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Ye F.,Zhejiang University | Tang C.,Peoples Hospital of Deqing County | Wang D.,Zhejiang University | Zheng S.,Zhejiang University
Presentations from the 9th Annual Electric Utilities Environmental Conference | Year: 2015

Background: Transsphincteric fistulotomy is associated with a variable degree of fecal incontinence. Ligation of the intersphincteric fistula tract (LIFT), a novel surgical procedure with the advantage of avoiding anal incontinence, has a variable success rate of 57-94 %. We evaluated a modified approach from it. Our aim was to review the preliminary results using this technique for high transsphincteric fistula. Methods: A retrospective analysis of a consecutive series of high transsphincteric fistula patients who underwent the modified LIFT (mLIFT) procedure was performed. The surgical technique involved making a lateral incision from external opening to intersphincteric groove; ligation of the fistula tract within the intersphincteric space; and complete excision of the distal part of fistula from external opening to external sphincter. The patients were followed for healing time, recurrence, fecal continence disturbance, and any other associated morbidity. Results: Over a 2-year period, 43 patients with high transsphincteric anal fistula were treated by mLIFT technique. Four patients were lost at follow-up. In a mean follow-up of 15 months, 34/39 (87.2 %) of the patients achieved primary or secondary healing. Five patients had persistent symptoms and required further surgical treatment. The second procedures were successful, and finally resulting in an overall healing rate of 100 %. The Wexner incontinence scale was 0 (0-20) both before and at 6 months after the procedure. Conclusions: The mLIFT procedure for high transsphincteric fistula appeared to effectively preserve continence and achieved a comparable success rate to other sphincter-preserving techniques. © 2014 Société Internationale de Chirurgie.


Zhang M.,Wenzhou University | Yu W.-Z.,Wenzhou University | Shen X.-T.,Peoples Hospital of Deqing County | Xiang Q.,Jinan University | And 7 more authors.
Cardiovascular Drugs and Therapy | Year: 2016

This study aims to investigate the preclinical performance and mechanism of a novel strategy of aFGF-loaded heparin-modified microbubbles (aFGF-HMB) combined with ultrasound-targeted microbubble destruction (UTMD) technique for diabetic cardiomyopathy (DCM) prevention. Type 1 diabetic rats were induced by streptozotocin. Twelve weeks after intervention, indexes from transthoracic echocardiography and cardiac catheterization showed that the left ventricular function in the aFGF-HMB/UTMD group was significantly improved compared with diabetes control (DM). From Picrosirius Red staining and TUNEL staining, the aFGF-HMB/UTMD group showed significant difference from the other groups. The cardiac collagen volume fraction (CVF) and myocardial cell apoptosis index (AI) in aFGF-HMB/UTMD group decreased to 7.2 % and 7.11 % respectively, compared with the DM group (CVF = 24.5 % and AI =20.3 % respectively). The results of myocardial microvascular density (MCD) also proved the strongest inhibition of aFGF-HMB/UTMD group on DCM progress. CD31 staining of aFGF-HMB/UTMD group reached 22 n/hrp, much higher than that of DM group (9 n/hrp). These results confirmed that the abnormalities including left ventricular dysfunction, myocardial fibrosis, cardiomyocytes apoptosis and microvascular rarefaction could be suppressed by twice weekly aFGF treatments for 12 consecutive weeks (free aFGF or aFGF-HMB+/−UTMD), with the strongest improvements observed in the aFGF-HMB/UTMD group (P < 0.05 vs free aFGF or aFGF-HMB). Western blot analyses of heart tissue further revealed the highest aFGF, anti-apoptosis protein (Bcl-2), VEGF-C, pAkt, pFoxo-3a levels and strongest reduction in pro-apoptosis proteins (Bax) level in aFGF-HMB/UTMD group. Overall, aFGF-HMB combined with UTMD technique might be developed as an effective strategy to prevent DCM in future clinical therapy. © 2016, Springer Science+Business Media New York.


