Li Y.-Q.,Peoples Hospital Of Guangxi Zhuang Autonomous Region |
Ye L.-H.,Laibing Maternal and Neonatal Hospital |
Mo Y.,Peoples Hospital Of Guangxi Zhuang Autonomous Region
Hemoglobin | Year: 2016
Hb Köln (HBB: c.295G>A) is an unstable β-globin gene variant with a GTG>ATG substitution at codon 98. This variant is quite frequent in Europe and the USA but rare in China. It can easily be misdiagnosed as Hb Constant Spring (Hb CS; HBA2: c.427T>C) by high performance liquid chromatography (HPLC), but detection and quantification of both Hb Köln and degraded Hb Köln by capillary electrophoresis (CE) are possible. Thus, we concluded that CE was the preferred method for Hb Köln detection. © 2016, © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Xie T.-H.,University of Sichuan |
Zeng J.-C.,University of Sichuan |
Li Z.-H.,Peoples Hospital Of Guangxi Zhuang Autonomous Region |
Wang L.,University of Sichuan |
And 4 more authors.
Pain Physician | Year: 2017
Background: The new surgical procedure of full-endoscopic interlaminar lumbar discectomy (FILD) has achieved favorable effects in the treatment of lumbar disc herniation (LDH). Along with the wide range of applications of FILD, a series of complications related to the operation has gradually emerged. Objective: To describe the types, incidences, and characteristics of complications following FILD and to explore preventative and treatment measures. Study Design: Retrospective, observational study. Setting: A spine center affiliated with a large general hospital. Method: In total, 479 patients with LDH underwent FILDs that were performed by a single experienced spine surgeon between January 2010 and April 2013. Data concerning the complications were recorded. Results: All 479 cases successfully underwent the procedure. A total of 482 procedures were completed. The mean follow-up time was 44.3 months with a range of 24 to 60 months. The average patient age was 47.8 years with a range of 16 to 76 years. Twenty-nine (6.0%) related complications emerged, including 3 cases (0.6%) of incomplete decompression in which the symptoms gradually decreased following 3 – 6 weeks of conservative treatment, 2 cases (0.4%) of nerve root injury in which the patients recovered well following 1 – 3 months of neurotrophic drug and functional exercise treatment, 15 cases (3.1%) of paresthesia that gradually improved following 1 – 8 weeks of rehabilitation exercises and treatment with mecobalamin and pregabalin, and 9 cases of recurrent herniation (1.9%). The latter condition was controlled in 4 cases with a conservative method, and 5 of these cases underwent reoperations that included 3 traditional open surgeries and 2 FILDs. Furthermore, the complication rate for the first 100 cases was 18%. This rate decreased to 2.9% for cases 101 – 479. The incidence of L4-5 herniation (8.2%) was significantly greater than that of L5-S1 (4.5%). Limitations: This is a retrospective study, and some bias exists due to the single-center study design. Conclusion: FILD is a surgical approach that has a low complication rate. Incomplete decompression, nerve root injury, paresthesia, and recurrent herniation were observed in our study. Some effective measures can prevent and reduce the incidence of the complications including strict indications for surgery, a thorough action plan, and a high level of surgical skill. © 2017, American Society of Interventional Pain Physicians. All rights reserved.
Wu F.,Centers for Disease Control and Prevention |
Chi Y.,Peoples Hospital Of Guangxi Zhuang Autonomous Region
Industrial Health | Year: 2015
With the explosive economic growth and social development, China’s regulatory system of occupational health and safety now faces more and more challenges. This article reviews the history of regulatory system of occupational health and safety in China, as well as the current reform of this regulatory system in the country. Comprehensive, a range of laws, regulations and standards that promulgated by Chinese government, duties and responsibilities of the regulatory departments are described. Problems of current regulatory system, the ongoing adjustments and changes for modifying and improving regulatory system are discussed. The aim of reform and the incentives to drive forward more health and safety conditions in workplaces are also outlined. © 2015 National Institute of Occupational Safety and Health.
