People Hospital of Guangxi Zhuang Autonomous Region

Nanning, China

People Hospital of Guangxi Zhuang Autonomous Region

Nanning, China
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Xiaoxia H.,People Hospital of Guangxi Zhuang Autonomous Region | Kangkang Z.,People Hospital of Guangxi Zhuang Autonomous Region | Xianglan M.,People Hospital of Guangxi Zhuang Autonomous Region | Fei L.,People Hospital of Guangxi Zhuang Autonomous Region | Wenjing Z.,People Hospital of Guangxi Zhuang Autonomous Region
Cancer Research and Clinic | Year: 2014

Objective: To investigate the expression of miR-218 in cervical cancer tissues and bioinformatically analyze the target genes of miR-218 to provide theoretical basis on further studies of miR-218 functions in cervical cancer. Methods: miRNA array was applied to detect miRNA expression profile in cervical cancer tissues, and real-time RT-PCR was used for validation. The bioinformatic analysis of the target genes of miR-218 involved gene ontology and signal transduction pathway enrichment was performed. Results: miR-218 expression significantly decreased in cervical cancer tissues compared with that of normal cervical tissues. The functions of predicted target genes of miR-218 were enriched in biological regulation, adhesion and motion, proteometabolism, cellular differentiation, protein binding and other biological processes and molecular functions. According KEGG pathway database, the predicted target genes involved in pathway in cancer, adherent junction, focal adhesion, prostate cancer, chronic myeloid leukemia, melanoma, and other signal transduction pathways. Conclusions: miR-218 expression significantly decreases in cervical cancer tissues. Some of the predicted target genes of miR-218 are significandy enriched in tumor related with signaling pathways.

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