Peoples Hospital of Guilin

Guilin, China

Peoples Hospital of Guilin

Guilin, China
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Yin R.-X.,Guangxi Medical University | Wu D.-F.,Guangxi Medical University | Wu J.-Z.,Guangxi Medical University | Cao X.-L.,Guangxi Medical University | And 6 more authors.
International Journal of Biological Sciences | Year: 2012

The interactions of single nucleotide polymorphisms (SNPs) and cigarette smoking on blood pressure levels are limited. The present study was undertaken to detect nine lipid-related SNPs and their interactions with cigarette smoking on blood pressure levels. Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransfer-ase-1 (ACAT-1) rs1044925, low density lipoprotein receptor (LDL-R) AvaII, hepatic lipase gene (LIPC) -250G>A, endothelial lipase gene (LIPG) 584C>T, methylenetetrahydrofolate reductase (MTHFR) 677C>T, proprotein convertase subtilisin-like kexin type 9 (PCSK9) E670G, peroxisome proliferator-activated receptor delta (PPARD) +294T>C, and Scavenger receptor class B type 1 (SCARB1) rs5888 was performed in 935 nonsmokers and 845 smokers. The interactions were detected by factorial regression analysis. The frequencies of genotypes (ACAT-1 and LIPG), alleles (ABCA-1), and both genotypes and alleles (LDL-R, LIPC, PPARD and SCARB1) were different between nonsmokers and smokers (P < 0.05-0.001). The levels of pulse pressure (PP, ABCA-1), and systolic, diastolic blood pressure (SBP, DBP) and PP (LIPC) in nonsmokers were different among the genotypes (P < 0.01-0.001). The levels of SBP (ABCA-1, ACAT-1, LIPG and PCSK9), DBP (ACAT-1, LDL-R, LIPC, PCSK9 and PPARD), and PP (LIPC, LIPG, MTHFR and PCSK9) in smokers were dif-ferent among the genotypes (P < 0.01-0.001). The SNPs of ABCA-1, ACAT-1 and PCSK9; ACAT-1, LDL-R, MTHFR and PCSK9; and ABCA-1, LIPC, PCSK9 and PPARD were shown interactions with cigarette smoking to influence SBP, DBP and PP levels (P < 0.05-0.001); respectively. The differences in blood pressure levels between the nonsmokers and smokers might partly result from different interactions of several SNPs and cigarette smoking.


Yin R.-X.,Guangxi Medical University | Wu J.-Z.,Guangxi Medical University | Liu W.-Y.,Guangxi Medical University | Wu D.-F.,Guangxi Medical University | And 7 more authors.
American Journal of Hypertension | Year: 2012

Background Sex differences in hypertension are not well known. The present study was undertaken to detect the association of nine lipid-related gene polymorphisms and blood pressure variation beween men and women in the Bai Ku Yao population. Methods Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low-density lipoprotein receptor (LDL-R) AvaII, hepatic lipase gene (LIPC)-250G0.05-0.001). The genotypic frequencies of ABCA-1, ACAT-1, LDL-R, LIPC, MTHFR, PPARD, and SCARB1 in males and ABCA-1, LDL-R, LIPC, LIPG, and MTHFR in females were different between normotensives and hypertensives (P>0.05-0.001). Systolic blood pressure (SBP) levels in male hypertensives were different among the LIPC, LIPG, PCSK9, and SCARB1 genotypes (P>0.05-0.01); and diastolic blood pressure (DBP) levels were different among the ABCA-1, LDL-R, LIPC, LIPG, MTHFR, PCSK9, and PPARD genotypes (P>0.05-0.001). SBP levels in female hypertensives were different among the LIPC, MTHFR, PCSK9, and PPARD genotypes (P>0.05-0.01); and DBP levels were different among ABCA-1, ACAT-1, MTHFR, PCSK9, PPARD, and SCARB1 genotypes (P 0.05-0.001). The correlations between these polymorphisms and blood pressure levels were also observed. Conclusions Sex differences in blood pressure levels in this population may partly attribute to the differences in some lipid-related gene polymorphisms. © 2012 American Journal of Hypertension, Ltd.


Sun Y.-g.,Peoples Hospital of Guilin | Huang B.-t.,Peoples Hospital of Guilin | Yu J.,Peoples Hospital of Guilin
Chinese Journal of Tissue Engineering Research | Year: 2012

BACKGROUND: Inferior vena cava filter can prevent pulmonary embolism in clinical practice. OBJECTIVE: To explore the biocompatibility, safety, surgical indications, and causes and preventive measures of related complications of inferior vena cava filter implantation in preventing pulmonary embolism. METHODS: A retrospective analysis was performed in 96 patients in the People's Hospital of Guilin from 2001 to 2011 receiving vena cava filter implantation for treatment of deep venous thrombosis. RESULTS AND CONCLUSION: Fifty-five patients were implanted with permanent filter, 23 cases were implanted with recyclable filter, and 18 patients were with temporary filter. All the patients were followed up for 8 months to 7 years. Pulmonary embolism occurred in one patient, filter tilting happened in two cases, and slight host response could be seen in one case, all of the above did not influence the treatment. It is indicated that inferior vena cava filter can efficiently prevent pulmonary embolism in clinical practice with good biocompatibility and safety.


PubMed | Peoples Hospital of Guilin
Type: Journal Article | Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics | Year: 2010

High noise levels (>70 dB) in the neonatal intensive care unit (NICU) are common in some primary hospitals. This study aimed to investigate the noise in the NICU on auditory system and intelligence development in premature infants.One hundred premature infants with respiratory distress syndrome who needed mechanical ventilation therapy were randomly divided into observation and control groups according to the use of earmuffs. The duration of mechanical ventilation therapy lasted for 2 to 15 days in the two groups. After weaning from mechanical ventilator, the auditory brainstem response, cranial B-ultrasonography, and the intelligence development assessment were performed.The percentage of total (23% vs 47%) and mild hearing loss (15% vs 35%) in the observation group was significantly lower than that in the control group (p<0.05) 2 to 3 days after weaning from mechanical ventilator. The incidence of periventricular hemorrhage intraventricular hemorrhage (PVH-IVH) or periventricular leukomalacia (PVL) in the observation group was significantly lower than that in the control group (21% vs 42%; p<0.05). The intelligence development assessment performed in the first 6 and 12 months of life showed that the mental development index and the psychomotor development index in the observation group were much higher than those in the control group (p<0.05).The noise in the NICU can result in mild hearing loss and retardation of intelligence development and increase the incidence of PVH-IVH and PVL in premature infants. The use of earmuff may reduce the adverse events.

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