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Fan W.,Peoples Hospital of Jiangsu Province | Zhang Q.,Traditional Chinese Medical Hospital of Changshu City | Jiang T.,Peoples Hospital of Jiangsu Province
Sexually Transmitted Infections | Year: 2014

Objective: To investigate the pathogen profile in men with inflammation of the paraurethral glands. Methods: We enrolled 40 patients with first-onset, drug-naive inflammation of the paraurethral glands. Discharge from the lesions was collected for Gram staining. Microscopy was performed for screening for trichomonads and detecting Gram-negative intracellular diplococci within phagocytes. Cultures for detection of Neisseria gonorrhoeae, Ureaplasma urealyticum and other bacteria, and Chlamydia-trachomatis-associated antigens were performed. PCR was conducted for herpes simplex virus type 1 or 2. Results: From these 40 patients, there were nine microbial species, which included Gram-negative bacteria (23 cases, 54.8%), Gram-positive bacteria (15 cases, 35.7%) and other pathogens (4 cases, 9.5%). The top three pathogens were gonococci (38.1%), Staphylococcus aureus (16.7%) and Escherichia coli (14.3%). Conclusions: Inflammation of paraurethral glands in men may be caused by a variety of pathogens and not just by gonococcal infection.

Yang L.,Zunyi Medical College | Yang L.,Peoples Hospital of Jiangsu Province | Yu T.,Zunyi Medical College
Journal of Thoracic and Cardiovascular Surgery | Year: 2010

Objective: Prolonged donor heart preservation is important in cardiovascular surgery. This study examined the effect of pinacidil, a nonselective adenosine triphosphate-sensitive potassium channel opener, on donor heart preservation when added to histidine tryptophan ketoglutarate solution and the role of mitochondria in this protection. Methods: Sprague-Dawley rat hearts received one of 5 preservation solutions in the Langendorff perfusion apparatus (24 per group): (1) histidine tryptophan ketoglutarate solution; (2) histidine tryptophan ketoglutarate solution containing pinacidil; (3) histidine tryptophan ketoglutarate solution containing pinacidil and 5-hydroxydecanote, a mitochondrial adenosine triphosphate-sensitive potassium channel blocker; (4) histidine tryptophan ketoglutarate solution containing pinacidil and Hoechst-Marion-Roussel 1098, a sarcolemmal adenosine triphosphate-sensitive potassium channel blocker; and (5) histidine tryptophan ketoglutarate solution containing pinacidil, 5-hydroxydecanote, and Hoechst-Marion-Roussel 1098. After a 10-minute equilibration period, all the hearts in the different preservation solutions were placed in cold storage for 8 hours, followed by 60 minutes of reperfusion. Hemodynamics, mitochondrial respiratory function, adenosine triphosphate level, cardiac troponin I release, and ultrastructure were examined. Results: Histidine tryptophan ketoglutarate solution containing 0.5 mmol/L pinicidal significantly improved heart function, coronary flow, myocardial ultrastructure, and cardiac troponin I release after reperfusion (P < .01 or P < .05). In the pinacidil group at the end of storage and the end of reperfusion, mitochondrial respiratory function and myocardial adenosine triphosphate levels were superior when compared with other groups (P < .01 or P < .05). These beneficial effects of pinacidil were blocked by 100 μmol/L 5-hydroxydecanote. Conclusion: Histidine tryptophan ketoglutarate solution containing pinacidil provides better cardioprotection with preservation of mitochondrial energy. This effect of pinacidil appears to depend on both mitochondrial and sarcolemmal adenosine triphosphate sensitive potassium channel. © 2010 The American Association for Thoracic Surgery.

