Peoples Hospital of Deqing County

Deqing, China

Peoples Hospital of Deqing County

Deqing, China
SEARCH FILTERS
Time filter
Source Type

Zhao Y.-Z.,Wenzhou University | Lin Q.,Wenzhou University | Wong H.L.,Temple University | Shen X.-T.,Peoples Hospital of Deqing County | And 8 more authors.
Journal of Controlled Release | Year: 2016

Malignant gliomas especially glioblastoma (GBM) are poorly responsive to the current treatments. Cilengitide (CGT) is a cyclic pentapeptide that demonstrated efficacy for GBM treatment by targeting the integrins avβ3 and avβ5 over-expressed on GBM cells. However, clinical translation of this therapy has been limited by issues including fast blood clearance, high kidney and liver uptake, poor blood-brain barrier (BBB) penetration, low tumor specificity and rapid washout from tumors. In this study, these issues were tackled in an integrated manner using a multi-stage strategy combining ultrasound-targeted microbubble destruction (UTMD) with CGT nanotherapy. CGT nanoparticles (CGT-NP) prepared using gelatin and Poloxamer 188-grafted heparin copolymer demonstrated significant apoptotic and cytotoxic effects in C6 GBM cells. Biodistribution study in a rat GBM model demonstrated buildup of high CGT level in tumors subjected to CGT-NP + UTMD combined therapy. The tumor CGT level in these animals was increased over 3-fold, tumor retention of CGT prolonged and renal clearance significantly reduced when compared with free CGT with or without UTMD. CGT-NP + UTMD treatment was further shown to extend the median survival period from less than 20 days in the control and about 30 days in free CGT group to about 80 days. This was achieved with low CGT dosing level (2 mg/kg twice weekly). In situ monitoring of GFAP, Ki67, caspase-3, Beclin-1, and LC-3 in the tumor samples together with TUNEL assay, transmission electron microscope imaging and Western blot assay all demonstrated high apoptotic and autophagy activities induced by the combined therapy. In conclusion, this study has provided extensive preclinical data supporting the use of this combined therapy to overcome the limitations of standard CGT treatment of gliomas. © 2016 Elsevier B.V. All rights reserved.


Hu X.-D.,Peoples Hospital of Deqing County | Bao Y.-Y.,First Affiliated Hospital | Zhou S.-H.,First Affiliated Hospital | Yao H.-T.,First Affiliated Hospital | And 3 more authors.
Journal of International Medical Research | Year: 2013

Objective: To investigate the expression of interleukin (IL) 17A in Chinese patients with chronic rhinosinusitis (CRS) and analyse its correlation with clinical parameters.Methods: Patients undergoing functional endoscopic sinus surgery and matched controls were included in this retrospective study. Clinical assessments (using a visual analogue scale of symptom severity, Johansson endoscopic score and Lund-Mackay computed tomography score) were performed preoperatively. Mucosal specimens were analysed for inflammatory infiltration and IL-17A expression, using immunohistochemistry. Results: In total, 40 patients undergoing functional endoscopic sinus surgery and 16 controls were included in the study. IL-17A levels were significantly higher in tissues from patients with CRS (with or without nasal polyps) than in control tissues. In CRS, IL-17A expression tended to be higher in tissues with infiltrating neutrophils than in those with infiltrating eosinophils, but this difference was not significant. IL-17A expression in CRS was positively correlated with symptom severity, endoscopic findings and radiological appearance. Conclusions: Expression of IL-17A was higher in Chinese patients with CRS than in controls, and was associated with infiltrating inflammatory cells, symptom severity, endoscopic findings and radiological appearance. These findings suggest that IL-17A may play a role in CRS pathogenesis and remodelling of nasal polyps. © The Author(s) 2013.


