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Wang Q.,Peoples Hospital of Xiangtan County | Dong J.,Institute of Pediatric Research | Zhu Y.,Children Hospital of Hunan Province
Journal of Pediatric Surgery | Year: 2012

Purpose: Necrotizing enterocolitis (NEC) is the most common acquired disease of the gastrointestinal tract in preterm infants, whereas probiotic supplementation might reduce NEC risk and potentially provide benefits to preterm infants. We performed an updated meta-analysis of all relevant randomized, controlled trials to assess the benefits of probiotic supplementation for preterm very low-birth-weight (VLBW) infants. Methods: We searched in PubMed, Embase, and Chinese BioMedical Literature Database (CBM) databases, and 20 randomized, controlled trials (a total of 3816 preterm VLBW infants) were finally included into this meta-analysis. Incidence and relative risk (RR) were calculated using a random-effects or fixed-effects model depending on the heterogeneity of the included studies. Results: Probiotic supplement was associated with a significantly decreased risk of NEC in preterm VLBW infants (RR = 0.33; 95% confidence interval [CI], 0.24-0.46; P <.00001). Risk of death was also significantly reduced in the probiotic group (RR = 0.56; 95% CI, 0.43-0.73; P <.0001). There was no difference in the risk of sepsis between the probiotic group and placebo group (RR = 0.90; 95% CI, 0.71-1.15; P =.40). Conclusions: Probiotic supplement can reduce risk of NEC and mortality in preterm VLBW infants. However, the optimum type of probiotic supplement and the long-term effects need further study. © 2012 Elsevier Inc. All rights reserved. Source


Tan Z.-D.,Hunan Institute of Engineering | Tan F.-J.,Peoples Hospital of Xiangtan County | Tan B.,Peoples Hospital of Xiangtan County | Yi Z.-W.,Hunan Institute of Engineering
Acta Crystallographica Section E: Structure Reports Online | Year: 2011

In the title compound, [Zn(CH 3CO 2) 2(C 8H 7N 3)] n , the Zn II atom is coordinated by one N atom from a 4-(1H-pyrazol-3-yl)pyridine ligand and three O atoms from two bridging and one terminal acetate ligands, forming a distorted tetrahedral geometry. The bridging acetate ligands link the Zn atoms into a chain along [001]. N - H⋯O hydrogen bonds and π-π interactions between the pyridine and pyrazole rings [centroid-centroid distance = 3.927 (3) Å] connect the chains into a layer parallel to (011). © Tan et al. 2011. Source


Tan Z.-D.,Hunan Institute of Engineering | Tan F.-J.,Peoples Hospital of Xiangtan County | Tan B.,Peoples Hospital of Xiangtan County | Zhang C.-M.,Hunan Institute of Engineering
Acta Crystallographica Section E: Structure Reports Online | Year: 2012

In the title complex, [Zn(C2O4)(C2H 6O2)]n, the ZnII ion is in a distorted octahedral environment formed by two O atoms from an ethylene glycol molecule and four O atoms from two oxalate anions. The oxalate anions link the ZnII ions, forming a zigzag chain along [010]. The zigzag chains are extended into a three-dimensional network by O - H⋯O hydrogen bonds. © 2012 International Union of Crystallography. Source


Tan Z.-D.,Hunan Institute of Engineering | Tan F.-J.,Peoples Hospital of Xiangtan County | Tan B.,Peoples Hospital of Xiangtan County | Zhang C.-M.,Hunan Institute of Engineering
Acta Crystallographica Section E: Structure Reports Online | Year: 2012

In the title compound, 2C8H7N3· C8H6O4·2H2O, the pyridine and pyrazole rings are approximately coplanar, the dihedral angle between them being 4.69 (9)°. The asymmetric unit consists of half of the terephthalic acid (an inversion centre generates the other half of the molecule), one 4-(1H-pyrazol-3-yl)pyridine (4pp) molecule and one water molecule. In the crystal, two 4pp and one terephthalic acid molecules form a linear three-molecule unit as a result of O - H⋯N hydrogen bonds. These units are further assembled into a three-dimensional network by two types of hydrogen bonds, viz. O - H⋯O and N - H⋯O. Source


Tan Z.-D.,Hunan Institute of Engineering | Tan F.-J.,Peoples Hospital of Xiangtan County | Tan B.,Peoples Hospital of Xiangtan County | Zhang C.-M.,Hunan Institute of Engineering
Acta Crystallographica Section E: Structure Reports Online | Year: 2011

In the title compound, [ZnCl 2(C 8H 7N 3) 2], the Zn II cation is coordinated by two Cl - anions and two 4-(1H-pyrazol-3-yl)pyridine ligands in a distorted tetra-hedral geometry. In the two 4-(1H-pyrazol-3-yl)pyridine ligands, the dihedral angles between the pyrazole and pyridine rings are 3.3 (3) and 13.3 (3)°. intermolecular N-H⋯N and N-H⋯Cl hydrogen bonding is present in the crystal structure. Source

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