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Chi H.,Guangdong Medical College | Lin X.,Guangdong Medical College | Huang H.,Guangdong Medical College | Zheng X.,Guangdong Medical College | And 2 more authors.
Archives of Medical Research | Year: 2014

Background and Aims: Studies of omega-3 supplementation in dialysis patients describe salutary effects on lipid profiles. However, study results have been inconsistent. The aim of this study was to evaluate the influence of omega-3 supplementation on serum lipids in chronic dialysis patients. Methods: A systematic literature search was performed to identify the relevant randomized controlled trials (RCTs) that investigated the effects of omega-3 supplementation on dialysis patients. The outcomes included the levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and albumin. Mean differences (MDs) and 95% confidence intervals (CIs) were calculated and heterogeneity was assessed with the I2 test. Results: A total of 678 patients from 14 trials were subjected to meta-analysis. Omega-3 supplementation could significantly decrease the levels of TG (MD, -34.8 mg/dL; 95% CI, -62.32 to -7.28) and LDL (MD, -7.15 mg/dL; 95% CI, -10.11 to -4.2). However, no statistically significant effects were observed for TC, HDL and albumin levels. In a subgroup meta-analysis, a statistically significant effect of omega-3 consumption on TG and LDL was observed in a short-term interventional duration and hemodialysis populations. Conclusion: Our findings indicate that omega-3 supplementation significantly reduced serum TG and LDL level in dialysis patients. However, there is no conclusive evidence that it can modulate the TC, HDL and albumin level. © 2014 IMSS.

Yang H.-J.,Sun Yat Sen University | Huang T.-J.,Second Peoples Hospital of Shenzhen | Yang C.-F.,Peoples Hospital of Gaozhou | Yang C.-F.,Sun Yat Sen University | And 10 more authors.
Virology Journal | Year: 2013

Background: Epstein-Barr virus (EBV) is an etiological cause of many human lymphocytic and epithelial malignancies. EBV expresses different genes that are associated with three latency types. To date, as many as 44 EBV-encoded miRNA species have been found, but their comprehensive profiles in the three types of latent infection that are associated with various types of tumors are not well documented. Methods. In the present study, we utilized poly (A)-tailed quantitative real-time RT-PCR in combination with microarray analysis to measure the relative abundances of viral miRNA species in a subset of representative lymphoid and epithelial tumor cells with various EBV latency types. Results: Our findings showed that the miR-BHRF1 and miR-BART families were expressed differentially in a tissue- and latency type-dependent manner. Specifically, in nasopharyngeal carcinoma (NPC) tissues and the EBV-positive cell line C666-1, the miR-BART family accounted for more than 10% of all detected miRNAs, suggesting that these miRNAs have important roles in maintaining latent EBV infections and in driving NPC tumorigenesis. In addition, EBV miRNA-based clustering analysis clearly distinguished between the three distinct EBV latency types, and our results suggested that a switch from type I to type III latency might occur in the Daudi BL cell line. Conclusions: Our data provide a comprehensive profiling of the EBV miRNA transcriptome that is associated with specific tumor cells in the three types of latent EBV infection states. EBV miRNA species represent a cluster of non-encoding latency biomarkers that are differentially expressed in tumor cells and may help to distinguish between the different latency types. © 2013 Yang et al.; licensee BioMed Central Ltd.

Zou Y.,Guangdong Medical College | Liao D.,Guangdong Medical College | Huang H.,Guangdong Medical College | Li T.,Peoples Hospital of Gaozhou | Chi H.,Guangdong Medical College
International Journal of Food Sciences and Nutrition | Year: 2015

Evidence from animal and observational studies has supported the beneficial effects of beta-glucan intake on glycemic control, but intervention studies in hypercholesterolemic crowd have generated mixed results and have not been systematically examined. In the present study, we aimed to quantitatively evaluate the relation between beta-glucan consumption from oats or barley on glycemic control in hypercholesterolemic individuals. A systematic literature review was conducted for relevant published randomized controlled trials studies (RCTs) in electronic databases through July 2014. Twelve trials with a total of 603 subjects were included in the meta-analysis. Beta-glucan consumption did not significantly affect measures of glycemic control. Summary estimates of weighted mean differences (WMD) and 95% confidence interval was 0.05 mmol/L (-0.11, 0.02) for fasting glucose concentration and 0.75 pmol/L (-1.82, 3.32) for fasting insulin concentrations. In conclusion, there was not a significant overall effect of beta-glucan intake on improvements of fasting glucose and insulin concentrations in hypercholesterolemic subjects. © 2015 Informa UK Ltd.

