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Cai L.-P.,Peoples Hospital of Beihai | Zhou L.-J.,The First Peoples Hospital of Yulin | Lu S.-Y.,Liuzhou Workers Hospital | Liang Y.-E.,The first peoples hospital of Nanning | And 3 more authors.
Molecular Biology Reports | Year: 2014

Interleukin-18(IL-18) plays a potential pathological role in rheumatoid arthritis (RA). The conclusions of the published reports on the relationship between single-nucleotide polymorphisms −607C/A (rs1946518) and −137G/C (rs187238) located in the IL-18 gene promoter and RA risk remain controversial. This meta-analysis was performed to evaluate the association between IL-18 gene promoter (−607A/C and −137C/G) polymorphisms and RA using (1) allele, (2) codominant, (3) dominant, and (4) recessive models. Literature search was conducted up to January, 2013, in PubMed, EMBASE, Spring-link, Web of Science, Wanfang (Chinese) and China National Knowledge Infrastructure (CNKI). A total of 10 studies from eight articles involving 2,662 cases and 2,168 controls for −607A/C polymorphism and 9 studies from six articles involving 1,331 cases and 1,468 controls for −137C/G polymorphism were considered in the meta-analysis. For the relationship of IL-18 −607A/C polymorphism with RA risk, significant association was observed in allele model (OR = 0.778, 95 % CI = 0.633–0.955) and dominant model (OR = 0.618, 95 % CI = 0.466–0.819). However, no significant association could be observed between −137C/G polymorphism and RA risk under all genetic models (allele model: OR = 0.940, 95 % CI = 0.777–1.138; codominant model: OR = 1.079, 95 % CI = 0.574–2.029; dominant model: OR = 0.913, 95 % CI = 0.779–1.069; recessive model: OR = 1.133, 95 % CI = 0.586–2.190). In the subgroup analysis by ethnicity, significant result was also found in Asian populations but not found in Caucasian populations for the relationship of IL-18 −607A/C polymorphism with RA risk; while no obvious association was found between IL-18 −137C/G polymorphism and RA risk. This meta-analysis indicates that IL-18 −607A/C polymorphism in promoter region may be associated with RA risk. © 2014, Springer Science+Business Media Dordrecht. Source


Tang B.,Guilin Medical University | Lv J.,Peoples Hospital of Beihai | Li Y.,Guilin Medical University | Yuan S.,Guilin Medical University | And 2 more authors.
Medicine (United States) | Year: 2015

The objective of this study was to assess the relationship between female hormone and menstrual factors and pancreatic cancer (PC) through a meta-analysis of observational studies. We undertook a systematic literature search up to July 10, 2014 in PubMed and EMBASE databases. Combined relative risks (RRs) were estimated by random-effects models. Subgroup analysis was performed by study design, source of control, and geographic regions. Sensitivity analyses and publication bias were utilized to evaluate the robustness of our results. A total of 27 case-control and cohort studies were retrieved for this meta-analysis. No significant associations were observed between the risk of PC and age at menarche (RR=0.94, 95% confidence interval [CI] 0.83-1.07), age at menopause (RR=0.98, 95% CI 0.85-1.13), hysterectomy (RR=0.97, 95% CI 0.84-1.11), oophorectomy (RR=1.02, 95% CI 0.82-1.26), hormone replacement therapy (RR=0.97, 95% CI 0.87-1.08), and oral contraceptives (RR=1.09, 95% CI 0.96-1.23). This meta-analysis of observational studies does not support the hypothesis that exogenous hormone use and menstrual factors are associated with PC. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. Source


Zhong H.,Peoples Hospital of Beihai | Zhou R.,Peoples Hospital of GuiPing | Feng Y.,Peoples Hospital of Beihai | Zheng G.-X.,Peoples Hospital of Beihai | And 6 more authors.
Journal of Receptors and Signal Transduction | Year: 2014

