animals were observed for tumor growth after injection of B16F10 melanoma cells into the dorsal skin of mice. Results: The stems of S. indica yielded xanthotoxin and umbelliferone through chromatographic separation techniques. The structures of the compounds were elucidated by spectroscopic data interpretation and showed antihyperlipidemic activity. The study showed significant reduction in total cholesterol (TC) (p<0.01), triglycerides (TGs) (p<0.001), low-density lipoproteins (p<0.01) level whereas increased in high-density lipoprotein (p<0.01) at a significant level, after the treatment. Pretreatment with the extract and phytoconstituents also showed delayed tumor growth by increasing the volume doubling time (VDT) (p<0.01), growth delay (GD) (p<0.01) and mean survival time (p<0.001). Discussion and conclusion: Acute treatment caused a stimulatory effect on high density lipoprotein level and inhibition in TC and TG elevation induced by Triton. Tumor regression studies showed a regression response for tumor growth in vivo of murine mouse melanoma as demonstrated by increasing the VDT and GD. © 2014 Informa Healthcare USA, Inc.


Iyer D.,VNS Institute of Pharmacy | Sharma B.K.,VNS Institute of Pharmacy | Patil U.K.,Peoples Institute of Pharmacy and Research Center
Journal of Dietary Supplements | Year: 2013

The present study was undertaken to explore the antihyperlipidemic effect of ethanolic extract of rhizomes of Alpinia galanga L. and its chloroform fraction in Triton-induced hyperlipidemic rats. Bioactivity guided fractionation was followed by chromatographic studies. Flash chromatography was done for the most active fraction resulting in the isolation of 5-(hydroxymethyl) furfural. Animals were administered with i.p. injection of Triton WR 1339 at dose of 400 mg/kg body weight. After 24 hr of Triton administration, the ethanolic extract and its fraction were administered orally at doses of 200 and 400 mg/kg body weight in rats. The treatment was continued for 5 days with a view to see the effect on lipid profile. Serum samples were subjected to biochemical analysis. The study dose dependently inhibited the total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL) level, and significantly increased high-density lipoprotein (HDL) level. Phytochemical screening revealed the presence of tannins, coumarins, flavanoids, sterols, and glycosides. Phytochemical investigation of the chloroform fraction of A. galanga L. resulted in the isolation of 5-(hydroxymethyl) furfural. UV λmax was found to be 276 nm for the isolated component. Acute treatment caused a stimulatory effect on the HDL level and inhibition in TC and TG elevation induced by triton. © 2013 Informa Healthcare USA, Inc.


Jain S.,VNS Institute of Pharmacy | Patil U.K.,Peoples Institute of Pharmacy and Research Center
Indian Journal of Natural Products and Resources | Year: 2010

Cassia tora Linn. is one of the well-known anthraquinone containing plant and has been used in Chinese and Ayurvedic medicine. In the present review, an attempt has been made to explore a literature survey on its traditional uses, phytochemical studies and pharmacological properties. The whole plant as well as specific parts such as roots, leaves and seeds have been widely used and claimed against different diseases by rural and traditional practitioners of Satpura region of Madhya Pradesh. This plant has great contribution in modern system of herbal medicine for new drug development.


Iyer D.,Vidya Niketan Samiti Institute of Pharmacy | Patil U.K.,Peoples Institute of Pharmacy and Research Center
Chinese Journal of Integrative Medicine | Year: 2014

Objective To explore the anti-hyperlipidemic and anti-tumor effect of ethanolic extract of Evolvulus alsinoides, its chloroform fraction and isolated components in Triton-induced hyperlipidemic rats. Methods Animals were administered with intraperitoneal (i.p.) injection of Triton WR 1339 at a dose of 400 mg/kg body weight. After 24 h of Triton administration the test drugs were administered orally at a dose of 200 mg/kg body weight in rats. The ethanolic extract and stigmast-5-en-3β-ol from Evolvulus alsinoides were further investigated for the tumor take inhibitory activity in hybrid mice (of C57BL strain + Swiss albino strain). Preventive group animals were injected daily with the extract and stigmast-5-en-3β-ol at dose of 50 mg/kg body weight i.p. for 10 consecutive days. The animals were observed for the growth of tumor after injection of B16F10 melanoma cells into the dorsal skin of mice. Results Stigmast-5-en-3β-ol showed a marked antihyperlipidemic potential by reducing the total cholesterol, triglycerides, low density lipoproteins level, and significantly increased high density lipoprotein level compared with other isolated component. Pretreatment with the drug showed delay tumor growth by increasing the volume doubling time and growth delay. The stigmast-5-en-3β-ol showed better mean survival time. Conclusion The supplementation of antioxidants and phytosterols rich food Evolvulus alsinoides has significant tumor take inhibitory activity. © 2014 Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg.


