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Guo J.,Dalian Medical University | Zu G.,Peoples Hospital of Huaibei City | Wang Z.-Y.,Dalian Medical University
Journal of Dalian Medical University | Year: 2013

Gastrointestinal stromal tumor (GIST) is the most common tumors derived from mesenchymal tissue in digestive tract, With the development of immunohistochemical, ultrastructural and molecular biology, GIST has become one of the hot research of digestive tract tumor in recent years. GISTs occur in the stomach and small intestine commonly, and upper abdominal discomfort, abdominal mass and gastrointestinal bleeding are main clinical manifestations. Endoscopic ultrasonography is a sensitive screening method, and diagnosis confirmed by postoperative pathology and immunohistochemistry. CD117 and CD34 are the most characteristic markers. GISTs are insensitive to chemotherapy and radiotherapy. Surgical and molecular targeted drug therapy are the primary treatments for GISTs, and its prognosis associated with tumor size, split factor and tumor location, and so on. The epidemiology, clinical diagnosis, treatment, and prognosis of GIST are reviewed in this article.

Wang Z.-G.,Ultrasonic Examination Center | Xu C.-M.,Ultrasonic Examination Center | Zhou F.,Ultrasonic Examination Center | Jia G.-F.,Endoscopy Center | And 6 more authors.
Chinese Journal of Medical Imaging Technology | Year: 2014

Objective: To evaluate the performances of gastric mesenchymal tumor (GMT) by transabdominal 2-dimensional ultrasound (2D), CDFI, dynamic three-dimension surface imaging (4D) and 3-dimensional color Doppler imaging (3D-CDI). Methods: Forty-five cases of GMT underwent combined ultrasonic examinations, and ultrasonic findings were retrospectively analyzed, according to which the patients were divided into group A (benign or probably benign), group B (low medium risk) or group C (high risk or malignant). Results: The accordance rate of preoperative ultrasonic diagnosis for tumor location, growth mode, physical state, origin, pathological types and being benign or malignant was 95.56% (43/45), 95.56% (43/45), 91.11% (41/45), 93.33% (42/45), 62.22% (28/45) and 77.33% (33/45), respectively. The differences of tumor' size among three groups were statistically significant, so were differences of echoes between group A and B, as well as between A and C (P<0.05). Conclusion: GMT can be early detected with combined ultrasonic technologies.

Zu G.,Peoples Hospital of Huaibei City | Guo J.,Dalian Medical University | Wang Z.-Y.,Dalian Medical University
Journal of Dalian Medical University | Year: 2012

With the "breast cancer is a systemic disease" proposed and the development of evidence-based medicine, the treatment mode of breast cancer has changed from the previous rely on surgery solely to multidisciplinary treatment, Also concept of surgical treatment of breast cancer from "maximum tolerated treatment" more than a century ago to "minimum effective treatment" under the multidisciplinary treatment. Breast conserving surgery and combined therapy has become one of the main methods for treatment of early breast cancer. This article will review breast conserving surgery from surgical mode, surgical technical, indications and contraindications, treatment effection and problems in recent years.

Guo J.,Dalian Medical University | Zu G.,Peoples Hospital of Huaibei City | Wang Z.-Y.,Dalian Medical University
Journal of Dalian Medical University | Year: 2012

[Objective] To explore the clinical characteristics and prognosis of MBC. [Methods] Retrospective study the clinical data of eighteen cases of MBC hospitalized in the First Affiliated Hospital of Dalian Medical University from January 2004 to October 2011, Modified radical mastectomy were performed in 16 cases, whereas simple mastectomy and SLNB were performed in 2 eases. The clinical features, treatment measures and prognosis were reviewed and analyzed. [Results] Postpoerative local numbness in 5 cases, upper extremity edema in 1 case, subcutaneous fluid in 4 cases; Pathological types included 7 cases of simple type and 11 cases of mixed type. Metastasis of axillary lymph nodes occurred in 4 cases, accounting for 22.22% of the 18 eases. Stage I-II was found in 15 cases, accounting for 83.33%, stage III in 3 cases. Fifteen cases were followed up for 16 months to 5 years with the follow-up rate of 83.33%. All patients were still living and in good health in the follow-up period. [Conclusion] For MBC, the growth is slow and the metastatic rate is low, modified radical mastectomy or simple mastectomy and SLNB were performed, and underwent chemotherapy after operation, the prognosis is better.

Zhen Z.,Peoples Hospital of Huaibei City | Shen C.,Peoples Hospital of Huaibei City | Tao X.,Peoples Hospital of Huaibei City | Li W.,Peoples Hospital of Huaibei City | Zhao M.,Peoples Hospital of Huaibei City
Cancer Research and Clinic | Year: 2014

Objective: To compare the efficacy, toxicity and prognosis on treating advanced non-small-cell lung cancer (NSCLC) between using weekly docetaxel (DOC) and using DOC associated with nedaplatin(NDP). Methods: 56 cases of NSCLC patients were retrospectively analyzed. Group A included 34 cases who were treated with weekly DOC (35 mg/m2, d1,8). Group B included 22 cases who were treated with DOC associated with NDP (DOC 35 mg/m2, d1,8, NDP 80 mg/m2, d2). One treatment cycle was 21 days. Efficacy, toxicity and prognosis were evaluated after 2 treatment cycles. Results: RR of group A was 8.8% (3/34). RR of group B was 27.3% (6/22). DCR of group A was 50.0% (17/34). DCR of group B was 63.6% (14/22). PFS of group A was 2.3 months. PFS of group B was 5.1 months. OS of group A was 8.7 months. OS of group B was 10.5 months. 1-year survival rate of group A was 26.5%. 1-year survival rate of group B was 31.8%. The above comparisons were not statistically different (all P > 0.05). In adverse reactions, hematologic toxicity in group B was greater than that in group A (χ2 = 4.877, P = 0.027). Other adverse reactions such as gastrointestinal reactions, fatigue and so on were grade I-II. Conclusions: The treatment of weekly DOC used in advanced NSCLC is safe, effective an low toxicity. There are no significant difference of RR and PFS between single DOC and DOC associated with NDP.

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