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Wei S.,Guangxi Medical University | Wang Y.,Peoples Hospital of Guangxi Zhuang Autonomous Region | Xu H.,Guangxi Medical University | Kuang Y.,Guangxi Medical University
Oncology Letters | Year: 2015

The aim of the present study was to screen out the biomarkers associated with chemoresistance in ovarian carcinomas and to investigate the molecular mechanisms. microRNA (miRNA) expression data was obtained from published microarray data of the GSE43867 dataset from Gene Expression Omnibus (GEO), including the data of 86 chemotherapy‑treated patients with serous epithelial ovarian carcinomas (response group, 36 complete response cases and 12 partial response cases; non‑response group, 10 stable cases and 28 progressive disease cases), and identification of differentially‑expressed miRNAs were conducted with a GEO2R online tool based on R language. TargetScan 6.2 was used to predict the targets of differentially‑expressed miRNAs. Protein‑protein interaction network analysis was conducted by STRING 9.1, while functional enrichment [Gene Ontology (GO) biological process terms] and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted by GeneCodis3 for the target genes. A total of 6 differentially‑expressed miRNAs were screened out, with 317 target genes obtained. It was found that 67 interactions existed among 76 genes/proteins through the PPI network analysis, and that 6 of these were potential key genes (PIK3R5, MAPK3, PTEN, S1PR3, BDKRB2 and NCBP2). The main biological processes involved in chemoresistant ovarian carcinoma were apoptosis, programmed cell death, cell migration, cell death and cell motility. The miRNA target genes were found to be associated with the ErbB signaling pathway, the gonadotropin‑releasing hormone signaling pathway and other pathways in cancer. IK3R5, MAPK3 and PIK3R5 are involved in the majority of GO terms and KEGG pathways associated with chemoresistance in ovarian carcinoma. © 2015 Spandidos Publications. All rights reserved.


Hu R.-T.,Guangxi Medical University | Liu J.,Peoples Hospital of Guangxi Zhuang Autonomous Region | Zhou Y.,Minerva Foundation Institute for Medical Research | Hu B.-L.,Guangxi Medical University
Pakistan Journal of Medical Sciences | Year: 2015

Background and Objective: The association between smoking and clinical outcomes after coronary stenting is controversial. The aim of this meta-analysis was to assess the association between smoking and in stent restenosis (ISR), major adverse cardiac events (MACE), or major adverse cardiac and cerebrovascular events (MACCE) after coronary stenting. Methods: A search for studies published before December 2014 was conducted in PubMed, Embase, and Cochrane library. An inverse random weighted meta-analysis was conducted using logarithm of the odds ratio (OR) and its standard error for each study. Results: Ten studies investigated the association between smoking and ISR. Overall, smoking was not associated with ISR (OR: 1.05, 95% CI: 0.79–1.41; I2 = 47.8%). Subgroup analysis also failed to show a significant association between smoking and ISR risk regardless of bare metal stent (BMS) and drug-eluting stent (DES) implantation. Eight studies explored the association between smoking and MACE, but no association was found (OR: 0.92, 95% CI: 0.77–1.10; I2 = 25.5%), and subgroup analysis revealed that no distinct difference was found between BMS and DES implantation. Three studies investigated the association between smoking and MACCE and significant association was found (OR: 2.09, 95% CI: 1.43–3.06; I2 = 21.6%). Conclusions: Our results suggest that in patients undergoing percutaneous coronary intervention with stent implantation, smoking is not associated with ISR and MACE; however, smoking is an independent risk factor for MACCE. © 2015, Professional Medical Publications. All rights reserved.


