Huang H.-D.,Shanghai University |
Li Q.,Shanghai University |
Huang Y.,Shanghai University |
Bai C.,Shanghai University |
And 4 more authors.
Chinese Medical Journal | Year: 2012
Background In our clinical practice we have been attracted by a group of patients with airway aspergillosis who have airway obstruction; we termed the condition as pseudomembranous necrotizing tracheobronchial aspergillosis (PNTA). In this study we analyzed the clinical data from patients with PNTA, so as to guide the diagnosis and treatment of the disease. Methods A total of 16 PNTA patients were treated in Changhai Hospital from January 2000 to January 2009. Their clinical data, including the demographic information, clinical symptoms, imaging findings, bronchoscopy findings, treatment strategies and efficacy, and prognosis, were retrospectively analyzed. Results All 16 patients were found to have primary systemic immunodeficiency diseases and/or damage of the focal airways. Nine patients (9/16, 56.3%) had pulmonary and tracheobronchial tumors, 5/16 (31.3%) had tracheobronchial involvement secondary to non-pulmonary tumors, and 2/16 (12.5%) had lung transplantation. The most common causes of PNTA included local radiotherapy (10/16, 62.5%), repeated chemotherapy (7/16, 43.8%) and recurrent intervention therapy by bronchoscope (4/16, 25.0%). Aspergillus fumigatus was the most frequent pathogen (62.5%, 10/16). The main clinical manifestations included progressive dyspnea (14/16, 87.5%) and irritable cough (12/16, 75.0%). The trachea was involved in 9/16 patients (56.3%), right main bronchus in 10/16 (62.5%). All 16 patients were treated with systemic anti-aspergillosis agents, local anti-aspergillosis agents with amphotericin B inhalation and direct perfusion of amphotericin B by bronchoscope, and interventional treatment by bronchoscope to ensure an unobstructed airway. The total efficiency was 31.3%. Conclusions PNTA is an infectious disease caused by aspergillus and it mainly involves the trachea, primary bronchus and segmental bronchus. A. fumigatus is the most common pathogen. PNTA can pose a severe clinical threat and often occurs after systemic immunodeficiency and/or local airway damage, with the main symptoms including dyspnea and irritable cough. Bronchoscopic findings supply the main evidence for diagnosis of PNTA. Treatment of PNTA is difficult and requires a long course. Systemic and local anti-aspergillosis agents plus bronchoscopy debridement can improve the prognosis of the disease.
Li Y.-H.,Peoples Hospital of Pudong New Area |
Li Y.-H.,Shanghai JiaoTong University |
Sun W.-J.,Peoples Hospital of Pudong New Area |
Zhao Z.-G.,Peoples Hospital of Pudong New Area |
And 2 more authors.
Academic Journal of Second Military Medical University | Year: 2010
Objective: To analyze the correlation of intervetebral disc degeneration with the diffusion values of lumbar vertebral discs and lumbar blood supply in patients with suspected lumbar intervertebral problems, so as to assess ADC value in diagnosis of intervertebral degeneration and the related blood supply. Methods: Sixty-five patients with suspected lumbar intervertebral problems were included in the present study; they had a mean age of (52.3±28.5) years and an age range of 16-76 years. Eleven of them had low back pain complicated with sciatica, 16 had low back pain without sciatica, 33 had sciatica without low back pain, and 5 had intermittent claudication. The disease course was 1-57 weeks, with a mean of (13.4±6.3) weeks. MR angiography and diffusion imaging were performed to evaluate the status of lumbar arteries and to obtain the ADC values of L1-4, so as to analyze the correlation of ADC values, lumbar blood supply, and intervetebral disc degeneration. Results: The ADC values of L1-4 were negatively correlated with the degeneration of lumbar discs (P<0.05). There was a relation between the artery status of L1, L2 and L3 with the degeneration of corresponding lumbar discs of L1-2, L2-3, and L 3-4, (r3 = 0.823, P = 0.016 3 ; r5 = 0.791, P = 0.019 2; r, = 0.835, P = 0.010 3). The artery status of L4 and the L4-5 discs was not significantly correlated with degeneration of corresponding lumbar discs(r3 =0.306, P = 0.209 2). Conclusion: The ADC values of lumbar intervertebral disc can reflect the degeneration of L 1-4 , and degeneration of L1-2, L2-3 is and L3-4 is correlated with the artery status of corresponding discs.
