Peoples Hospital of Jiangbei

Nanjing, China

Peoples Hospital of Jiangbei

Nanjing, China
SEARCH FILTERS
Time filter
Source Type

Luan L.,Peoples Hospital Of Jiangbei | Li R.,The Third Peoples Hospital Of Anyang | Wang Z.,Maternal and Child Health Care Hospital of Weifang | Hou X.,Weifang Medical University | And 4 more authors.
Osteoporosis International | Year: 2016

Many studies have investigated the association between stroke and hip fracture risk, but the precise association was still unclear due to insufficient statistical power in single studies with relatively small sample size. Thus, we firstly conducted a meta-analysis of all published studies to precisely estimate the relationship of stroke with hip fracture risk. The strength for this relationship was weighed by pooled relative risks (RRs) with 95 % confidence intervals (95 % CIs) after adjustment for confounding variables. Stratified analyses by study design and ethnicity and sensitivity analysis were also performed. Two investigators independently performed a comprehensive literature search in databases of PubMed, Embase, and Wanfang for eligible articles. A Bayesian meta-analysis was also performed to get a more precise assessment of the relationship. Eleven relevant studies from 10 publications were finally included into our meta-analysis according to the inclusion criteria. Overall, stroke significantly and independently increased the risk of hip fracture (RR = 2.06, 95 % CI 1.68–2.52, P < 0.001). Bayesian meta-analysis showed that stroke was also associated with an over two-fold increased risk of hip fracture (RR = 2.11, 95 % CI 1.62–2.75). In stratified analysis, stroke could increase the risk of hip fracture in Caucasians (RR = 2.36, 95 % CI 1.83–3.05, P < 0.001). These data support the notion that stroke is an independent risk factor for hip fracture, and patients with stroke have a two-fold increased risk of hip fracture than those without stroke. © 2016 International Osteoporosis Foundation and National Osteoporosis Foundation


He X.,Peoples Hospital of Ganzhou | Wang P.,Maternal and Child Health Hospital of Weifang | Wang Z.,Maternal and Child Health Hospital of Weifang | He X.,Maternal and Child Health Hospital of Weifang | And 2 more authors.
European Journal of Endocrinology | Year: 2012

Background: Observational studies suggest possible associations between thyroid antibodies and risk of preterm delivery. However, whether thyroid antibodies are risk factors of preterm labor remains controversial. Our goal was to evaluate the associations between thyroid antibodies and risk of preterm delivery by conducting a meta-analysis of prospective cohort studies. Methods: PubMed, Embase, and Wangfang databases were searched through January 2012 to identify studies that met pre-stated inclusion criteria. Data were extracted using standardized forms. Either a fixed- or a random-effects model was used to calculate the overall combined relative ratio (RR) with its corresponding 95% confidence interval (95% CI) to evaluate the relationship between thyroid antibodies and preterm delivery risk. Subgroup analyses were mainly performed by type of thyroid antibodies including thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibody (TG-Ab). Results: Eleven prospective cohort studies involving 35 467 participants were included. The combined RR of preterm delivery for pregnant women with thyroid antibodies compared with the reference group was 1.41 (95% CI 1.08-1.84, P=0.011). Subgroup analysis yielded the combined RR of preterm delivery for pregnant women with TPO-Ab compared with the reference group was 1.69 (95% CI 1.19-2.41, P=0.003), whereas pregnant women with positive TG-Ab had no obvious risk of preterm delivery compared with the reference group (RR=0.88, 95% CI 0.60-1.29, P=0.513). Sensitivity analysis restricted to studies excluding women with thyroid dysfunction yielded similar results. Meta-regression analysis suggested that the status of exclusion or inclusion of women with thyroid dysfunction was the major source of heterogeneity in this meta-analysis. No evidence of publication bias was observed. Conclusions: Current evidence suggests that the presence of TPO-Ab in pregnant women significantly increases the risk of preterm delivery. © 2012 European Society of Endocrinology.


PubMed | Maternal and Child Health Care Hospital of Weifang, Weifang Medical University, Peoples hospital of Jiangbei and the Third Peoples Hospital of Anyang
Type: Review | Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA | Year: 2016

Many studies have investigated the association between stroke and hip fracture risk, but the precise association was still unclear due to insufficient statistical power in single studies with relatively small sample size. Thus, we firstly conducted a meta-analysis of all published studies to precisely estimate the relationship of stroke with hip fracture risk. The strength for this relationship was weighed by pooled relative risks (RRs) with 95% confidence intervals (95% CIs) after adjustment for confounding variables. Stratified analyses by study design and ethnicity and sensitivity analysis were also performed. Two investigators independently performed a comprehensive literature search in databases of PubMed, Embase, and Wanfang for eligible articles. A Bayesian meta-analysis was also performed to get a more precise assessment of the relationship. Eleven relevant studies from 10 publications were finally included into our meta-analysis according to the inclusion criteria. Overall, stroke significantly and independently increased the risk of hip fracture (RR=2.06, 95% CI 1.68-2.52, P<0.001). Bayesian meta-analysis showed that stroke was also associated with an over two-fold increased risk of hip fracture (RR=2.11, 95% CI 1.62-2.75). In stratified analysis, stroke could increase the risk of hip fracture in Caucasians (RR=2.36, 95% CI 1.83-3.05, P<0.001). These data support the notion that stroke is an independent risk factor for hip fracture, and patients with stroke have a two-fold increased risk of hip fracture than those without stroke.