Liu C.-B.,Guangxi Medical College | Liang G.,Guangxi Medical College | Zheng Q.-F.,Peoples Hospital of Guangxi Zhuang Autonomous Region | Liang H.-P.,Guangxi Medical College | And 8 more authors.
World Chinese Journal of Digestology | Year: 2014

AIM: To conduct an epidemiological survey of the prevalence of and risk factors for irritable bowel syndrome (IBS) in community residents in Nanning, Guangxi Zhuang Autonomous Region.METHODS: Cluster random sampling was used to collect samples from community residents in Nanning, and data were collected by face-to-face interview according to the Rome III diagnostic questionnaire. IBS was diagnosed according to the Scoring Algorithm for Rome III diagnostic questionnaire for adults. The prevalence of IBS was computed and the risk factors for IBS were analyzed.RESULTS: A total of 2900 questionnaires were issued and 2773 were returned, with a response rate of 95.62%. The prevalence of IBS among the community residents in Nanning was 6.53%. The prevalence of IBS differed by gender, with a higher prevalence in females than in males (OR = 1.419). Marinated seafood, cold food, fruits, dairy products, and bad mood were found to be correlated with IBS by multiple logistic regression analysis (P < 0.05).CONCLUSION: The prevalence of IBS among the community residents in Nanning is 6.53%. The factors that affect this disease mainly include gender, marinated seafood, cold food, fruits, dairy products, and bad mood. © 2014 Baishideng Publishing Group Inc. All rights reserved.


Li M.-Y.,Peoples Hospital of Guangxi Zhuang Autonomous Region | Hu X.-X.,Peoples Hospital of Guangxi Zhuang Autonomous Region
Medical Oncology | Year: 2015

Cervical cancer is one of the most common malignant tumors in women, and numerous studies have associated the disease with changes in microRNA (miRNA) expression. This meta-analysis aimed to consolidate and assess the results of these studies in order to identify potential miRNA biomarkers of cervical cancer. We systematically searched the literature for studies comparing miRNA expression between cervical cancer tissues and normal cervical tissues, and we meta-analyzed the result of 27 studies comprising 1,132 cancer samples and 943 normal samples. We used a vote-counting strategy that took into account total sample and mean fold-change, in order to comprehensively assess associations between certain miRNAs and cervical cancer occurrence and progression. The studies described 195 miRNAs that were significantly up-regulated and 96 microRNAs that were down-regulated in cervical cancer tissues (stage I–IV) relative to normal cervical tissues. Vote-counting analysis showed that up-regulation was most consistently reported for miR-20a and miR-21 (four studies), followed by miR-10a, miR-15b, miR-20b, miR-141, miR-200a, and miR-224 (three studies). Down-regulation was reported most consistently for miR-143 (seven studies), followed by miR-203 and miR-145 (six studies). Fourteen miRNA, respectively, showed a significantly correlated lymphatic node metastasis in eight studies. This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers. © 2015, Springer Science+Business Media New York.


Li X.W.,Peoples Hospital of Guangxi Zhuang Autonomous Region | Lin Y.Z.,Peoples Hospital of Guangxi Zhuang Autonomous Region | Lin H.,Peoples Hospital of Guangxi Zhuang Autonomous Region | Huang J.B.,Peoples Hospital of Guangxi Zhuang Autonomous Region | And 8 more authors.
Brazilian Journal of Medical and Biological Research | Year: 2016

Cardioplegic reperfusion during a long term ischemic period interrupts cardiac surgery and also increases cellular edema due to repeated solution administration. We reviewed the clinical experiences on myocardial protection of a single perfusion with histidine-tryptophan-ketoglutarate (HTK) for high-risk patients with severe pulmonary arterial hypertension associated with complex congenital heart disease. This retrospective study included 101 high-risk patients undergoing arterial switch operation between March 2001 and July 2012. We divided the cohort into two groups: HTK group, myocardial protection was carried out with one single perfusion with HTK solution; and St group, myocardial protection with conventional St. Thomas’ crystalloid cardioplegic solution. The duration of cardiopulmonary bypass did not differ between the two groups. The mortality, morbidity, ICU stay, post-operative hospitalization time, and number of transfusions in HTK group were lower than those in St group (P<0.05). Univariate and multivariate analysis showed that HTK is a statistically significant independent predictor of decreased early mortality and morbidity (P<0.05). In conclusion, HTK solution seems to be an effective and safe alternative to St. Thomas’ solution for cardioplegic reperfusion in high-risk patients with complex congenital heart disease. © 2016, Associacao Brasileira de Divulgacao Cientifica. All rights reserved.

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