Sun N.,Gongli Hospital |
Xu W.-H.,Gongli Hospital |
Cao L.-H.,Ningxia Medical University |
Zhao X.-Y.,Ningxia Medical University |
And 4 more authors.
Experimental and Therapeutic Medicine | Year: 2013
Ossifying fibroma is a rare benign tumor of the nasal cavity and the paranasal sinus, and is easily misdiagnosed. In the present study, we report the clinical data in the case of a 46-year-old female patient, treated due to 5-day forehead swelling accompanied by dizziness. CT examination revealed dilation of the right frontal sinus, bone wall integration, dense masses in the cavity, multiple punctate calcification foci internally and no nasal obstruction, nasal mucus or epistaxis. After hospitalization, a right frontal sinus fenestration and tumor resection plus nasofrontal duct reconstruction combined with nasal endoscopic frontal recess open surgery was conducted under general anesthesia. Following the tumor resection, the frontal sinus bone lamella was reset and fixed with a titanium bone fixation set. The postoperative pathological diagnosis was of ossifying fibroma. At the postoperative 5-year follow-up there was no tumor recurrence and nasal endoscopy revealed an unobstructed nasofrontal duct opening.
Zhang Q.,Second Military Medical University |
Zhang Q.,Shanghai Ocean University |
Wang C.,Second Military Medical University |
Liu Z.,Peoples Hospital of Pudong New Area |
And 4 more authors.
Journal of Biological Chemistry | Year: 2012
Multiple signaling pathways are involved in the tight regulation of Toll-like receptor (TLR) signaling, which is important for the tailoring of inflammatory response to pathogens in macrophages. It is widely accepted that TLR signaling can activate Notch pathway; however, whether full activation of Notch signaling can feedback modulate TLR signaling pathway so as to control inflammation response remains unclear. Here, we demonstrated that stimulation with TLR ligands up-regulated Notch1 and Notch2 expression in macrophages. The expression of Notch target genes including Hes1 and Hes5 was also induced in macrophages by LPS, suggesting that TLR4 signaling enhances the activation of Notch pathway. Importantly, overexpression of constituted active form of Notch1 (NICD1) and Notch2 (NICD2) suppressed production of TLR4-triggered proinflammatory cytokines such as TNF-α and IL-6 but promoted production of antiinflammatory cytokine IL-10, which is dependent on the PEST domain of NICD. In addition, NICD1 and NICD2 suppressed TLR-triggered ERK phosphorylation, which is indispensable for Notch-mediated inhibition of TLR4- triggered proinflammatory cytokine production. Furthermore, activation of Notch signaling inhibited NF-κB transcription activity by MyD88/TRAF6 and TRIF pathways, which was dependent on ERK activity. Therefore, our results showed that Notch signaling negatively regulates TLR-triggered inflammation responses, revealing a new mechanism for negative regulation of TLR signaling via Notch pathway. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.