Li M.-Y.,Peoples Hospital Of Guangxi Zhuang Autonomous Region |
Li M.-Y.,Changsha Hospital for Maternal and Child Health Care |
Hu X.-X.,Peoples Hospital Of Guangxi Zhuang Autonomous Region |
Zhong J.-H.,Guangxi Medical University |
And 2 more authors.
Oncology Letters | Year: 2016
The purpose of the current review was to examine whether systematic lymphadenectomy is safe and effective for treating early-stage endometrial cancer. PubMed, Embase, the Cochrane Library and the China National Knowledge Infrastructure databases were systematically searched during April 2014 to identify studies comparing the use of systematic lymphadenectomy and no systematic lymphadenectomy in parallel for the treatment of early-stage endometrial cancer. A total of 13 eligible studies involving 51,155 patients were included in this review. The median overall survival (OS) rate at 5 years following lymphadenectomy was 90% (range, 73.1-98.3%) for patients undergoing the systematic procedure and 88.2% (range, 68-98.4%) for patients not undergoing the systematic procedure. For the two types of lymphadenectomy, OS has tended to improve over the last 20 years. The combined rate of disease-free and progression-free survival was higher in patients who underwent systematic lymphadenectomy, and the recurrence rate was lower. In particular, systematic lymphadenectomy was associated with markedly higher OS than the non-systematic procedure for patients with intermediate- and high-risk endometrial cancer when ≥11 lymph nodes were removed. Systematic lymphadenectomy demonstrates clinical benefit in patients with early-stage endometrial cancer and should thus be a standard treatment option. In conclusion, systematic lymphadenectomy leads to higher OS than no systematic lymphadenectomy in intermediate- and high-risk patients with early-stage endometrial cancer, particularly when the procedure removes ≥11 lymph nodes. © 2016, Oncology Letters. All Rights Reserved.
Hu R.-T.,Guangxi Medical University |
Liu J.,Peoples Hospital Of Guangxi Zhuang Autonomous Region |
Zhou Y.,Minerva Foundation Institute for Medical Research |
Hu B.-L.,Guangxi Medical University
Pakistan Journal of Medical Sciences | Year: 2015
Background and Objective: The association between smoking and clinical outcomes after coronary stenting is controversial. The aim of this meta-analysis was to assess the association between smoking and in stent restenosis (ISR), major adverse cardiac events (MACE), or major adverse cardiac and cerebrovascular events (MACCE) after coronary stenting. Methods: A search for studies published before December 2014 was conducted in PubMed, Embase, and Cochrane library. An inverse random weighted meta-analysis was conducted using logarithm of the odds ratio (OR) and its standard error for each study. Results: Ten studies investigated the association between smoking and ISR. Overall, smoking was not associated with ISR (OR: 1.05, 95% CI: 0.79–1.41; I2 = 47.8%). Subgroup analysis also failed to show a significant association between smoking and ISR risk regardless of bare metal stent (BMS) and drug-eluting stent (DES) implantation. Eight studies explored the association between smoking and MACE, but no association was found (OR: 0.92, 95% CI: 0.77–1.10; I2 = 25.5%), and subgroup analysis revealed that no distinct difference was found between BMS and DES implantation. Three studies investigated the association between smoking and MACCE and significant association was found (OR: 2.09, 95% CI: 1.43–3.06; I2 = 21.6%). Conclusions: Our results suggest that in patients undergoing percutaneous coronary intervention with stent implantation, smoking is not associated with ISR and MACE; however, smoking is an independent risk factor for MACCE. © 2015, Professional Medical Publications. All rights reserved.
