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Gong S.-F.,Shenzhen University | Wang X.-B.,Shenzhen University | Liao Y.-Q.,Shenzhen University | Jiang T.-P.,Shenzhen University | And 5 more authors.
European Review for Medical and Pharmacological Sciences | Year: 2015

OBJECTIVE: To summarize the clinical features of ruptured cerebellar arteriovenous malformations (AVMs) and to explore surgical methods and outcomes in ruptured cerebellar AVM patients. PATIENTS AND METHODS: In the past 14 years, 67 patients with cerebellar AVMs were treated at our institution, accounting for 14.9% of the total vascular malformation patients in our department. In this study, we retrospectively analyzed the clinical characteristics, operation indication, surgery techniques, and prognoses of these cases. RESULTS: Among the 67 AVM cases, the distribution of Spetzler-Martin grades was 32 Grade I, 14 Grade II, 13 Grade III, 5 Grade IV, and 3 Grade V cases. Microsurgical treatment was carried out via the retrosigmoid approach or suboccipital midline approach. After the surgery, the distribution of GOS grades was 60 Grade V, 3 Grade IV, 1 Grade III, 2 Grade II, and 2 Grade I cases. CONCLUSIONS: Microsurgical removal should be performed in ruptured cerebellar AVM patients as early as possible once the preoperative and postoperative preparations were done. Good surgical effects were obtained by using proper surgery techniques and the right protection of critical cerebral structures. Patients with a GCS grade of ≥8 showed good recovery, but patients with a grade of < 8 had poor prognoses.

Gao S.,Jilin University | Ma Q.,Jilin University | Cui Q.,Jilin University | Liu L.,Jilin University | And 4 more authors.
Nuclear Science and Techniques | Year: 2013

The 99mTc-3PRGD2 targeted SPECT/CT scanning was of significance in detecting differentiated glioma. In this work, the diagnostic value of 99mTc-3PRGD2 scintigraphy in brain glioma was evaluated by the ten clinically verified brain glioma patients after obtaining informed consent. The patients first accepted X-ray imaging to localize the detecting regions before administrating with 99mTc-3PRGD2 at a mean radioactivity of 849±115 MBq via single intravenous bolus injection 2 h prior to SPECT/CT imaging. Tumor samples for detecting αvβ3 were collected by surgical operations two weeks after the scintigraphy. The results of CT and SPECT scanning were merged and compared. The correlation between tumor occupation (T/N ratio) and αvβ3 expression level were analyzed. The T/N ratios in brain glioma were proportionally correlated to αvβ3 positive cell percentage (R2=0.9253, p<0.05). This study primarily evaluated the clinical application of 99mTc-3PRGD2 SPECT scintigraphy on brain glioma. The more pathological types and detecting strategies covering a large amount of samples would aid to clarify the potentials. © 2013, Science Press. All rights reserved.

Gao S.,Jilin University | Ji T.,Jilin University | Wen Q.,Jilin University | Chen B.,Jilin University | And 3 more authors.
Nuclear Science and Techniques | Year: 2013

In this paper, the safety and efficacy of 131I-labeled mouse/human chimeric monoclonal antibody (131I-chTNT)-mediated radioimmunotherapy are evaluated because the patients have non-uptaking 131I pulmonary metastases from differentiated thyroid carcinoma (DTC). The 16 patients were injected intravenously by 29.6±3.7 MBq·kg-1 using 131I-chTNT. The chest computer tomography was performed before treatment, as well as 28 and 70 days after treatment. Responses and safety were assessed during the treatment. The results show that the 131I-chTNT infusion was well tolerated with the 12.5% complete response, 18.8% partial response, 25.0% progressive disease, and the 43.8% stable disease, indicating that most treatment-related adverse effects are mild transient and reversible. The 131I-chTNT is promising for patients with non-uptaking the 131I pulmonary metastases from DTC. © 2013, Science Press. All rights reserved.