Chen Q.-Q.,Huzhou Teachers College | Ji X.-X.,Peoples Hospital of Deqing County | Zhou X.,Huzhou Teachers College | Shi Q.-L.,Huzhou Teachers College | And 3 more authors.
Wspolczesna Onkologia | Year: 2015

Aim of the study: This study aimed to compare the efficacy and toxicity of docetaxel combined with cisplatin (DP) and gemcitabine combined with cisplatin (GP) in postoperative chemotherapy after surgery of non-small cell lung cancer (NSCLC). Material and methods: A total of 92 patients diagnosed with NSCLC after surgery were enrolled, and they were treated with DP (DP group) and GP (GP group). The efficacy and toxicity of the medications were then compared. Results: Approximately 92.4% (85 out of 92) of the patients received chemotherapy for more than three weeks. In the DP and GP groups, the incidence rates of grade III-IV thrombocytopenia were 24.4% and 6.38%, respectively, whereas the incidence rates of alopecia were 88.9% and 25.5%, respectively. The difference between the two groups was statistically significant (p < 0.05). Disease-free survival rates in DP group in one and two years were 76.5% and 50.47%, respectively, whereas in the GP group they were 77.8% and 49.52%, respectively. No significant difference was observed between the two groups (p > 0.05). Conclusions: These results showed similar disease-free survival rates of DP and GP therapies in one and two years after surgery for NSCLC. However, the DP group exhibited higher incidence rates of grade III-IV thrombocytopenia and alopecia than the GP group. Therefore, we should select a specific treatment for each patient according to individual differences.


Ye F.,Zhejiang University | Tang C.,Peoples Hospital of Deqing County | Wang D.,Zhejiang University | Zheng S.,Zhejiang University
Presentations from the 9th Annual Electric Utilities Environmental Conference | Year: 2015

Background: Transsphincteric fistulotomy is associated with a variable degree of fecal incontinence. Ligation of the intersphincteric fistula tract (LIFT), a novel surgical procedure with the advantage of avoiding anal incontinence, has a variable success rate of 57-94 %. We evaluated a modified approach from it. Our aim was to review the preliminary results using this technique for high transsphincteric fistula. Methods: A retrospective analysis of a consecutive series of high transsphincteric fistula patients who underwent the modified LIFT (mLIFT) procedure was performed. The surgical technique involved making a lateral incision from external opening to intersphincteric groove; ligation of the fistula tract within the intersphincteric space; and complete excision of the distal part of fistula from external opening to external sphincter. The patients were followed for healing time, recurrence, fecal continence disturbance, and any other associated morbidity. Results: Over a 2-year period, 43 patients with high transsphincteric anal fistula were treated by mLIFT technique. Four patients were lost at follow-up. In a mean follow-up of 15 months, 34/39 (87.2 %) of the patients achieved primary or secondary healing. Five patients had persistent symptoms and required further surgical treatment. The second procedures were successful, and finally resulting in an overall healing rate of 100 %. The Wexner incontinence scale was 0 (0-20) both before and at 6 months after the procedure. Conclusions: The mLIFT procedure for high transsphincteric fistula appeared to effectively preserve continence and achieved a comparable success rate to other sphincter-preserving techniques. © 2014 Société Internationale de Chirurgie.


Hu X.-D.,Zhejiang University | Hu X.-D.,Peoples Hospital Of Deqing County | Wu T.-T.,Zhejiang University | Zhou S.-H.,Zhejiang University
International Journal of Clinical and Experimental Medicine | Year: 2015

Squamous cell carcinoma of the middle ear (SCCME) accounts for 1.5% of malignant tumors in the ear. Because of the low incidence and infrequent reports of SCCME, the extent of concordance between CT and MRI results, surgical findings, and pathology reports are not well-characterized. In the present study, we reported CT and MRI images in three SCCME cases, and assessed the relationship between these results and those of surgery and the pathological report. Middle ear carcinoma is frequently misdiagnosed before surgery. In three cases of middle ear carcinoma, CT revealed the following: 1) soft tissue density lesions centered around the middle tympanum, exhibiting increased density, with external auditory canal involvement; 2) damage and absorption in the mastoid area, ossicles, and facial nerve canal, characterized by an irregular, worm-eaten appearance, without sclerotic margins; and 3) lesion infiltration of the surrounding bony substance of the middle ear, temporal squama, temporomandibular joint, anterior wall of the sigmoid sinus, and horizontal segment of the canalis caroticus (in one case lesion invasion into the intracranial cavity occurred through sigmoid sinus walls; no signs of intracranial invasion were seen in the other two cases). Enhanced lesion imaging revealed partial heterogeneous enhancement. In one patient MRI revealed a defined mass in the mastoid area of the middle ear. Signals in the lesion were partially heterogeneous and similar to brain tissue in T1- and T2-weighted images. The lesion was significantly enhanced following application of a contrast agent, while the adjacent meninges also exhibited linear enhancement. No abnormal signals were detected in the brain parenchyma. The destruction of adjacent bone plates was poorly defined. The CT and MRI results were consistent with the invasive features of middle ear cancer documented in the post-surgery pathology report. © 2015, E-Century Publishing Corporation. All Rights Reserved.