Wei S.,Guangxi Medical University |
Wang Y.,Peoples Hospital Of Guangxi Zhuang Autonomous Region |
Xu H.,Guangxi Medical University |
Kuang Y.,Guangxi Medical University
Oncology Letters | Year: 2015
The aim of the present study was to screen out the biomarkers associated with chemoresistance in ovarian carcinomas and to investigate the molecular mechanisms. microRNA (miRNA) expression data was obtained from published microarray data of the GSE43867 dataset from Gene Expression Omnibus (GEO), including the data of 86 chemotherapy‑treated patients with serous epithelial ovarian carcinomas (response group, 36 complete response cases and 12 partial response cases; non‑response group, 10 stable cases and 28 progressive disease cases), and identification of differentially‑expressed miRNAs were conducted with a GEO2R online tool based on R language. TargetScan 6.2 was used to predict the targets of differentially‑expressed miRNAs. Protein‑protein interaction network analysis was conducted by STRING 9.1, while functional enrichment [Gene Ontology (GO) biological process terms] and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted by GeneCodis3 for the target genes. A total of 6 differentially‑expressed miRNAs were screened out, with 317 target genes obtained. It was found that 67 interactions existed among 76 genes/proteins through the PPI network analysis, and that 6 of these were potential key genes (PIK3R5, MAPK3, PTEN, S1PR3, BDKRB2 and NCBP2). The main biological processes involved in chemoresistant ovarian carcinoma were apoptosis, programmed cell death, cell migration, cell death and cell motility. The miRNA target genes were found to be associated with the ErbB signaling pathway, the gonadotropin‑releasing hormone signaling pathway and other pathways in cancer. IK3R5, MAPK3 and PIK3R5 are involved in the majority of GO terms and KEGG pathways associated with chemoresistance in ovarian carcinoma. © 2015 Spandidos Publications. All rights reserved.
Hu G.,Guangzhou University |
Wu Y.,Peoples Hospital Of Guangxi Zhuang Autonomous Region |
Zhou Y.,Guangzhou University |
Yu Y.,Guangzhou University |
And 2 more authors.
Respiratory Care | Year: 2016
BACKGROUND: COPD is associated with cardiovascular and renal dysfunction. Cystatin C (CysC) is a biomarker of renal function and an independent risk factor for all-cause and cardiovascular mortality among elderly persons. The aim of the study was to examine the prognostic role of CysC for in-hospital mortality in subjects with a COPD exacerbation. METHODS: Upon admission, serum CysC levels and arterial blood gas analysis from 477 subjects with a COPD exacerbation were measured. Clinical characteristics were also recorded. A receiver operating characteristic curve analysis was used to determine the level of CysC that discriminated survivors from nonsurvivors. Univariate and multiple logistic regression analyses were used to identify the risk factors for in-hospital mortality. To reduce the influence of confounders, subgroup analyses were performed according to the comorbidities, including states of heart failure, renal dysfunction, and pH, PaCO2, and PaO2 levels. RESULTS: During the in-hospital period, 59 subjects died, and 418 subjects recovered. The decedent group showed lower pH (7.27 ± 0.17 vs 7.38 ± 0.06, P < .001), higher CysC (2.21 ± 1.05 mg/L vs 1.39 ± 0.54 mg/L, P < .001), higher PaCO2 (77 ± 39 mm Hg vs 48 ± 14 mm Hg, P < .001), and lower PaO2 (74 ± 32 mm Hg vs 84 ± 26 mm Hg, P < .001) levels. The area under the receiver operating characteristic curve for the CysC prediction of death was 0.77 (95% CI 0.70–0.84). CysC values ≥1.59 mg/L were associated with significantly higher inhospital mortality (relative risk 2 5.49, 95% CI 3.24 –9.32, P < .001). Multiple logistic regression analysis showed that pH <7.20, CysC ≥1.59 mg/L, and heart failure were independent predictors of in-hospital mortality. The subgroup analysis showed that the comorbid states of renal dysfunction, congestive heart failure, and the levels of pH, PaCO2, and PaO2 did not alter the conclusion that CysC was a mortality risk factor for subjects with a COPD exacerbation. CONCLUSION: CysC was a strong and independent risk factor for hospital mortality secondary to COPD exacerbation. © 2016 Daedalus Enterprises.
