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Wang B.,Tianjin Medical University | Zhang C.,Peoples Hospital of Rizhao City | Zhang S.,Tianjin Medical University | Yue K.,Tianjin Medical University | Wang X.,Tianjin Medical University
Chinese Journal of Clinical Oncology | Year: 2012

Objective: This study was performed to investigate the role of epithelial-mesenchymal transformation (EMT) in the lymph node metastasis of oral squamous cell carcinoma (OSCC) and its regulatory mechanism. Methods: The expression of the Chemokine C-X-C motif receptor 4 (CXCR4) and EMT-related factors in 60 cases with OSCC was analyzed via immunohistochemical assay. The χ2 or Fisher's exact probability test was used to analyze the relationship between the expression of EMT-related factors and clinico-pathologic data of the OSCC patients. Spearman correlation analysis was used to analyze the correlation between CXCR4 and EMT-related factors. Results: The results of the χ2 or Fisher's exact probability test showed that the expression of CXCR4, β-catenin, E-cadherin, N-cadherin, Twist, and Snail in the groups with and without lymph-node metastasis were statistically significant (P<0.05). Moreover, a statistical correlation exists between CXCR4 and the degree of differentiation. A correlation was also found among β-catenin, the degree of differentiation, and T staging. Moreover, a similar relationship was found among E-cadherin, tumor site, and the degree of differentiation, as well as between Twist and the degree of differentiation (P<0.05). The Spearman analysis showed that the expression of CXCR4 has a negative correlation between the expression of CXCR4 and β-catenin. The correlation coefficient was -0.497. However, a positive correlation among the expression of CXCR4 with Twist, Snail, and N-cadherin was observed, with correlation coefficients of 0.256, 0.300, and 0.333, respectively (P<0.05). Conclusion: EMT has an important function in the lymph node metastasis of OSCC. The CXCL12/CXCR4 biological axis may act on a particular EMT function and regulate the occurrence of EMT. Source

Liu D.-T.,Jining Medical University | Peng-Zhao,Jining Medical University | Han J.-Y.,Peoples Hospital of Rizhao City | Lin F.-Z.,Jining Medical University | And 2 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2014

Recently, the transcription factor SOX11 has gained extensive attention as a diagnostic marker in a series of cancers. However, to date, the possible roles of SOX11 in breast cancer has not been investigated. In this study, immunohistochemical staining for SOX11 was performed for 116 cases of breast cancer. Nuclear SOX11 was observed in 42 (36.2%) and cytoplasmic SOX11 in 52 (44.8%) of breast cancer samples. Moreover, high expression of cytoplasmic and nuclear SOX11 was associated with clinicopathological factors, including earlier tumor grade, absence of lymph node metastasis and smaller tumor size. Kaplan-Meier survival curves demonstrated high nuclear SOX11 expression to be associated with more prolonged overall survival than those with low expression and it could be an independent predictor of survival for breast cancer patients. It is worthwhile to note that cytoplasmic SOX11 was not correlated with prognosis of breast cancer patients. These data suggest the possibility that nuclear SOX11 could be as a potential target for breast cancer therapy. Source

Liu J.-Q.,Peoples Hospital of Rizhao City | Leng J.,Peoples Hospital of Rizhao City | Sang L.,Peoples Hospital of Rizhao City | Li T.-Y.,Peoples Hospital of Rizhao City
Journal of Leukemia and Lymphoma | Year: 2010

Objective: To explore the efficacy and side effect of inductive chemotherapy with low-dose, cytarabine, homoharringtonine and granulocyte colony-stimulating factor(CHG) in elderly acute myeloid leukemia(AML). Methods: Thirty-five elderly patients (age>60 years) with AML were enrolled for the initial treatment with CHG regimen, The CHG regimen consisted of cytarabine 10 mg/m2 per 12 h by subcutaneous injection, days 1-14, homoharringtonine 1 mg/m2 per day by intravenous continuous infusion, days 1-14, and G-CSF 200 μg/m2 per day by subcutaneous injection 12 h before chemotherapy, days 0-14. G-CSF only was used when white blood cell count(WBC) was less than 20x109/L during the whole course. Results: After the first course, 12 patients achieved complete response (CR), 15 patients achieved partial response (PR), and 8, patients had no response(NR). After the second course, 5 of 15 PR patients achieved CR, 2 of 8 NR patients achieved PR. The total effective rate was 82 % (29/35). Of those 17 CR patients, eleven patients continued maintenance therapy and remained in remission for 12-34 months with a median CR duration of 18 months, the other 6 patients relapsed and were treated with original regimen, including one achieved CR again, 4 achieved PR, and 1 achieved NR. The CHG regimen had mild hematologic toxicities and no severe nonhematologic toxicities. Conclusion: CHG regimen is effective and well tolerated in remission for elderly AML. Source

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