Chen Q.,Huzhou Teachers College | Ji X.,Peoples Hospital of Deqing County | Zhou X.,Huzhou Teachers College | Shi Q.,Huzhou Teachers College | And 2 more authors.
Pakistan Journal of Medical Sciences | Year: 2015

Objective: This study aimed to compare the efficacy and toxicity of docetaxel combined with cisplatin (DP) and gemcitabine combined with cisplatin (GP) in postoperative chemotherapy after surgery of nonsmall cell lung cancer (NSCLC). Methods: A total of 92 patients diagnosed with NSCLC after surgery were enrolled, and they were treated with DP (DP group) and GP (GP group). The efficacy and toxicity of the medications were then compared. Results: Approximately 92.4% (85 out of 92) of the patients received chemotherapy for more than three weeks. In DP and GP groups, the incidence rates of grade III-IV thrombocytopenia were 24.4% and 6.38%, respectively, whereas the incidence rates of alopecia were 88.9% and 25.5%, respectively. The difference between the two groups was statistically significant (P < 0.05). Disease-free survival rates in DP group in one and two years were 76.5% and 50.47%, respectively, whereas in GP group were 77.8% and 49.52%, respectively. No significant difference was observed between the two groups (P > 0.05). Conclusion: These results showed similar disease-free survival rates of DP and GP therapies in one and two years after surgery for NSCLC. However, DP group exhibited higher incidence of grade III-IV thrombocytopenia and alopecia than GP group. Therefore, we should select a specific treatment for each patient according to individual differences. © 2011-12, All Rights Reserved. e Journal System.


Chen Q.-Q.,Huzhou Teachers College | Ji X.-X.,Peoples Hospital of Deqing County | Zhou X.,Huzhou Teachers College | Shi Q.-L.,Huzhou Teachers College | And 3 more authors.
Wspolczesna Onkologia | Year: 2015

Aim of the study: This study aimed to compare the efficacy and toxicity of docetaxel combined with cisplatin (DP) and gemcitabine combined with cisplatin (GP) in postoperative chemotherapy after surgery of non-small cell lung cancer (NSCLC). Material and methods: A total of 92 patients diagnosed with NSCLC after surgery were enrolled, and they were treated with DP (DP group) and GP (GP group). The efficacy and toxicity of the medications were then compared. Results: Approximately 92.4% (85 out of 92) of the patients received chemotherapy for more than three weeks. In the DP and GP groups, the incidence rates of grade III-IV thrombocytopenia were 24.4% and 6.38%, respectively, whereas the incidence rates of alopecia were 88.9% and 25.5%, respectively. The difference between the two groups was statistically significant (p < 0.05). Disease-free survival rates in DP group in one and two years were 76.5% and 50.47%, respectively, whereas in the GP group they were 77.8% and 49.52%, respectively. No significant difference was observed between the two groups (p > 0.05). Conclusions: These results showed similar disease-free survival rates of DP and GP therapies in one and two years after surgery for NSCLC. However, the DP group exhibited higher incidence rates of grade III-IV thrombocytopenia and alopecia than the GP group. Therefore, we should select a specific treatment for each patient according to individual differences.


Hu X.-D.,Peoples Hospital of Deqing County | Bao Y.-Y.,First Affiliated Hospital | Zhou S.-H.,First Affiliated Hospital | Yao H.-T.,First Affiliated Hospital | And 3 more authors.
Journal of International Medical Research | Year: 2013

Objective: To investigate the expression of interleukin (IL) 17A in Chinese patients with chronic rhinosinusitis (CRS) and analyse its correlation with clinical parameters.Methods: Patients undergoing functional endoscopic sinus surgery and matched controls were included in this retrospective study. Clinical assessments (using a visual analogue scale of symptom severity, Johansson endoscopic score and Lund-Mackay computed tomography score) were performed preoperatively. Mucosal specimens were analysed for inflammatory infiltration and IL-17A expression, using immunohistochemistry. Results: In total, 40 patients undergoing functional endoscopic sinus surgery and 16 controls were included in the study. IL-17A levels were significantly higher in tissues from patients with CRS (with or without nasal polyps) than in control tissues. In CRS, IL-17A expression tended to be higher in tissues with infiltrating neutrophils than in those with infiltrating eosinophils, but this difference was not significant. IL-17A expression in CRS was positively correlated with symptom severity, endoscopic findings and radiological appearance. Conclusions: Expression of IL-17A was higher in Chinese patients with CRS than in controls, and was associated with infiltrating inflammatory cells, symptom severity, endoscopic findings and radiological appearance. These findings suggest that IL-17A may play a role in CRS pathogenesis and remodelling of nasal polyps. © The Author(s) 2013.

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