Tang Y.-T.,Peoples Hospital Of Guangxi Zhuang Autonomous Region |
Yu N.,Peoples Hospital Of Guangxi Zhuang Autonomous Region |
Shen Y.,Peoples Hospital Of Guangxi Zhuang Autonomous Region
World Chinese Journal of Digestology | Year: 2016
Aim: To evaluate the clinical effects of early bedside blood filtration in the treatment of acute severe pancreatitis. Methods: Fifty-four patients with acute severe pancreatitis treated in People’s Hospital of Guangxi Zhuang Autonomous Region from October 2013 to October 2015 were randomly divided into either a control group or an observation group, with 27 patients in each group. The control group received conventional therapy, and the observation group received early bedside blood filtration on the basis of conventional therapy. Therapeutic effects were compared between the two groups. Results: After treatment, heart rate, respiratory rate, APACHE II score, interleukin-6, tumor necrosis factor-α, and C reactive protein significantly decreased while oxygenation index significantly increased in the two groups (P < 0.05). Heart rate, respiratory rate, APACHE II score, interleukin-6, tumor necrosis factor-α, and C reactive protein in the observation group were significantly lower than those in the control group (P < 0.05). Oxygenation index in the observation group was significantly higher than that in the control group (P < 0.05). Times to disappearance of abdominal pain, abdominal distension, and peritoneal irritation in the observation group were earlier than those in the control group (P < 0.05). Hospitalization time in the observation group was shorter than that in the control group (P < 0.05). Conclusion: Early bedside blood filtration has a significant effect in the treatment of acute severe pancreatitis, which is helpful to improve the prognosis of patients. © 2016 Baishideng Publishing Group Inc. All rights reserved.
Wu Y.,Peoples Hospital Of Guangxi Zhuang Autonomous Region |
Xu F.,Peoples Hospital Of Guangxi Zhuang Autonomous Region |
Huang H.,Peoples Hospital Of Guangxi Zhuang Autonomous Region |
Chen L.,Peoples Hospital Of Guangxi Zhuang Autonomous Region |
And 7 more authors.
Journal of Molecular Histology | Year: 2014
Cell cycle re-entry is one of the key processes in neuronal apoptosis. Previous studies have shown that Ski-interacting protein (SKIP) played an important role in cell cycle re-entry. However, its expression and function in optic nerve injury are still with limited acquaintance. To investigate whether SKIP is involved in retinal ganglion cells (RGCs) death, we performed an optic nerve crush (ONC) model in adult rats. Western blot analysis revealed that up-regulation of SKIP was present in retina at 5 days after ONC. Immunofluorescent labeling indicated that up-regulated SKIP was found mainly in RGCs. We also investigated co-localization of SKIP with active-caspase-3 and TUNEL (apoptotic markers) -positive cells in the retina after ONC. In addition, the expression of SKIP was increased in parallel with P53 and P21 in retina after ONC. All these results suggested that up-regulation of SKIP in the retina was associated with RGCs death after ONC. © 2014, Springer Science+Business Media Dordrecht.
Li M.-Y.,Peoples Hospital Of Guangxi Zhuang Autonomous Region |
Hu X.-X.,Peoples Hospital Of Guangxi Zhuang Autonomous Region
Medical Oncology | Year: 2015
Cervical cancer is one of the most common malignant tumors in women, and numerous studies have associated the disease with changes in microRNA (miRNA) expression. This meta-analysis aimed to consolidate and assess the results of these studies in order to identify potential miRNA biomarkers of cervical cancer. We systematically searched the literature for studies comparing miRNA expression between cervical cancer tissues and normal cervical tissues, and we meta-analyzed the result of 27 studies comprising 1,132 cancer samples and 943 normal samples. We used a vote-counting strategy that took into account total sample and mean fold-change, in order to comprehensively assess associations between certain miRNAs and cervical cancer occurrence and progression. The studies described 195 miRNAs that were significantly up-regulated and 96 microRNAs that were down-regulated in cervical cancer tissues (stage I–IV) relative to normal cervical tissues. Vote-counting analysis showed that up-regulation was most consistently reported for miR-20a and miR-21 (four studies), followed by miR-10a, miR-15b, miR-20b, miR-141, miR-200a, and miR-224 (three studies). Down-regulation was reported most consistently for miR-143 (seven studies), followed by miR-203 and miR-145 (six studies). Fourteen miRNA, respectively, showed a significantly correlated lymphatic node metastasis in eight studies. This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers. © 2015, Springer Science+Business Media New York.