PubMed | Peoples Hospital of Deqing County, Wenzhou University and Temple University
Type: | Journal: Journal of controlled release : official journal of the Controlled Release Society | Year: 2016

Malignant gliomas especially glioblastoma (GBM) are poorly responsive to the current treatments. Cilengitide (CGT) is a cyclic pentapeptide that demonstrated efficacy for GBM treatment by targeting the integrins av3 and av5 over-expressed on GBM cells. However, clinical translation of this therapy has been limited by issues including fast blood clearance, high kidney and liver uptake, poor blood-brain barrier (BBB) penetration, low tumor specificity and rapid washout from tumors. In this study, these issues were tackled in an integrated manner using a multi-stage strategy combining ultrasound-targeted microbubble destruction (UTMD) with CGT nanotherapy. CGT nanoparticles (CGT-NP) prepared using gelatin and Poloxamer 188-grafted heparin copolymer demonstrated significant apoptotic and cytotoxic effects in C6 GBM cells. Biodistribution study in a rat GBM model demonstrated buildup of high CGT level in tumors subjected to CGT-NP+UTMD combined therapy. The tumor CGT level in these animals was increased over 3-fold, tumor retention of CGT prolonged and renal clearance significantly reduced when compared with free CGT with or without UTMD. CGT-NP+UTMD treatment was further shown to extend the median survival period from less than 20days in the control and about 30days in free CGT group to about 80days. This was achieved with low CGT dosing level (2mg/kg twice weekly). In situ monitoring of GFAP, Ki67, caspase-3, Beclin-1, and LC-3 in the tumor samples together with TUNEL assay, transmission electron microscope imaging and Western blot assay all demonstrated high apoptotic and autophagy activities induced by the combined therapy. In conclusion, this study has provided extensive preclinical data supporting the use of this combined therapy to overcome the limitations of standard CGT treatment of gliomas.


PubMed | Huzhou Teachers College and Peoples Hospital of Deqing County
Type: Journal Article | Journal: Pakistan journal of medical sciences | Year: 2015

This study aimed to compare the efficacy and toxicity of docetaxel combined with cisplatin (DP) and gemcitabine combined with cisplatin (GP) in postoperative chemotherapy after surgery of non-small cell lung cancer (NSCLC).A total of 92 patients diagnosed with NSCLC after surgery were enrolled, and they were treated with DP (DP group) and GP (GP group). The efficacy and toxicity of the medications were then compared.Approximately 92.4% (85 out of 92) of the patients received chemotherapy for more than three weeks. In DP and GP groups, the incidence rates of grade III-IV thrombocytopenia were 24.4% and 6.38%, respectively, whereas the incidence rates of alopecia were 88.9% and 25.5%, respectively. The difference between the two groups was statistically significant (P < 0.05). Disease-free survival rates in DP group in one and two years were 76.5% and 50.47%, respectively, whereas in GP group were 77.8% and 49.52%, respectively. No significant difference was observed between the two groups (P > 0.05).These results showed similar disease-free survival rates of DP and GP therapies in one and two years after surgery for NSCLC. However, DP group exhibited higher incidence of grade III-IV thrombocytopenia and alopecia than GP group. Therefore, we should select a specific treatment for each patient according to individual differences.


