Hong-bing H.,Peoples Hospital of Huangpi District
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology | Year: 2011
To study the expression and clinical significance of serum vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in children with acute leukemia (AL). The serum VEGF and bFGF level before chemotherapy from 40 cases of children with newly diagnosed AL, after 1 course of treatment from from 37 cases of children with complete remission (CR) and no- remission(NR) , and 40 cases of healthy children (control group) were detected by ELISA technology. Before treatment, the serum VEGF and bF-GF level of the AL group and different types of AL were significantly higher than the control group(P<0.05), while the serum VEGF and bFGF level were no significant difference between the different types of AL ( P > 0.05). Before treatment, the serum VEGF and bFGF level were no significant difference between the AL CR and NR children; After treatment, the serum VEGF and bFGF level of CR children decreased significantly, compared with the prior-treatment and NR children the different was significant ( P < 0. 05); While the serum VEGF and bFGF level of NR children were no significant difference between prior-treatment and post-treatment. The serum VEGF and bFGF level have high expression in children with AL, the serum VEGF and bFGF level can be used as indicators of AL efficacy, and are correlation with the prognosis of children with AL.
Cheng C.-L.,Peoples Hospital of Huangpi District
Chinese Journal of Interventional Imaging and Therapy | Year: 2014
Objective: To evaluate the image quality using image quality enhancement (IQE) algorithm based on projection data of high pitch scan. Methods: (1)Original data of a adult head specimen was obtained. And a subjective evaluation of image artifacts was done. (2)Sixty patients who underwent head CT scanning were selected, and the parameters were set as follow: 30 patients were scanned with pitch 1:1.75, and the other with pitch 1: 1.375, 120 kVp, 200 mAs. Traditional technique and IQE were both used to reconstruct images. The image quality and standard deviation (SD) value were measured and compared, and the data were quantitatively analyzed. Results: (1)Specimen data: Windmill artifacts in images reconstructed with IQE were less than those reconstructed with traditional technique. (2)Clinical data: With pitch 1:1.75, image artifact was lower with IQE reconstruction, and image quality using IQE was higher than that using traditional technique. SD value was 27.42 ± 3.70 and 20.11 ± 4.20 respectively for IQE and traditional technique (t=4.913, P<0.05). Conclusion: IQE can be used to reconstruct images with high quality and less image noise.
Deng Y.S.,Peoples Hospital of Huangpi District
Zhonghua nan ke xue = National journal of andrology | Year: 2013
To observe the therapeutic effect of Qilin Pills combined with bromocriptine on idiopathic hyperprolactinemic (HPRL) oligoasthenospermia. We conducted a randomized controlled study on 40 cases of idiopathic HPRL oligoasthenospermia, who were equally assigned to a trial group and a control group to be treated with Qilin Pills (6 g tid) combined with bromocriptine and bromocriptine alone, respectively, both for a course of 12 weeks. Then we observed the changes in the semen volume, sperm concentration, sperm motility and the levels of serum prolactin and testosterone, and compared the therapeutic results between the two groups before and after medication. Compared with the parameters before medication, both the trial and the control group showed significant improvement after treatment in sperm concentration ([11.60 +/- 3.90] x 10(6)/ml vs [28.10 +/- 13.50] x 10(6)/ml and [12.03 +/- 4.10] x 10(6)/ml vs [18.85 +/- 8.50] x 10(6)/ml), the percentage of grade a sperm ([8.75 +/- 6.65]% vs [24.35 +/- 13.25 ]% and [8.70 +/- 6.70] % vs [19.65 +/- 10.05]%), the percentage of grade a + b sperm ( [28.45 +/- 11.35]% vs [45.80 +/- 16.55]% and [27.65 +/- 10.65]% vs [35.66 +/-13.25]%), and sperm motility ([38.22 +/- 16.35]% vs [60.05 +/- 20.65]% and [37.25 +/- 15.75 ]% vs [52.65 +/- 18.25 ]%) (all P<0.01). No significant differences were found in semen volume (P>0.05). The serum prolactin levels were significantly decreased in the trial and control groups ([152.00 +/- 22.32] and [160.45 +/- 26.65] mIU/L), as compared with premedication ([482.25 +/- 65.32] and [477.32 +/- 60.25] mIU/L) (P<0.01), while the serum testosterone levels were remarkably higher ([16.35 +/- 5.52] and [11.15 +/- 4.65] nmol/L) than before treatment ([3.75 +/- 1.10] and [4.05 +/- 1.30] nmol/L) (P<0.01). There were no statistically significant differences in the serum prolactin and testosterone levels between the two groups after treatment (P>0.05). Qilin Pills combined with bromocriptine have a significantly better efficacy than bromocriptine alone in the treatment of idiopathic HPRL oligoasthenospermia.