Ma C.-C.,Peoples Hospital of Jiangsu Province | Wu S.-W.,Peoples Hospital of Jiangsu Province
Hepato-Gastroenterology | Year: 2013

Background/Aims: Anastomotic leakage is a complication of low anterior resection (LAR) for rectal cancer with total mesorectal excision (TME). This study evaluated the need for a protective stoma by a three-year follow-up. Methodology: A retrospective study of 56 LAR patients was conducted. Thirty patients (53.6%) had a protective stoma. C-reactive protein (CRP), interleukin 6 (IL-6) and tumor necrosis factor (TNF) in peripheral blood on the first and third day after surgery were compared, in addition to short-term and later complications, long-term mortality and quality of life (QOL). Results: There was significant difference between patients with and without a stoma in CRP, IL-6 on the third day after surgery (p<0.05). Anastomotic leakage occurred in two patients (6.7%) with a stoma and seven (26.9%) without (p=0.039). The incidence of leaks requiring re-operation was significantly lower with a stoma (p=0.012). After a mean follow-up of three years, there was no difference in long-term mortality, survival or scores on QOL questionnaires. Conclusions: A protective stoma can reduce the stress reaction, promote recovery of bowel function and reduce anastomotic leakage and re-operation rates in LAR for rectal cancer with TME. No significant difference was observed in long-term mortality or QOL. © H.G.E. Update Medical Publishing S.A.

Xie M.,Peoples Hospital of Jiangsu Province
Iranian Journal of Radiology | Year: 2011

Background: Lung masses are often difficult to differentiate when their clinical symptoms and shapes or densities on computed tomography (CT) images are similar. However, with different pathological contents, they may appear differently on plain and enhanced CT. Objectives: To determine the value of enhanced CT for the differential diagnosis of lung masses based on the differences in radiodensity with and without enhancement. Patients and Methods: Thirty-six patients with lung cancer, 36 with pulmonary tuberculosis (TB) and 10 with inflammatory lung pseudotumors diagnosed by CT and confirmed by pathology in our hospital were selected. The mean ± SD radiodensities of lung masses in the three groups of patients were calculated based on the results of plain and enhanced CT. Results: There were no significant differences in the radiodensities of the masses detected by plain CT among patients with inflammatory lung pseudotumors, TB and lung cancer (P > 0.05). However, there were significant differences (P < 0.01) between all the groups in terms of radiodensities of masses detected by enhanced CT. Conclusions: The radiodensities of lung masses detected by enhanced CT could potentially be used to differentiate between lung cancer, pulmonary TB and inflammatory lung pseudotumors. © 2011, Tehran University of Medical Sciences and Iranian Society of Radiology. Published by Kowsar M.P.Co. All rights reserved.

Zong L.,Peoples Hospital of Jiangsu Province | Chen P.,Peoples Hospital of Jiangsu Province | Xu Y.,Peoples Hospital of Jiangsu Province
European Journal of Surgical Oncology | Year: 2012

Purpose: The published data about p53 expression and its potential value in malignant risk of Gastrointestinal Stromal Tumors patients seemed inconclusive. To derive a more precise estimation of the relationship between p53 and Malignant risk of GIST, a meta-analysis was performed. Materials and methods: Studies have been identified by searching PubMed and Embase. Inclusive criteria were GIST patients, evaluation of p53 expression and malignant risk. The odds ratio (OR) for positive rate of p53 in NIH very low risk group vs. NIH low risk group, the odds ratio (OR) for positive rate of p53 in NIH low risk group vs. NIH Intermediate risk group and the odds ratio (OR) for positive rate of p53 in NIH Intermediate group vs. NIH high risk group were calculated with 95% confidence interval (CI) for each study as an estimation of potential value of p53 in malignant risk of GIST. Results: A total of 9 studies including 768 patients were involved in this meta-analysis. The meta-analysis of positive rate of p53 in NIH VL group vs. NIH L group did not attain significant difference (OR 0.38 95% CI, 0.11-1.28; P = 0.12 P heterogeneity = 0.51). However the overall OR for positive rate of p53 in NIH L group vs. NIH I group revealed that significantly elevated risks of positive p53 in NIH I group were achieved (OR 0.44 95% CI, 0.24-0.82; P = 0.009 P heterogeneity = 0.32). The overall OR for NIH I group vs. NIH H group was 0.62 (95% CI, 0.37-1.02; P = 0.06 P heterogeneity = 0.25). Conclusion: The results indicate p53 overexpression correlate with the malignant risk increasing of GIST and have a primary and closest relationship within the NIH I risk group of GIST. © 2011 Elsevier Ltd. All rights reserved.