Relationship between vitamin D receptor (VDR) gene polymorphism and the risk of lung cancer from the published reports are still conflicting. This study was conducted to evaluate the relationship between VDR TaqI (rs731236), BsmI (rs1544410) and ApaI (rs7975232) gene polymorphism and the risk of lung cancer using meta-analysis method. The association studies were identified from PubMed and Cochrane Library on 1 December 2013, and eligible investigations were included and synthesized using meta-analysis method. Six reports were recruited into this meta-analysis for the association of VDR gene polymorphism with lung cancer susceptibility. In the meta-analysis for ApaI gene polymorphism, AA genotype was associated with the risk of lung cancer in Asians. In the meta-analysis for BsmI gene polymorphism, B allele, BB genotype and bb genotype were associated with lung cancer in Asians, and B allele bb genotype were associated with lung cancer risk in overall populations; furthermore, bb genotype was associated with lung cancer risk in Caucasians. In the meta-analysis for TaqI gene polymorphism, t allele and TT genotype were associated with lung cancer in overall populations and in Caucasians. In conclusion, B allele bb genotype t allele and TT genotype were associated with lung cancer risk in overall populations. AA genotype, B allele, BB genotype and bb genotype were associated with the risk of lung cancer in Asians. Furthermore, bb genotype t allele and TT genotype was associated with lung cancer risk in Caucasians. However, more studies should be conducted to confirm it. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted. Source


Zhong H.,Peoples Hospital of Beihai | Feng Y.,Peoples Hospital of Beihai | Zheng G.-X.,Peoples Hospital of Beihai | Liang Y.,Peoples Hospital of Beihai | And 3 more authors.
Cancer Biomarkers | Year: 2013

Background: Results of the published reports on the relationship between glutathione S-transferase P1 (GSTP1) gene polymorphism and the adenocarcinomas of lung cancer are still debated. Objective: This meta-analysis was performed to evaluate the association between GSTP1 A/G gene polymorphism and the risk of adenocarcinomas of lung cancer. Methods: The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method. Results: 16 reports were included into this meta-analysis for the association of GSTP1 A/G gene polymorphism and the risk of adenocarcinomas of lung cancer. The G allele and GG genotype were not associated with the susceptibility of risk of adenocarcinomas. Furthermore, in the sensitivity analysis, the Results were similar with those from the non-sensitivity analysis. Conclusions: GSTP1 G allele or GG genotype is not a biomarker to be associated with the susceptibility of adenocarcinomas of lung cancer. © 2013-IOS Press and the authors. All rights reserved. Source


Qin W.-H.,Peoples Hospital of Beihai | Wang H.-X.,Peoples Hospital of Beihai | Qiu J.-L.,Peoples Hospital of Beihai | Huang X.-B.,Peoples Hospital of Beihai | And 3 more authors.
Journal of Receptors and Signal Transduction | Year: 2014

Association between vitamin D receptor (VDR) BsmI (rs1544410) gene polymorphism and the risk of type 1 diabetes mellitus (T1DM) from the published reports are still conflicting. This study was conducted to evaluate the relationship between VDR BsmI gene polymorphism and the risk of T1DM using meta-analysis method. The association studies were identified from PubMed, and Cochrane Library on 1 December 2013, and eligible investigations were included and synthesized using meta-analysis method. Twenty-three reports were recruited into this meta-analysis for the association of VDR BsmI gene polymorphism with T1DM susceptibility. In overall populations, bb genotype was associated with T1DM, but the B allele and BB genotype were not. In Asians and Latino population, B allele and bb genotype were associated with TIDM risk, but BB genotype was not. In Caucasians, VDR BsmI gene polymorphism was not associated with the T1DM risk. In Africans, B allele and BB genotype were associated with T1DM risk, but the bb genotype was not. However, the sample size for Latino population and Africans was small. In conclusion, VDR BsmI B allele, bb genotype was associated with T1DM risk in Asians, and bb genotype was associated with T1DM risk in overall populations. However, more studies should be conducted to confirm it. © 2014 Informa Healthcare USA, Inc. Source

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