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Wang W.,Qingdao University | Li G.,Qingdao University | He X.,Peoples Hospital of Ganzhou | Gao J.,Maternal and Child Health | And 3 more authors.
Cellular Physiology and Biochemistry | Year: 2015

Background/Aims: Serum 25-hydroxyvitamin D [25(OH)D] levels proved to be associated with prognosis of patients with colorectal cancer or breast cancer, but its prognostic role in hematological malignancies was still unclear. A systematic review and meta-analysis was performed to comprehensively evaluate the association between serum 25(OH)D levels and prognosis of patients with hematological malignancies. Methods: We searched Pubmed, Embase, Web of Science, and Google Scholar for studies evaluating the association between serum 25(OH)D levels and prognosis of patients with hematological malignancies. The hazard ratios (HR) with 95% confidence intervals (95%CI) for overall survival (OS) or relapse-free survival (RFS) were pooled using meta-analysis. Results: Seven studies with a total of 2,643 patients with hematological cancer were finally included into the meta-analysis. Overall, compared with normal serum 25(OH)D levels, low serum 25(OH)D levels were significantly associated with both poorer OS (HR = 1.85, 95% CI 1.54-2.23, P <0.001) and poorer RFS (HR = 1.45, 95% CI 1.25 to 1.70, P <0.001) in hematological malignancies. Subgroup analysis further showed that low serum 25(OH)D levels were significantly associated with poorer OS and RFS in both lymphoma and leukemia. Conclusion: Low serum 25(OH)D levels are significantly associated with poorer prognosis in patients with hematological malignancies including lymphoma and leukemia. © 2015 S. Karger AG, Basel. Source


Zhang P.,Jiangxi University of Traditional Chinese Medicine | Liao Z.,Jiangxi University of Traditional Chinese Medicine | Liang X.,Jiangxi University of Traditional Chinese Medicine | Zhao G.,Jiangxi University of Traditional Chinese Medicine | And 2 more authors.
Zhongguo Zhongyao Zazhi | Year: 2011

A mathematical model of microwave drying kinetics based on Fick's second diffusion law was established and and the influence of microwave drying on ferulic acid (FA) and hydrosafflower yellow A (HSYA) in Shuxiong prescription was studied. The proposed model has been verified by using experimental data from microwave drying of Shuxiong prescription. By increasing the microwave output power (500-650 W) and the sample amount (15-60 g), the diversion rate of FA and HSYA changed. In order to determine the kinetic parameters, the drying data were fifed to various models based on the ratios of differences between the initial and final moisture contents and equilibrium moisture content versus drying time. The activation energy was calculated using an exponential expression based on Arrhenius equation. The relationship between the drying rate constant and effective moisture diffusivity was also estimated, and it showed linear. Source


Jiang W.,Central South University | Gao S.-G.,Central South University | Chen X.-G.,Peoples Hospital of Ganzhou | Xu X.-C.,Central South University | And 6 more authors.
Clinical Biochemistry | Year: 2012

Objectives: Vasoactive intestinal peptide (VIP) is a molecule shared by the neuroendocrine immune network and is considered to be a potential candidate for treatment of inflammatory and autoimmune diseases. Although some recent studies demonstrate that VIP has a protective role in animal RA models, its variant in different disease grade of OA remains uncertain. Design and methods: Fifty patients with primary knee OA and ten controls with severe trauma were enrolled. Synovial fluid and articular cartilage samples were collected from specimens of total knee arthroplasty (TKA) or knee above amputation. VIP levels in these samples were assessed by ELISA and immunohistochemistry. Kellgren-Lawrence criteria and Mankin score were taken to determine the disease severity. Results: Compared to the controls, OA patients have lower VIP concentration in synovial fluid (659.70 ± 112.79, 95%CI 579.01-740.38 vs 470.83 ± 156.40, 95%CI 426.38-515.28. pg/mL, P< 0.001) and articular cartilage (0.26 ± 0.02, 95%CI 0.24-0.28 vs 0.20 ± 0.04, 95%CI 0.18-0.21, P< 0.001). Subsequent analysis show that the VIP expression in synovial fluid is markedly correlated with its OD in articular cartilage (Pearson's r = 0.580, P< 0.001). Furthermore, the synovial fluid and articular cartilage levels of VIP both demonstrated to be negatively correlated with severity of disease (Spearman's ρ = 0.838, P< 0.001; Spearman's ρ = 0.814, P< 0.001). Conclusions: VIP in synovial fluid and articular cartilage is negatively associated with progressive joint damage in OA and is a potential indictor of disease severity. © 2012 The Canadian Society of Clinical Chemists. Source


Wang P.-P.,Maternal and Child Health Hospital of Weifang | He X.-Y.,Peoples Hospital of Ganzhou | Wang R.,Qingdao University | Wang Z.,Maternal and Child Health Hospital of Weifang | Wang Y.-G.,Qingdao University
Cellular Physiology and Biochemistry | Year: 2014

Background/Aims: Previous studies suggested that high leptin level might increase risk of endometrial cancer, but available data were conflicting and whether high leptin level was an independent risk factor of endometrial cancer was still unclear. Therefore, a meta-analysis was performed to assess whether high leptin level was an independent risk factor of endometrial cancer.Methods: PubMed, Web of Science, and Embase databases were searched for epidemiological studies published up to June 26, 2014. The pooled risk ratio (RR) with 95% confidence interval (95%CI) was used to assess the association between leptin level and risk of endometrial cancer.Results: Six studies with a total of 3136 individuals were finally included into the meta-analysis. Meta-analysis of total 6 studies showed that high leptin level was associated with increased risk of endometrial cancer (RR = 2.55, 95%CI 1.91-3.41, P < 0.001). After adjusting for confounding factors, high leptin level was also associated with increased risk of endometrial cancer (RR =1.59, 95%CI 1.27-1.98, P < 0.001). Sensitivity analysis proved the stability of the pooled estimates. The RR of endometrial cancer was 1.10 (95%CI, 1.03-1.18, P = 0.005) per 5 ng/mL increment in leptin levels. There was no obvious risk of publication bias (P Egger = 0.54).Conclusion: Our findings suggest that high leptin level is an independent risk factor of endometrial cancer. More prospective studies are needed to further confirm the association in the future. Copyright © 2014 S. Karger AG, Base. Source


Yi J.,Nanchang University | Yi J.,Yichun University | Shu X.,Nanchang University | Lv J.,Peoples Hospital of Ganzhou | And 3 more authors.
World Chinese Journal of Digestology | Year: 2014

AIM: To explore the relationship between the change of reactive oxygen species (ROS) and DNA damage caused by Helicobacter pylori (H. pylori) infection in gastric epithelial cells. METHODS: H. pylori ACTC43504 (CagA+, VacA+) infected GES-1 cells were used in this study. Live cell imaging system was used to observe the change of intracellular ROS, and a microplate reader was used to detect intracellular ROS level. Single cell gel electrophoresis comet assay was used to detect DNA damage. RESULTS: ROS level was proportional to H. pylori concentration, and the ROS level was the highest when the MOI of H. pylori was 300∶1. V arious concentrations of N-acety-L-cysteine (NAC) could significantly inhibit the generation of ROS caused by H. pylori infection. H. pylori could cause DNA damage. After NAC pretreatment, the values of tail length, comet length, tail moment, and Olive tail moment had a clear downward trend compared with the H. pylori group. CONCLUSION: H. pylori infection in GES-1 cells increases intracellular ROS level and results in DNA damage. Inhibition of the generation of ROS could reduce DNA damage. © 2014 Baishideng Publishing Group Inc. All rights reserved. Source

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