Lyu Q.-G.,University of Sichuan |
Wang S.-Y.,Peoples Hospital of Ganzi Tibetan Autonomous Prefecture |
Zhang Y.-W.,University of Sichuan |
Wei S.-Y.,University of Sichuan |
And 3 more authors.
Journal of Sichuan University (Medical Science Edition) | Year: 2015
Objective To investigate the prevalence and risk factors of hyperuricemia (HUA) in Tibetan monks of Sichuan province. Methods 755 adult Tibetan monks (more than 18 years old) in Ganzi Tibetan Autonomous Prefecture of Sichuan Province were included in this study for health examination. Residents of Kangding City who received health examination were selected as controls. We measured the height, body mass, waist circumference, hip circumference, blood pressure and detected liver and renal function, serum lipid and blood routine exam. Then HUA prevalence in different genders and ages, and risk factors of HUA were analyzed. Results The serum uric acid (SUA) level of Tibetan monks was (318.03±107.70) μmol/L with the total HUA prevalence of 21.46%. The prevalence of male was higher than that of female (25.44% vs. 19.02%, P<0.05). The overall HUA prevalence of residents in Kangding City was 30.70%, which was higher than that of the monks (P<0.01). Prevalence of HUA in male monks was lower than the entire male population (25.44% vs. 41.65%) and male Tibetan ones (25.44% vs. 32.23%) in Kangding city. Among female population, however, we found that the HUA prevalence of monk (19.02%) was higher than that of overall female population (14.07%) and Tibetan residents (14.72%) in Kangding (P<0.05). Peak prevalence of HUA in Tibetan monks was between 30 and 40 years old. Gender, waist circumference, waist-to-height ratio (WHtR), fasting plasma glucose (FPG), serum creatinine (SCr), hemoglobin (Hb) levels and the consumption of meat were all independent risk factors for the occurrence of HUA in Tibetan monks according to Logistic regression analysis. Conclusion The prevalence of HUA in male Tibetan monks is lower than that of local urban Tibetan population, but the result in female monks is opposite. Gender, waist circumference, WHtR, FPG, SCr, Hb levels and the consumption of meat were all independent risk factors for HUA.
Lu C.-K.,Peoples Hospital Of Ganzi Tibetan Autonomous Prefecture
Chinese Journal of Tissue Engineering Research | Year: 2015
BACKGROUND: Isoflurane is gradually popularized in pediatric surgery due to its rapid onset, rapid recovery, and no savings, but its security needs to be further studied. OBJECTIVE: To explore the effect of isoflurane anesthesia on the proliferation and neuronal differentiation of neural stem cells in the dentate gyrus of neonatal rats. METHODS: Rats were randomly divided into isoflurane group and control group, respectively treated with isoflurane inhalation and air inhalation. 5-Bromodeoxyuridine ball glycosides (BrdU) was intraperitoneally injected before drug administration and after drug withdrawal, and 24 hours after secondary injection, the rats were executed to take brain tissues for detection of BrdU expression and brain neurogenic differentiation factor expression. RESULTS AND CONCLUSION: After cessation of anaesthesia processing for the detection of blood glucose and arterial blood gas, a mild rise in PaCO2 was found in the isoflurane group and pH showed a slight drop, but PaO2, BE, SaO2 and blood glucose levels were not changed. Compared with the control group, the isoflurane group did not appear with obvious hypoxia performances after isoflurane anesthesia, including cyanosis and respiratory depression. Rat neural stem cells of the dentate gyrus were mostly distributed in the gate area, and compared with the control group, the number of BrdU-positive cells was less in the isoflurane group (P < 0.05). A large number of new cells in the dentate gyrus expressed NeuroD, and the number of NeuroD+/BrdU+ cells in the gate area was significantly higher than that in the lower region of granule cells. Moreover, the number of NeuroD+/BrdU+ cells in the isoflurane group was significantly higher than that in the control group (P < 0.05). These findings suggest that isoflurane anesthesia can influence the proliferation and neuronal differentiation of neural stem cells in the dentate gyrus of neonatal rats, which inhibits cell proliferation and promotes neuronal differentiation.