Wang W.,Peoples Hospital of Pudong New Area |
Li Z.-X.,Peoples Hospital of Pudong New Area |
Chen Y.-Y.,Peoples Hospital of Pudong New Area |
Yin Z.-G.,Peoples Hospital of Pudong New Area
Ophthalmology in China | Year: 2010
Objective To investigate indications of occlusion in the treatment of children's amblyopia. Design Prospective cohort study. Participants 147 eyes of 90 children with amblyopia. Methods The study involved 90 children aged 3 to 10 years. The Ieteral difference of best corrected visual acuity (BCVA) was more than 1 line (measured by the international standard visual acuity chart). Among them, 56 children (112 eyes) with ametropic amblyopia and normal stereopsis were randomly divided into 2 groups, Group A and Group B, 28 children in each group. 34 children(35 eyes) with abnormal binocular vision were randomly divided into 2 groups, Group C and Group D, 17 children in each group. Children in Group A and Group C were given routine therapy and the occlusion therapy. Children in Group B and Group D were given routine therapy only. All patients were followed up at 2 months, 4 months and 6 months after therapy. Main Outcome Measures The BCVA change after the treatment. Results The BCVA of all children was improved. There was no significant difference statistically between the improvement of Group A and Group B (P>0.05). But the improvement of BCVA in Group C was significantly better than that in Group D. Conclusion The occlusion therapy is beneficial to the children with amplyopia and abnormal binocular vision, but not the indication for the amplyopic children with normal binocular vision.
Yang Z.,Peoples Hospital of Pudong New Area |
Sheng C.,Peoples Hospital of Pudong New Area
Chinese Journal of Clinical Oncology | Year: 2012
Genome-wide association studies have revealed a correlation between the hereditary change in the chromosome 8q24 zone and the risk of prostate cancer (PCa). The various single nucleotide polymorphisms are of considerable interest, particularly the rs1447295A/C polymorphism, which has been studied in different populations, including Europeans, Africans, Asians, and their descendants. Large-scale studies have confirmed the remarkably strong association of the rs1447295A/C polymorphism with the risk of PCa. Recent advances in the relationship between the rs1447295A/C polymorphism in chromosome 8q24 and the risk of PCa were reviewed in this paper.
Yang Z.,Peoples Hospital of Pudong New Area |
Sheng C.,Peoples Hospital of Pudong New Area |
Cao L.,Peoples Hospital of Pudong New Area |
Wang D.,Peoples Hospital of Pudong New Area
Journal of the Canadian Urological Association | Year: 2013
The rete testis consists of a series of interconnected wide channels lined with a simple cuboidal to columnar epithelium. We report such a rare tumour in a 57-year-old male with widespread metastasis. © 2013 Canadian Urological Association.
PubMed | Peoples Hospital of Pudong New Area and Pudong New Area Hospital of Traditional Chinese Medicine
Type: | Journal: Medical science monitor : international medical journal of experimental and clinical research | Year: 2016
BACKGROUND The aim of this study was to investigate the potential value of apparent diffusion coefficient (ADC) of diffusion-weighted imaging (DWI) in the prognosis of patients with hyperacute cerebral infarction (HCI) receiving intravenous thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA). MATERIAL AND METHODS From June 2012 to June 2015, 58 cases of HCI (<6 h) undergoing rt-PA intravenous thrombolytic therapy (thrombolysis group) and 70 cases of HCI (<6 h) undergoing conventional antiplatelet and anticoagulant therapy (control group) in the same period were collected. DWI was conducted on all the subjects, and ADC maps were generated with Functool software to quantify ADC value. The clinical outcomes of HCI patients were observed for 3 months, and prognostic factors were analyzed. RESULTS Before thrombolysis treatment, the lesion area presented high signal intensity on DWI map and low signal intensity on ADC map, and gradually weakened signal intensity on DWI map and gradually enhanced signal intensity on ADC map were observed after thrombolysis. The ADC values of the thrombolysis group were significantly higher than those of the control group after treatment (24 h, 7 d, 30 d, and 90 d) (all P<0.05), and the ADC and rADC values in the thrombolysis group gradually increased over time (all P<0.05). Multiple logistic regression analysis showed that baseline National Institutes of Health Stroke Scale (NIHSS) score, baseline rADC value, and stroke history were the independent factors for the prognosis of HIC patients with thrombolysis (all P<0.05). CONCLUSIONS The values of ADC and rADC may provide guidance in the prognosis of HCI patients receiving rt-PA, and the baseline rADC value is the protective factor for the prognosis of HCI patients receiving rt-PA.