Huang S.,U.S. Center for Disease Control and Prevention | Zhou S.,Longhua New District Center for Disease Control and Prevention | Zhang Y.,U.S. Center for Disease Control and Prevention | Lv Z.,U.S. Center for Disease Control and Prevention | And 11 more authors.
PLoS ONE | Year: 2015

microRNA (miRNA) plays a role in the pathogenesis of ischemic stroke, and single nucleotide polymorphisms in miRNA genes may contribute to disease susceptibility. However, the effect of miR-146a, miR-196a2, and miR-499 polymorphisms on ischemic stroke susceptibility has been rarely reported. Using the TaqMan assay, we evaluated the association of hsa-miR-146a/rs2910164, hsa-miR-196a2/rs11614913, and hsa-miR-499/rs3746444 polymorphisms with the risk of ischemic stroke in a Chinese population with 531 ischemic stroke patients and 531 control subjects. Rs2910164 C/G genotypes were significantly associated with increased risk of ischemic stroke in different genetic model (homozygote comparison: OR = 2.00, 95% CI, 1.29-3.12, P = 0.002; additive model: OR = 1.35, 95% CI, 1.10-1.65, P = 0.004;dominant model: OR = 1.33, 95% CI, 1.00-1.75, P = 0.049; recessive model: OR = 1.82, 95%CI, 1.20-2.74, P = 0.004). Subjects with allele G of hsa-miR-146a/ rs2910164 also showed increased risk of ischemic stroke (OR = 1.33, 95%CI, 1.09-1.62, P = 0.005). Stratification analysis showed that the association between rs2910164 and the risk of ischemic stroke was more pronounced in subjects over 60 years old, females, non-drinkers, subjects without hypertension or diabetesmellitus. There were significant combined effects between miR-146a/rs2910164 and fasting glucose/low-density lipoprotein cholesterol levels on ischemic stroke susceptibility. However, we failed to find any association between the alleles/genotypes of rs11614913 T/C and ischemic stroke, respectively (P> 0.05). In summary, this study provides evidence that miR-146a/rs2910164 might be associated with a significantly increased risk of ischemic stroke in a Chinese population, and the combined effects between miRNA polymorphism and fasting glucose /blood lipid levels may contribute to stroke pathogenesis. © 2015 Huang et al.

Shao Y.,Peoples Hospital of Shenzhen Longgang District | Wu B.,Peoples Hospital of Shenzhen | Li J.,Peoples Hospital of Shenzhen
Medical Journal of Wuhan University | Year: 2010

Objective: To investigate the changes of serum nervous system specific proteins in neonates of different gestational age (GA) without brain lesion, and to evaluate the clinical value of these indexes in predicting the mental maturity of neonates. Methods: Eighty-four newborns of different GA older than 7 days without brain lesion were assigned into four groups (I, II, III, and IV) according to GA of 28-31, 32-34, 35-36, and ≥37 weeks respectively. Serum neuron-specific enolase (NSE), S100 protein (S100), and myelin basic protein (MBP) were determined at the age of 2-3 days after birth by enzyme linked immunosorbent assay in all subjects. Serum NSE, S100, and MBP were re-determined in 27 of all subjects older than 7 days. Results: Serum MBP, NSE, and S100 among I, II, III, and IV groups had no significant difference (all P>0.05). Serum NSE and S100 levels increased at the age of 2-3 days as compared with those > 7-day old in the newborns without brain lesion respectively (P=0.018, 0.016 respectively), however, serum MBP between 2- or 3-day age and > 7 day age group showed no significant difference (P>0.05). There was a weak negative relation between serum S100 and GA(r=-0.270, P=0.013). No significant relation between GA and the serum levels of MBP or NSE. Conclusion: Serum S100 is related to neonatal maturity but serum MBP and NSE are not associated with neonatal maturity. Serum NSE and S100 levels change along with neonate's age after birth, but serum MBP is relatively stable in the neonatal stage.

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