Peoples Hospital of Zunhua City

Tangshan, China

Peoples Hospital of Zunhua City

Tangshan, China
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Zhao G.F.,Tangshan Xiehe Hospital | Hu Y.H.,Tangshan Xiehe Hospital | Liu R.L.,University of Science and Technology of China | Shi F.,Tangshan Xiehe Hospital | And 3 more authors.
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | Year: 2016

OBJECTIVE: To explore the effect of preoperative neutrophil lymphocyte ratio (NLR) on the prognosis of patients with laryngeal carcinoma.METHODS: Clinical data of 202 patients with laryngeal carcinoma treated from January 2004 to October 2009 were retrospective analyzed to determine the optimal critical value of NLR. To study whether NLR is an independent factor affecting the recurrence and 5-year survival rate of patients with laryngeal cancer after surgery, single factor and multivariate analyses were performed. The factors included age, gender, T stage, pathological differentiation, lymph node metastasis, primary tumor site and NLR value. The relationship between NLR and cervical lymph node metastasis was analyzed.RESULTS: The optimal critical value of NLR was 2.85, by which cases were divided into high NLR group (NLR≥2.85) and low NLR group (NLR<2.85). Single factor and multivariate analyses indicated that T staging, lymph node metastasis, primary tumor location, and NLR were the independent factors affecting the recurrence of laryngeal carcinoma. T stage and lymph node metastasis were the independent factors affecting 5-year survival rate of laryngeal carcinoma. The increase of NLR value increased the rate of cervical lymph node metastasis.CONCLUSION: Preoperative NLR level influences the recurrence and cervical lymph node metastasis of laryngeal carcinoma and can be considered a prognosis factor of laryngeal cancer.


Lu F.,Peoples Hospital of Zunhua City | Zhang H.-T.,Peoples Hospital of Zunhua City | Ma S.-Y.,Peoples Hospital of Zunhua City
Chinese Journal of Tissue Engineering Research | Year: 2013

Background: Polyanhydride material is characteristics of surface erosion, biodegradability and release rate adjustability, and it has been approved by the U.S. Food and Drug Administration for human drug carrier materials. Objective: To prepare gatifloxa-poly(sebacic anhydride) local control release system and study its biocompatibility. Methods: Poly(sebacic anhydride) was prepared with melt phase polycondensation method, and mixed with gatifloxacin in the agate mortar to make a local drug delivery system at 20% drug loading. Six rabbits were used to study the biocompatibility of poly(sebacic anhydride) and their back skin was cut open. Six rabbits were randomly divided into two groups, the experimental group was implanted with poly(sebacic anhydride) stick into the paraspinal muscle pouch, while the control group received no implants. Rabbits were killed at 5 weeks post-surgery, and changes on subcutaneous tissue and muscle tissue were observed, as well heart, liver, kidney, and lung. Results and Conclusion: Poly(sebacic anhydride) has a good biocompatibility. After implantation, no rabbit appeared to have the change of appetite and behavior. There was no edema, hemorrhage and erosion at the implanted site, and the surface of implanted materials was porous, which suggested that the materials had been degraded and absorbed subcutaneously. In addition, embrittlement and disintegration were not observed; the implanted materials slightly adhered to surrounding tissue. There was no change in the liver, kidney, lung, heart and partial musculature. Gatifloxacin-poly(sebacic anhydride) local sustained release preparation is well histocompatible with no toxicity and teratogenic action.


Lu F.,Peoples Hospital of Zunhua City | Yan X.-Z.,Peoples Hospital of Zunhua City | Ma S.-Y.,Peoples Hospital of Zunhua City | Zhang H.-T.,Peoples Hospital of Zunhua City
Chinese Journal of Tissue Engineering Research | Year: 2014

BACKGROUND: Polyanhydride materials characterized as surface corrosion resistance, biodegradability and adjustable release rate have been used as drug delivery materials for the body, but the application of polysebacic anhydride delivery system has been rarely reported. OBJECTIVE: To study the role of gatifloxa-polysebacic anhydride local delivery system in the prevention of osteomyelitis in rabbits. METHODS: According to Norden method, we made Staphylococcus aureus-induced osteomyelitis models in the femur of 30 rabbits. There were three groups in the study, 10 rats in each group. Gatifloxa-polysebacic anhydride local delivery system and gatifloxa were respectively used in comparison with model group. After modeling, general observation, anatomical observation, X-ray examination, bone culture and bacteria counting, and histological examination were performed. RESULTS AND CONCLUSION: After 8 weeks, animals in the model group presented with poor appetite, rough fur, and weight loss. Among these 10 rabbits, 3 rabbits died within 3 weeks, and another 7 rabbits appeared to have severe periosteal reactions on the X-ray films, that is, abscess formation shown in the anatomical examination and visible manifestation of osteomyelitis through bone culture and histological examination. In the gatifloxa group, two rabbits died within 3 weeks, abscess formation was found in four rabbits, and periosteal reactions were mild without bone sequestration. Six of 10 rabbits in the gatifloxa appeared to have manifestation of osteomyelitis. In the delivery system group, the animals had a good general state of health and no abnormality was found in the anatomical examination, X-ray examination, bone culture and bacteria count, and histological examination. These findings indicate that the gatifloxa-polysebacic anhydride local sustained release preparation could effectively prevent osteomyelitis.


PubMed | Tangshan Xiehe Hospital, University of Science and Technology of China and Peoples Hospital of Zunhua City
Type: Journal Article | Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | Year: 2016

To explore the effect of preoperative neutrophil lymphocyte ratio (NLR) on the prognosis of patients with laryngeal carcinoma.Clinical data of 202 patients with laryngeal carcinoma treated from January 2004 to October 2009 were retrospective analyzed to determine the optimal critical value of NLR. To study whether NLR is an independent factor affecting the recurrence and 5-year survival rate of patients with laryngeal cancer after surgery, single factor and multivariate analyses were performed. The factors included age, gender, T stage, pathological differentiation, lymph node metastasis, primary tumor site and NLR value. The relationship between NLR and cervical lymph node metastasis was analyzed.The optimal critical value of NLR was 2.85, by which cases were divided into high NLR group (NLR2.85) and low NLR group (NLR<2.85). Single factor and multivariate analyses indicated that T staging, lymph node metastasis, primary tumor location, and NLR were the independent factors affecting the recurrence of laryngeal carcinoma. T stage and lymph node metastasis were the independent factors affecting 5-year survival rate of laryngeal carcinoma. The increase of NLR value increased the rate of cervical lymph node metastasis.Preoperative NLR level influences the recurrence and cervical lymph node metastasis of laryngeal carcinoma and can be considered a prognosis factor of laryngeal cancer.

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