Yang Z.,Peoples Hospital of Jiangsu Province
Current Medical Research and Opinion | Year: 2015

Objective: To investigate the efficacy and safety of perindopril-lercanidipine combination versus perindopril or lercanidipine monotherapies in patients with mild essential hypertension.Methods: A total of 180 patients with mild essential hypertension were randomly assigned to three groups: group A (perindopril 2 mg plus lercanidipine 5 mg; n = 60), group B (lercanidipine 10 mg; n = 60) and group C (perindopril 4 mg; n = 60). The treatment efficacy and the incidence of adverse events were evaluated at the end of 4, 8 and 12 weeks after treatment initiation.Results: The blood pressure in group A was already lower than in group B and group C at week 4 after treatment initiation. Systolic blood pressure was 148 ± 13 mmHg in group A, 151 ± 14 mmHg in group B, and 153 ± 13 in group C (p < 0.001); diastolic blood pressure was 89 ± 8, 92 ± 7 and 92 ± 6 mmHg, respectively (p < 0.001). At the end of treatment the normalization rate was significantly higher in group A, compared with group B and group C (71.7%, 68.3%, and 48.3%, respectively; p < 0.05). Four adverse events were observed in group A, while seven and nineteen adverse events occurred in group B and in group C, respectively. Statistically significant differences in adverse reaction incidence were reported among three groups.Conclusion: Although its results were collected in an overall limited number of patients in a single center, this study shows that the combination of perindopril and lercanidipine, compared with lercanidipine alone or perindopril alone, was effective in improving blood pressure in mild essential hypertensive patients, and also decreased the incidence of adverse events. © 2015 Informa UK Ltd.

Yuan K.,Soochow University of China | Yuan K.,Peoples Hospital of Jiangsu Province | Chen H.-L.,Nantong University
International Journal of Surgery | Year: 2013

Objectives: The aim of this meta-analysis is to assess the association between obesity and risk of surgical site infections (SSI) risk in orthopedics. Methods: We searched the electronic database of PubMed and Web of Science for observational studies about risk factors for SSI risk in orthopedics, meta-analysis of body mass index (BMI) between infection group and no infection group, infection rate in obesity expose and no obesity expose were conducted, respectively. Results: A total of 20 studies included in the meta-analysis. The pooled weighted mean difference (WMD) of BMI between infection group and no infection group was 0.329 (95% CI 0.215-0.444), which was statistically significant (. z = 5.65, p = 0.000). The pooled relative risk (RR) of infection rate compare obesity expose with no obesity expose was 1.915 (95% CI 1.530-2.396), which was statistically significant (. z = 5.68, p = 0.000). No publication bias was found (Begg test P = 0.174 and Egger test P = 0.345) in pooled WMD of BMI. But there was significant publication bias in pooled RR of infection rate (Begg test P = 0.001 and Egger test P = 0.001). Conclusion: Our meta-analysis indicates that obesity had about twofold increased risk of surgical site infections risk in orthopedics. However, this conclusion should be verified by further well designed prospective cohort studies. © 2013 Surgical Associates Ltd.

Chen Y.L.,Peoples Hospital of Jiangsu Province
Zhongguo zhen jiu = Chinese acupuncture & moxibustion | Year: 2012