Zhou H.-X.,Peoples Hospital of Huangpi District
Chinese Journal of Tissue Engineering Research | Year: 2015
BACKGROUND: Proinflammatory transcription factors and inflammatory factors play an important role in the occurrence of alcoholic liver disease. However, early growth response factor 1 is one of the key factors of starting inflammation. OBJECTIVE: To investigate and analyze the effects of silymarin on early growth response factor1 in rat models of alcoholic fatty liver. METHODS: The rat models were established using the methods of feeding with high fat diet and intragastrically administering alcohol, in total 8 weeks. Silymarin intervention at high and low doses (200,100 mg/kg) was given after each gavage. The normal group was set as comparison. RESULTS AND CONCLUSION: Serological indicator detection and hematoxylin-eosin staining results showed that compared with the model group, the body weight of rats was increased (P < 0.05); serum aspartate aminotransferase, alanine aminotransferase activity, early growth response factor 1 and tumor necrosis factor-α expression in the liver tissue were decreased (P < 0.05); pathological grading results were superior in the high-dose silymarin group to in the other groups (P < 0.01). The results confirm that high dose of silymarin can protect the liver function of rats, reduce the occurrence of liver function damage, which may be associated with the inhibition on the early growth response factor 1 in the body of rats, thereby reducing the tumor necrosis factor-α formation, but the specific mechanism remains to be further studied. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.
Zhen Y.,Peoples Hospital of Huangpi District
Chinese Journal of Tissue Engineering Research | Year: 2014
BACKGROUND: Large randomized controlled clinical trials have shown that drug-eluting stents has a lower restenosis rate compared with bare-metal stents, but the drug-eluting stents cannot reduce major cardiovascular events and death rates, and long-term follow-up of clinical registries show the drug-eluting stents even may increase late stent thrombosis events. OBJECTIVE: To evaluate the incidence of stenosis and adverse reactions after treatment with biodegradable, non-biodegradable drug-eluting stents and bare-metal stents in patients after myocardial infarction. METHODS: We retrospectively analyzed the clinical data of 236 cases of acute myocardial infarction, in which 79 cases were treated with biodegradable sirolimus-eluting stents, 83 cases treated with non-biodegradable sirolimus-eluting stents, and 74 cases treated with bare metal stents. Then, we compared late lumen loss and restenosis within 12 months after stent implantation and major adverse cardiac reactions within 24 months after stent implantation. RESULTS AND CONCLUSION: After 12 months, the late lumen loss of the bare stent group was significantly higher than that of biodegradable and non-biodegradable sirolimus-eluting stent groups (P < 0.05), but the difference in stent restenosis rate (P > 0.05). After 24 months, there were no differences in death, cardiac death, recurrent myocardial infarction, target vessel revascularization, target lesion revascularization, major adverse cardiac events and stent thrombosis events among the three groups. These three kinds of stents need to be further studied in their long-term efficacy and safety as percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. © 2014, Journal of Clinical Rehabilitative Tissue Engineering Research. All Rights Reserved.