Iyer D.,VNS Institute of Pharmacy | Patil U.K.,Peoples Institute of Pharmacy and Research Center
Asian Pacific Journal of Tropical Disease | Year: 2012

Objective: To explore the Anti-hyperlipidemic and Anti-tumor effect of ethanolic extract, chloroform fraction and stigmast-5-en-3β-ol from stems of Salvadora persica L. Methods: The antihyperlipidemic effect of ethanolic extract of Salvadora persica, its chloroform fraction and isolated components was evaluated in Triton- induced hyperlipidemic rats. Animals were administered with i.p. injection of Triton WR 1339 at dose of 400 mg/kg body weight. After 24 h. of Triton administration the test drugs were administered orally at doses of 200 mg/kg body weight in rats. The ethanolic extract and stigmast-5-en-3β-ol from Salvadora persica were further investigated for the tumor take inhibitory activity in hybrid mice (of C57BL strain + Swiss albino strain). Preventive group animals were injected daily with the extract and Stigmast-5-en-3β-ol at dose of 50mg/kg body weight i.p. for 10 consecutive days. The animals were observed for the growth of tumor after injection of B16F10 melanoma cells into the dorsal skin of mice. Results: Phytochemical investigation of stems of Salvadora persica resulted in the isolation of stigmast-5-en-3β-ol. The structure of the component has been established on the basis of spectral data analysis. UV λ max was found to be 206 nm with a melting point of 138°C for the isolated component. The stigmast-5-en-3β-ol showed inhibition of total cholesterol, triglycerides, low density lipoproteins level (LDL), and significantly increased high density lipoprotein level (HDL) in Triton- induced hyperlipidemic rats. It suggested marked antihyperlipidemic activity of stigmast-5-en-3β-ol at the oral dose of 200mg/kg. Pretreatment with the drug showed delay tumor growth by increasing the Volume Doubling Time (VDT) and Growth Delay (GD). The Stigmast-5-en-3β-ol had shown better mean survival time. Conclusions: These observations enabled to conclude that supplementation of antioxidants and phytosterols rich food exerts significant antihyperlipidemic and antitumor activity. The present investigation may be quite useful as this drug is highly valued as traditional system of medicine. © 2012 Asian Pacific Tropical Medicine Press.


Sharma B.K.,VNS Institute of Pharmacy | Iyer D.,VNS Institute of Pharmacy | Patil U.K.,Peoples Institute of Pharmacy and Research Center
Journal of Herbs, Spices and Medicinal Plants | Year: 2012

The antihyperlipidemic effect of ethanolic extract of seeds of Solanum nigrum L. and its chloroform fraction was explored in Triton induced hyperlipidemic rats. Bioactivity guided fractionation followed by flash chromatography of the most active fraction resulted in the isolation of Stigmast-5, 22-dien-3β-ol. After 24 h of i.p. injection of Triton administration at 400 mg. kg-1b.w., the extract and fraction were administered orally at doses of 200 and 400 mg. kg-1 b.w. Serum samples analyzed showed a dose dependent inhibition of the total cholesterol (TC), triglycerides (TG), low density lipoproteins (LDL) and increased high density lipoprotein (HDL) level. Copyright © Taylor & Francis Group, LLC.


Kapoor R.,Peoples Institute of Pharmacy and Research Center | Patil U.K.,Peoples Institute of Pharmacy and Research Center
International Food Research Journal | Year: 2011

Omega-3 fatty acids are essential polyunsaturated fatty acids that must be obtained through food. The review includes the details of Omega-3 PUFA their importance to humans. Omega-3 PUFA concentrates provide a useful alternative for the intake of required amount of fatty acids. The production techniques for Omega-3 concentrates have been extensively discussed with their advantages and application. Also an insight has been provided for improvement of the shortcomings of these production techniques. With growing public awareness of the health benefits of Omega-3 fatty acids, this market is expected to grow in near future. This overview provides a discussion of the various health benefits, production techniques and their application for commercial production. The review also discusses plant sources as a good source of Omega-3 fatty acids which must be exploited. © 2011.

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