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Zheng X.-X.,Peoples Hospital | Jiang Y.-R.,Peoples Hospital | Jiang Y.-R.,Peking University
Graefe's Archive for Clinical and Experimental Ophthalmology | Year: 2014

Background: In Coats' disease, the most recent development in the treatment has been the intravitreal injection of anti-VEGF agents. The purpose of this article was to evaluate the effect of intravitreal bevacizumab as the initial treatment for Coats' disease in children and adults. Methods: The study included 14 pediatric patients and five adult patients with Coats' disease. They were treated with intravitreal bevacizumab (1.25 mg/0.05 ml) as the initial treatment, combined with or without other treatments. The analyses included the evaluation of basic clinical conditions. Results: In the pediatric group, after a mean of 9.1 months of follow-up, the differences in visual acuity were significant for the comparisons between the baseline examination and the follow-up examinations carried out at weeks 6, 12, and 24 after the baseline (P = 0.006, P = 0.004, P = 0.005 respectively). Vitreoretinal fibrosis was observed in three patients (n = 3, 21.4 %), among whom two showed fibrosis before treatment. All of the pediatric patients showed a resolution of fluid and exudation, and regression of the telangiectasia. In the adult group, after a mean of 10.6 months of follow-up, the differences in visual acuity were not statistically significant (P > 0.05) between the baseline and follow-up examinations. Vitreoretinal fibrosis (n = 2, 40 %) was observed in two patients who both showed fibrosis before treatment. All of the adult patients showed a resolution of fluid and exudation, and regression of the telangiectasia. The differences in the change of BCVA between children and adults were not significant (P > 0.05) during the follow-up examinations. Conclusion: The intravitreal injection of bevacizumab as the initial treatment is associated with a measurable gain in visual acuity in patients with Coats' disease. Resolution of the subretinal fluid and exudation, and regression of the telangiectasia were observed in both pediatric and adult patients. Vitreoretinal fibrosis may be one of the natural courses of Coats' disease, and it remains uncertain whether bevacizumab accelerates the fibrosis phenomenon. © 2013 Springer-Verlag Berlin Heidelberg.


Cang S.,Peoples Hospital | Mukhi N.,New York Medical College | Wang K.,New York Medical College | Liu D.,New York Medical College
Journal of Hematology and Oncology | Year: 2012

Rituximab (RTX), a monoclonal antibody (mAb) against CD20, has been widely used for lymphoma therapy. RTX in combination with cyclophosphamide /doxorubicin /vincristine /prednisone (R-CHOP) remains the standard frontline regimen for diffuse large B-cell lymphoma. However, suboptimal response and /or resistance to rituximab have remained a challenge in the therapy of B-cell non-Hodgkins lymphoma (NHL). Novel agents are under active clinical trials. This review will summarize the latest development in new mAbs against CD20, which include second-generation mAbs, ofatumumab, veltuzumab (IMMU-106), ocrelizumab (PRO70769), and third-generation mAbs, AME-133v (ocaratuzumab), PRO131921 and GA101 (obinutumumab). © 2012 Cang et al.; licensee BioMed Central Ltd.


Cang S.,Peoples Hospital | Cang S.,New York Medical College | Lu Q.,Xiamen Zhongshan Hospital | Ma Y.,New York Medical College | Liu D.,New York Medical College
Current Cancer Drug Targets | Year: 2010

DNA methylation and histone acetylation are two most studied epigenetic markers. Aberrant methylation of gene promoter regions and histone tail lysine residue modification through acetylation and methylation play a key role in malignant disorders. Two DNA methyltransferase inhibitors, azacitidine and decitabine, have been licensed for clinical therapy for patients with myelodysplastic syndrome. New hypomethylating agents, zebularine and isothiocyanates, are in various stages of development for cancer therapy. In this review we summarize recent clinical developments on novel hypomethylating agents and new regimens from clinical trials for epigenetic therapy of cancer. © 2010 Bentham Science Publishers Ltd.


Tao Y.,Peoples Hospital | Tong X.,Tsinghua University | Zhang Y.,Peoples Hospital | Lai J.,Tsinghua University | And 3 more authors.
Acta Biomaterialia | Year: 2013

Currently there is no material that can be used as a long-term vitreous substitute, and this remains an unmet clinical need in ophthalmology. In this study, we developed an injectable, in situ chemically crosslinked hydrogel system and evaluated it in a rabbit model. The system consisted of two components, both based on multi-functional poly(ethylene glycol) (PEG) but with complementarily reactive end groups of thiol and active vinyl groups, respectively. The two components are mixed and injected as a solution mixture, react in vivo via the Michael addition route and form a chemically crosslinked hydrogel in situ. The linkages between the end groups and the backbone PEG chains are specially designed to ensure that the final network structure is hydrolysis-resistant. In the rabbit study and with an optimized operation protocol, we demonstrated that the hydrogel indeed formed in situ after injection, and remained transparent and stable during the study period of 9 months without significant adverse reactions. In addition, the hydrogel formed in situ showed rheological properties very similar to the natural vitreous. Therefore, our study demonstrated that this in situ chemically crosslinked PEG gel system is suitable as a potential long-term vitreous substitute. Crown Copyright © 2012 Published by Elsevier Ltd. on behalf of Acta Materialia Inc. All rights reserved.