Li T.,Peoples Hospital of Gaozhou | Huang H.,Guangdong Medical College | Liao D.,Guangdong Medical College | Ling H.,Peoples Hospital of Gaozhou | And 2 more authors.
Molecular Genetics and Genomics | Year: 2015

Accumulating evidence has suggested that the human leucocyte antigen-G (HLA-G) 14 bp ins/del polymorphism might be related to cancer susceptibility. However, epidemiologic findings have been inconsistent. Therefore, we performed a meta-analysis of case–control study to derive a more precise estimation of this association. Electronic databases were searched to identify all eligible studies of HLA-G 14 bp ins/del polymorphism and cancer risk. Odds ratios (ORs) with 95 % confidence intervals (CIs) were calculated to evaluate the strength of the association in fixed-effects model or random-effects model according to heterogeneity. Publication bias, sensitivity analysis and subgroup analyses based on cancer type, ethnicity, source of controls and sample size were also performed. A total of 14 case–control studies, involving 2,757 cases and 3,972 controls, were included in the present meta-analysis. The pooled analysis showed that there is no significant relationship between the HLA-G 14 bp ins/del polymorphism and cancer susceptibility under the genetic models (for the allele model del vs. ins: OR  1.13, 95 % CI 1.00–1.27; for the homozygote comparison model del/del vs. ins/ins: OR 1.22, 95 % CI 0.95–1.56; for the dominant model del/del + ins/del vs. ins/ins: OR 1.15, 95 % CI 0.94–1.42; for recessive model del/del vs. ins/del + ins/ins: OR 1.13, 95 % CI 0.96–1.34; respectively). Subgroup analyses indicated significant association among breast cancer, population based control and the large sample size group in some genetic models. Our investigations demonstrate that genotypes for the HLA-G 14 bp ins/del polymorphism may be not associated with overall cancer risk. In a subgroup meta-analysis, however, HLA-G 14-bp ins/del polymorphism might contribute to breast cancer susceptibility. © 2015, Springer-Verlag Berlin Heidelberg.

Zhu X.,Peoples Hospital of Gaozhou | Sun X.,Peoples Hospital of Gaozhou | Wang M.,Peoples Hospital of Gaozhou | Zhang C.,Peoples Hospital of Gaozhou | And 4 more authors.
Nutrition, Metabolism and Cardiovascular Diseases | Year: 2015

Background & aims: A growing body of evidence suggests that beta-glucan derived from oats or barley can reduce cardiovascular disease risk through reductions in serum lipids. However, the effects of beta-glucan on lipid changes in hypercholesterolemic patient groups are inconsistent. The objective of this study was to identify and quantify the effect of beta-glucan, a marker of water-soluble fiber, on various lipid parameters and glucose level in hypercholesterolemic subjects. Methods and results: We performed a comprehensive literature search to identify the relevant randomized controlled trials (RCTs) that investigated the effects of beta-glucan consumption in hypercholesterolemic subjects. Mean differences (MDs) and 95% confidence intervals (CIs) were calculated for net changes in lipid concentrations by using fixed-effects or random-effects models according to heterogeneity. Publication bias, sensitivity analysis and subgroup analyses were also performed. Seventeen eligible RCTs with 916 subjects were included in the meta-analysis. The pooled result showed that beta-glucan consumption in hypercholesterolemic population significantly lowered the total cholesterol (TC) (MD, -0.26mmol/L; 95% CI, -0.33 to -0.18; P<0.00001) and low-density lipoprotein (LDL)-cholesterol concentration (MD, -0.21mmol/L; 95% CI, -0.27 to -0.14; P<0.00001). However, there were no significant differences in high-density lipoprotein (HDL)-cholesterol, triglycerides (TG) and glucose. No adverse effects were reported among the eligible trials. Conclusion: Our meta-analysis showed that beta-glucan consumption significantly decreased TC and LDL-cholesterol concentrations but did not affect TG, HDL-cholesterol, and glucose concentrations in hypercholesterolemic subjects. © 2015 Elsevier B.V..

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