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Cao D.-Q.,Peoples Hospital of Ganzhou City | Xiao C.-Z.,Peoples Hospital of Ganzhou City
World Chinese Journal of Digestology | Year: 2010

AIM: To investigate possible association between an interleukin-8 (IL-8) gene promoter polymorphism (-251A/T) and susceptibility to acute pancreatitis (AP). METHODS: Genomic DNA was isolated from venous blood leukocytes of 36 unrelated patients with mild acute pancreatitis (MAP), 83 unrelated patients with severe acute pancreatitis (SAP) and 236 unrelated healthy individuals (control group). The -251A/T polymorphism was genotyped by PCR-restriction fragment length polymorphisms (PCR-RFLP). Genotype and allele frequencies were analyzed using HaploView4.0 and SPSS11.5 software. RESULTS: There were significant differences in both allele and genotype frequencies of the -251A/T polymorphism between AP patients and healthy controls (TT: 40.34% vs 48.73%; AT: 47.06% vs 46.61%; AA: 12.61% vs 4.66%; T: 63.87% vs 72.03%; A: 36.13% vs 27.97%; all P < 0.01). The frequency of A allele was significantly higher in AP patients than in healthy controls (χ 2 = 4.962, P = 0.026, OR = 1.457, 95%CI 1.045-2.032). A significant difference was also noted in AA frequency between SAP patients and healthy controls (χ 2 = 8.244, P = 0.004, OR = 4.273, 95%CI 1.473-12.392). CONCLUSION: There is an association between the -251A/T polymorphism and susceptibility to AP. Individuals with A allele at the -251A/T locus are susceptible to AP.

Liu Z.-Y.,Peoples Hospital of Ganzhou City | Qian R.,Peoples Hospital of Ganzhou City | Xiao S.-L.,Peoples Hospital of Ganzhou City | Cai X.-J.,Peoples Hospital of Ganzhou City | And 3 more authors.
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2011

Background: The elderly commonly have their special physical characteristics of osteoporosis and poor tolerance to surgery. There are the higher complications and more mortality with femoral neck fracture in the elderly. Objective: To investigate the cemented bipolar hemiarthroplasty effect on osteoporotic femoral neck fractures in the elderly. Methods: Thirty-nine senior patients with osteoporotic femoral neck fractures admitted to the Department of Orthopaedics, People's Hospital of Ganzhou City from May 2006 to March 2009, were selected and all the patients received cemented bipolar hemiarthroplasty. Results And Conclusion: All the 39 cases were followed up for 10 to 34 months. The Harris hip function scores were 92.5±6.8 and 93.2±5.6 respectively at 6 and 12 months after cemented bipolar hemiarthroplasty, which were significantly higher than that (42.5±9.8) preoperatively (P < 0.01). Imaging examination showed that the location of all femoral prostheses was unchanged, no loosing or sinking. The final follow-up showed no aseptic loosening could be diagnosed with imaging findings or no requirement for renovation was found as well as non-limited pelvic osteolysis. The cemented bipolar hemiarthroplasty can reduce complications and lower mortality rates for the elderly with osteoporotic femoral neck fractures in a better way.

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