To evaluate the therapeutic effect of Parkinson's disease combined with overactive bladder syndrome (GAB) treated with combined therapy of oral administration of Tolterodine with low dose and electroacuponcture. Sixty cases of Parkinson's disease combined with GAB were randomly divided into a combined acupuncture and medication group (group A) and a medication group (group B), 30 cases in each group. In both groups, Madopar basic doses were same, and anticholinergic agents such as Artane were stopped. In group A, Tolterodine was orally taken for 1 mg, twice a day; Baihui (GV 20), Sishengcong (EX-HN 1) and Yintang (EX-HN 3) were punctured with electroacupuncture, once a day. In group B, Tolterodine was orally taken for 2 mg, twice a day. After 6 weeks, the changes of urination and UPDRS III scores were observed, and the adverse reactions were recorded in both groups. After treatment, the frequency of average urination of 24 hours, frequency of incontinence of 24 hours and average urine volume at a time were obviously improved (all P < 0. 01), of which, the above items in group A were superior to those in group B (all P < 0. 05) the UPDRSIII score in group A was superior to that in group B (P < 0.05). The adverse reactions in group A were less than those in group B. The therapeutic effect of Parkinson' s disease combined with GAB treated with combined therapy of Tolterodine with low dose and electroacupuncture is superior to that of complete dose of Tolterodine with oral administration, with less adverse reactions. And it also can improve the motor symptom of Parkinson's disease patients.

Zhu W.,Peoples Hospital of Jiangsu Province | Zhang Z.,Yangzhou University
International Journal of Biological Macromolecules | Year: 2014

In the present study, the preparation, characterization, antioxidant and antidiabetic activities of catechin-grafted chitosan (catechin-g-chitosan) were investigated. The graft of catechin onto chitosan was achieved by redox system and confirmed using various instrumental methods. Proton nuclear magnetic resonance spectroscopy indicates that catechin has been successfully grafted onto chitosan. The morphology observation shows that chitosan changes to a softened nature with porous surface after grafting. Catechin-g-chitosan also exhibits reduced thermal stability and enhanced crystallinity compared to chitosan. Moreover, catechin-g-chitosan shows 0.51 of reducing power, 46.81% of hydroxyl radical-scavenging activity and 67.08% of DPPH radical-scavenging activity at 1. mg/ml, which are much higher than that of chitosan. The antidiabetic activity in vitro assays shows that the α-glucosidase inhibitory effect decreases in the order of catechin-g-chitosan. >. catechin. >. acarbose. >. chitosan, and the α-amylase inhibitory effect decreases in the order of acarbose. >. catechin-g-chitosan. >. catechin. >. chitosan. The improved antioxidant and antidiabetic activities of catechin-g-chitosan are attributed to the phenolic groups in the catechin residues. © 2014 Elsevier B.V.

Xian J.C.,Peoples Hospital of Jiangsu Province
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology | Year: 2011

To investigate the relevant factors of liver histological changes in chronic hepatitis B (CHB) patients with mildly elevated ALT and to explore the clinical values of these factors on anti-viral treatment. A total of 152 CHB patients with mildly elevated ALT (less than 2 x ULN) who underwent liver biopsy were included in the study. Correlations between routine laboratory markers, liver histological inflammation grade and fibrosis stage were statistically assessed by Spearman correlation analysis, one-way ANOVA, area under the curve (AUC) of the receiver operating characteristic curves (ROC) and Logistic regression statistical analysis. All patients in the study showed various hepatic histological damages. Among the 152 patients 50 (32.9%) were found with inflammation grade 1 (G1), 42 (27.6%) with G2, 46 (30.3%) with G3 and 14 (9.2%) with G4. 16 patients (10.5%) were found with fibrosis stage 2 (S2), 25 (16.5%) with S3 and 41 (27.0%) with S4. Routine laboratory markers Alb, BPC and WBC were significantly correlated with hepatic histological inflammation grade and fibrosis stage. Marked liver fibrosis and moderate to severe liver damage were significantly higher in patients aged more than 40 years as compared to those less than 40 years of age (P = 0.002, P = 0.010). The regression equation P = 1/[1+e-(9.36250-1625Alb-0.0234BPC)] was established with sensitivity and specificity of 83.3% and 65.0%, respectively. 67.8% of CHB patients with mildly elevated ALT have significant injury to the liver tissue. CHB patients aged more than 40 years have a significant increase of marked liver fibrosis and moderate to severe liver damage. The regression equation is valuable to predict whether CHB patients need antiviral therapy or not.

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