PubMed | Huzhou Teachers College and Peoples Hospital of Deqing County
Type: Journal Article | Journal: Contemporary oncology (Poznan, Poland) | Year: 2015

This study aimed to compare the efficacy and toxicity of docetaxel combined with cisplatin (DP) and gemcitabine combined with cisplatin (GP) in postoperative chemotherapy after surgery of non-small cell lung cancer (NSCLC).A total of 92 patients diagnosed with NSCLC after surgery were enrolled, and they were treated with DP (DP group) and GP (GP group). The efficacy and toxicity of the medications were then compared.Approximately 92.4% (85 out of 92) of the patients received chemotherapy for more than three weeks. In the DP and GP groups, the incidence rates of grade III-IV thrombocytopenia were 24.4% and 6.38%, respectively, whereas the incidence rates of alopecia were 88.9% and 25.5%, respectively. The difference between the two groups was statistically significant (p < 0.05). Disease-free survival rates in DP group in one and two years were 76.5% and 50.47%, respectively, whereas in the GP group they were 77.8% and 49.52%, respectively. No significant difference was observed between the two groups (p > 0.05).These results showed similar disease-free survival rates of DP and GP therapies in one and two years after surgery for NSCLC. However, the DP group exhibited higher incidence rates of grade III-IV thrombocytopenia and alopecia than the GP group. Therefore, we should select a specific treatment for each patient according to individual differences.


Chen Q.,Huzhou Teachers College | Ji X.,Peoples Hospital Of Deqing County | Zhou X.,Huzhou Teachers College | Shi Q.,Huzhou Teachers College | And 2 more authors.
Pakistan Journal of Medical Sciences | Year: 2015

Objective: This study aimed to compare the efficacy and toxicity of docetaxel combined with cisplatin (DP) and gemcitabine combined with cisplatin (GP) in postoperative chemotherapy after surgery of nonsmall cell lung cancer (NSCLC). Methods: A total of 92 patients diagnosed with NSCLC after surgery were enrolled, and they were treated with DP (DP group) and GP (GP group). The efficacy and toxicity of the medications were then compared. Results: Approximately 92.4% (85 out of 92) of the patients received chemotherapy for more than three weeks. In DP and GP groups, the incidence rates of grade III-IV thrombocytopenia were 24.4% and 6.38%, respectively, whereas the incidence rates of alopecia were 88.9% and 25.5%, respectively. The difference between the two groups was statistically significant (P < 0.05). Disease-free survival rates in DP group in one and two years were 76.5% and 50.47%, respectively, whereas in GP group were 77.8% and 49.52%, respectively. No significant difference was observed between the two groups (P > 0.05). Conclusion: These results showed similar disease-free survival rates of DP and GP therapies in one and two years after surgery for NSCLC. However, DP group exhibited higher incidence of grade III-IV thrombocytopenia and alopecia than GP group. Therefore, we should select a specific treatment for each patient according to individual differences. © 2011-12, All Rights Reserved. e Journal System.


PubMed | Peoples Hospital of Deqing County
Type: Journal Article | Journal: The Journal of international medical research | Year: 2013

To investigate the expression of interleukin (IL) 17A in Chinese patients with chronic rhinosinusitis (CRS) and analyse its correlation with clinical parameters.Patients undergoing functional endoscopic sinus surgery and matched controls were included in this retrospective study. Clinical assessments (using a visual analogue scale of symptom severity, Johansson endoscopic score and Lund-Mackay computed tomography score) were performed preoperatively. Mucosal specimens were analysed for inflammatory infiltration and IL-17A expression, using immunohistochemistry.In total, 40 patients undergoing functional endoscopic sinus surgery and 16 controls were included in the study. IL-17A levels were significantly higher in tissues from patients with CRS (with or without nasal polyps) than in control tissues. In CRS, IL-17A expression tended to be higher in tissues with infiltrating neutrophils than in those with infiltrating eosinophils, but this difference was not significant. IL-17A expression in CRS was positively correlated with symptom severity, endoscopic findings and radiological appearance.Expression of IL-17A was higher in Chinese patients with CRS than in controls, and was associated with infiltrating inflammatory cells, symptom severity, endoscopic findings and radiological appearance. These findings suggest that IL-17A may play a role in CRS pathogenesis and remodelling of nasal polyps.

Loading Peoples Hospital of Deqing County collaborators
Loading Peoples Hospital of Deqing County collaborators