Zhang T.,Peoples Hospital | Jia Y.,Peoples Hospital
Medical Science Monitor | Year: 2014

Background: Some studies have evaluated the association between the Ubiquilin 1 (UBQLN1) gene UBQ-8i polymorphism and Alzheimer’s disease (AD). However, the results remain uncertain. We carried out a meta-analysis to derive a more comprehensive estimation of this association.Material/Methods: Case-control studies were identified by searching databases of PubMed, EMBASE, Web of Science, CNKI, CBM, Wanfang, and VIP. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association.Results: The UBQ-8i polymorphism was significantly associated with an increased AD risk (OR=1.15; 95%CI 1.05-1.25; P=0.002). The combination of adjusted ORs also found UBQ-8i polymorphism was significantly associated with AD risk (OR=1.15; 95%CI 1.02-1.30; P=0.02). When stratified by APOE e4 status, both APOE e4 carriers and APOE non-e4 carriers with UBQ-8i polymorphism had significantly increased AD risk (OR=1.28; 95%CI 1.05-1.56; P=0.01 and OR=1.25; 95%CI 1.04-1.50; P=0.02). In the subgroup analysis according to age, UBQ-8i polymorphism was significantly associated with LOAD risk (OR=1.17; 95%CI 1.05-1.31; P=0.005), but not with EOAD risk (OR=1.12; 95%CI 0.95-1.31; P=0.17).Conclusions: These results suggest that the UBQ-8i polymorphism is associated with AD risk. © Med Sci Monit, 2014.


Yu L.-P.,Nanjing Medical University | Qian W.-W.,Peoples Hospital | Yin G.-Y.,Nanjing Medical University | Ren Y.-X.,Nanjing Medical University | Hu Z.-Y.,Nanjing Medical University
PLoS ONE | Year: 2012

Background: To evaluate by MRI intervertebral disc degeneration in patients with lumbar degenerative disease using the Pfirrmann grading system and to determine whether Modic changes correlated with the Pfirrmann grades and modified Pfirrmann grades of disc degeneration. Methods: The clinical data of 108 surgical patients with lumbar degenerative disease were reviewed and their preoperative MR images were analyzed. Disc degeneration was evaluated using the Pfirrmann grading system. Patients were followed up and low back pain was evaluated using the visual analog scale (VAS) and the effect of back pain on the daily quality of life was assessed using Oswestry disability index (ODI). Results: Forty-four cases had normal anatomical appearance (Modic type 0) and their Pfirrmann grades were 3.77±0.480 and their modified Pfirrmann grades were of 5.81±1.006. Twenty-seven cases had Modic type I changes and their Pfirrmann grades were 4.79±0.557 and their modified Pfirrmann grades were 7.00±0.832. Thirty-six cases exhibited Modic type II changes and their Pfirrmann grades and modified Pfirrmann grades were 4.11±0.398 and 6.64±0.867, respectively. One case had Modic type III changes. Kruskal-Wallis test revealed significant difference in modified Pfirrmann grade among Modic type 0, I and II changes (P<0.01) but no significant difference between Modic type I and II changes (P>0.05). Binary regression analysis showed that Modic changes correlated most strongly with disc degeneration. Follow up studies indicated that the VAS and ODI scores were markedly improved postoperatively. However, no difference was noted in VAS and ODI scores among patients with different Modic types. Conclusion: Modic changes correlate with the Pfirrmann and modified Pfirrmann grades of disc degeneration in lumbar degenerative disease. There is no significant correlation between Modic types and surgical outcomes. © 2012 Yu et al.


Rashmi G.,Peoples Hospital
Indian Journal of Otology | Year: 2010

Objective: This study was done to compare the efficacy of tympanoplasty Type I alone versus tympanoplasty with cortical mastoidectomy in patients with chronis suppurative otitis media (CSOM) of tubotympanic variety. Design: A prospective study. Setting: Academic tertiary refferal center. Methods: 80 patients of CSOM were divided into 2 groups . Group A Includes 40 patients with dry central perforation managed by Type I Tympanopasty. Group B includes 40 patients with moist, wet middle ear and sclerosed mastoid managed by tympanoplasty type-I with cortical mastoidectomy. Results: The patients age ranged from 10-60 years with best hearing improvement of 13.25 dB was found in younger age group (11-,20 years). 33 patients with bilateral ear disease were operated with only one failure. Status of nonoperated ear did not affect the outcome in our study, overall Graft success rate was 90% in Group A and 97.5% in Group B, mean, postoperative airbone gap were 14.42 dB and 1 7.52 dB respectively. We could, not find any significant statistical difference in hearing gain between two groups but graft success rate was definitely better in group B. Conclusion: It is not necessary to explore the mastoid routinely in all cases of CSOM (TT) but it is definitely helpful in sclerosed contracted mastoid with oedmatous polypoidal middle ear mucosa to remove aditus block.