Yan S.,Nanjing Medical University | Xu D.,Peoples Hospital of Jiangbei | Sun B.,Nanjing Medical University
Digestive Diseases and Sciences | Year: 2012

Background: Recent studies suggest that the combination of radiofrequency ablation (RFA) and transarterial chemoembolization (TACE) may have a synergistic effect for hepatocellular carcinoma (HCC). Aims: The aim of this meta-analysis was to compare the effectiveness of combination of RFA and TACE with that of RFA alone in patients with HCC. Methods: Randomized controlled trials and retrospective cohort studies comparing RFA plus TACE with RFA alone for HCC were included into this meta-analysis. Study quality was rated with a standardized scale and the strength of evidence was also rated by using the grading of recommendations assessment, development, and evaluation system (GRADE system). Results: Meta-analyses showed that the combination of RFA and TACE was obviously associated with higher survival rates (odds ratio [OR]1-year = 2.14, 95 % confidence interval [95 % CI] 1.57-2.91, P<0.001; OR3-year = 1.98, 95 % CI 1.28-3.07, P = 0.001; OR5-year = 2.70, 95 % CI 1.42-5.14, P = 0.003). The overall quality of evidence was judged to be low by using the GRADE system. Conclusions: The combination of TACE with RFA can improve the overall survival rate and provides better prognosis for patients with HCC, but more randomized controlled trials using large sample size are needed to provide sufficient evidence. © Springer Science+Business Media, LLC 2012.


Xu D.,Peoples Hospital of Jiangbei | Yan S.,Nanjing Medical University | Yin J.,Peoples Hospital of Jiangbei | Zhang P.,Peolples Hospital of Rizhao
Asian Pacific Journal of Cancer Prevention | Year: 2011

Background/Aims: Studies of associations between genetic polymorphism of glutathione S-transferase T1 (GSTT1) and risk of colorectal cancer (CRC) in Asian populations have reported controversial results. Thus, a meta-analysis was performed to clarify the effects of GSTT1 polymorphism on the risk of developing colorectal cancer. Methods: A literature search of PubMed and EMBASE up to June 7, 2011 was conducted and 13 eligible papers were finally selected, involving totals of 4,832 CRC cases and 7,045 controls. Subgroup analyses were performed according to the sample size and the research designwith the software programs Review Manager (version 5.0.10) and STATA (version 9.2). Results: Analyses of all relevant studies showed an increased CRC risk was significantly associated with the null genotypes of GSTT1 (OR=1.09, 95%CI=1.01-1.17, P OR=0.027; I 2=40.2%). Besides, a more obvious association was observed after heterogeneity was eliminated (OR=1.13, 95%CI 1.04-1.23, P OR=0.002; I 2=0.0%). Subgroup analyses and sensitivity analysis further identified an association in Asians. Conclusions: This meta-analysis demonstrated the GSTT1 null genotype to be associated with an increased risk of CRC in Asian populations.


Yan S.,Nanjing Medical University | Yan S.,Chinese People's Liberation Army | Xu D.,Peoples Hospital of Jiangbei | Sun B.,Nanjing Medical University
Digestive Diseases and Sciences | Year: 2013

Background: Recent studies suggest that the combination of radiofrequency ablation (RFA) and transarterial chemoembolization (TACE) may have a synergistic effect for hepatocellular carcinoma (HCC). Aims: The aim of this meta-analysis was to compare the effectiveness of combination of RFA and TACE with that of RFA alone in patients with HCC. Methods: Randomized controlled trials and retrospective cohort studies comparing RFA plus TACE with RFA alone for HCC were included into this meta-analysis. Study quality was rated with a standardized scale and the strength of evidence was also rated by using the Grading of Recommendations Assessment, Development, and Evaluation system (GRADE system). Results: Meta-analyses showed that the combination of RFA and TACE was obviously associated with higher survival rates (OR1-year = 2.06, 95 % CI 1.46-2.91, P < 0.001; OR3-year = 1.93, 95 % CI 1.18-3.15, P = 0.009; OR5-year = 1.87, 95 % CI 1.23-2.83, P = 0.003). The overall quality of the evidence was judged to be low by using the GRADE system. Conclusions: The combination of TACE with RFA can improve the overall survival rate and provides better prognosis for patients with HCC, but more randomized controlled trials using large sample sizes are needed to provide sufficient evidence. © 2013 Springer Science+Business Media New York.


PubMed | Peoples Hospital of Jiangbei
Type: Journal Article | Journal: Asian Pacific journal of cancer prevention : APJCP | Year: 2012

Studies of associations between genetic polymorphism of glutathione S-transferase T1(GSTT1) and risk of colorectal cancer (CRC) in Asian populations have reported controversial results. Thus, a meta-analysis was performed to clarify the effects of GSTT1 polymorphism on the risk of developing colorectal cancer.A literature search of PubMed and EMBASE up to June 7, 2011 was conducted and 13 eligible papers were finally selected, involving totals of 4,832 CRC cases and 7,045 controls. Subgroup analyses were performed according to the sample size and the research design with the software programs Review Manager (version 5.0.10) and STATA (version 9.2).Analyses of all relevant studies showed an increased CRC risk was significantly associated with the null genotypes of GSTT1 (OR=1.09, 95%CI=1.01-1.17, POR=0.027; I2=40.2%). Besides, a more obvious association was observed after heterogeneity was eliminated (OR=1.13, 95%CI 1.04-1.23, POR=0.002; I2=0.0%). Subgroup analyses and sensitivity analysis further identified an association in Asians.This meta-analysis demonstrated the GSTT1 null genotype to be associated with an increased risk of CRC in Asian populations.

Loading Peoples Hospital of Jiangbei collaborators
Loading Peoples Hospital of Jiangbei collaborators