Jiao J.,Peoples Hospital | Mo B.,Capital Medical University | Wei H.,Peoples Hospital | Jiang Y.-R.,Peoples Hospital
Graefe's Archive for Clinical and Experimental Ophthalmology | Year: 2013

Purpose: The purpose of this study was to demonstrate the value of a quantitative study concerning experimental choroidal neovascularization (CNV) tissue by correlating the paraffin sections and frozen sections with optical coherence tomography (OCT) images. Methods: After OCT imaging was performed, four right eyes from the normal Brown Norway (BN) rats were made into paraffin sections and four left eyes were made into frozen sections. Laser photocoagulation was performed on the right eyes of the other 32 BN rats to induce CNV; these rats then were divided into two groups. After the OCT imaging was performed, four eyes were made into serial paraffin sections in Group A or frozen sections in Group B at 1 week after laser photocoagulation, and weekly for 4 weeks. A quantitative comparison of histopathological images and OCT images was performed. Results: The thickness of the sensory retina and choroid of normal BN rats in paraffin sections was perceptibly less than that in the frozen sections, and the thickness of the sensory retina in the frozen sections was similar to that measured in the OCT images. The maximum thickness of the CNV tissue in the frozen sections was greater than that in the paraffin sections, but similar to that measured in the OCT images from week 1 to week 4. Conclusions: Only the frozen sections accurately matched the high-resolution OCT images because of the processing artifacts in the paraffin sections. In further quantitative studies on experimental CNV, the frozen sections may be more preferable if the thickness of the CNV tissue is to be measured and compared. © 2012 Springer-Verlag Berlin Heidelberg.


Gupta S.,Peoples Hospital
Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH | Year: 2011

This case is related to a 52-year-old lady with proptosis, diplopia and diminution of vision due to a mass lesion in upper medial quadrant of the orbit. CT scan revealed a well defined mass in basi-frontal area with intra-orbital and intracranial extension. On exploring it was found to be mucopyocele of the frontal sinus. Surgical excision was done by external approach. The symptoms and signs resolved completely within a week. Frontal sinus mucopyoceles are benign and curable. Early recognition and management of them is of paramount importance because they can expand and cause local, orbital or intracranial complications. © NEPjOPH.


Miao H.,Peoples Hospital | Tao Y.,Peoples Hospital | Jiang Y.-R.,Peoples Hospital | Li X.-X.,Peoples Hospital
Graefe's Archive for Clinical and Experimental Ophthalmology | Year: 2013

Background: Cytomegalovirus (CMV) infection is a major cause of morbidity and mortality in patients after hematopoietic stem cell transplantation (HSCT). Although much effort has been put into dealing with CMV retinitis secondary to acquired immunodeficiency syndrome (AIDS), the few reports which have been published have mainly focused on treatment of CMVR after HSCT. Methods: This clinical interventional retrospective study included 14 patients (eight men; mean age 23.89 ± 12.09; 23 eyes) who suffered from CMV retinitis after stem-cell transplantation, in order to evaluate the efficacy and safety of multiple intravitreal injections of ganciclovir (IVG) for patients with CMV retinitis. All patients received 4 injections of IVG of 1 mg at 1 week intervals, and were followed up weekly for at least 2 months with measurement of best-corrected visual acuity (BCVA) and CMV levels in anterior aqueous humor with real-time polymerase chain reaction. Anterior aqueous humor was obtained before each injection. Results: The levels of CMV in anterior aqueous humor showed significant decrease from (6.34 ± 15.78) × 105 copies/ml at baseline to (5.22 ± 12.15) × 103 copies/ml at 1 month (P < 0.001, Mann-Whitney U test). CMV couldn't be detected in 11 eyes (47.8 %) after two injections, and this rose to 18 eyes (78.3 %) at 1 month. The mean logMAR BCVA was 0.659 ± 0.572 at baseline and 0.680 ± 0.527 at 2 months, which suggested no significant improvement (P = 0.736, Mann-Whitney U test) during the procedure. All patients experienced improved vitreous opacity and diminished area of the lesion under funduscopy after 4 injections of IVG. No severe complications developed. Conclusions: Multiple IVG seemed to be beneficial for patients with CMV retinitis after stem-cell transplantation, in reducing CMV levels in aqueous humor. Further study to optimize the dose of ganciclovir is needed in order to achieve better treatment outcomes. © 2013 Springer-Verlag Berlin Heidelberg.

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