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Abar B.W.,Pennsylvania State University | Turrisi R.,Pennsylvania State University | Hillhouse J.,East Tennessee State University | Loken E.,Pennsylvania State University | And 2 more authors.
Health Psychology | Year: 2010

Objectives: To evaluate the effects of an appearance-focused intervention to reduce the risk of skin cancer by decreasing indoor tanning, examine potential heterogeneity in tanning across this time, and correlate the subtypes with predictors collected at baseline. Design: Randomized controlled trial with 379 female college students measured at 6 monthly time points. Main Outcome Measure: Self-reported indoor tanning frequency. Results: The intervention was effective at decreasing tanning over the period between the fall and spring. Longitudinal latent class analysis found 3 patterns of tann1ers among the treatment individuals: abstainers, moderate tanners, and heavy tanners. These classes appeared in both the treatment and control conditions, and the intervention had a harm reduction effect by reducing levels of exposure within the moderate and heavy tanner classes. Participant age and self-reported tanning patterns were found to be predictive of class membership. Conclusions: This research suggests that brief intervention approaches can be effective at reducing risk for skin cancer and illustrates several ways in which these protective effects can be enhanced. © 2010 American Psychological Association.

Roszelle B.N.,Pennsylvania State University | Deutsch S.,Pennsylvania State University | Weiss W.J.,Pennsylvania State University | Weiss W.J.,Pennsylvania State Milton rshey Medical Center | Manning K.B.,Pennsylvania State University
Annals of Biomedical Engineering | Year: 2011

The aim of this study is to define the fluid mechanics of a pulsatile pneumatically driven pediatric ventricular assist device (PVAD), for the reduced flow rates encountered during device weaning and myocardial recovery, and relate the results to the potential for thromboembolic events. We place an acrylic model of the PVAD in a mock circulatory loop filled with a viscoelastic blood analog and operate at four stroke volumes (SVs), each with two different filling conditions, to mimic how the flow rate of the device may be reduced. Particle image velocimetry is used to acquire flow field data. We find that a SV reduction method provides better rotational flow and higher wall shear rates than a beat rate reduction method; that a quick filling condition with a compressed diastolic time is better than a slow filling condition; and, that a reduction in SV to 40% led to greatly reduced fluid movement and wall shear rates that could increase the thrombogenicity of the device. SV reduction is a viable option for flow reduction during weaning, however, it does lead to significant changes to the device flow field and future studies are needed to develop operational protocols for the PVAD during bridge-to-recovery. © 2011 Biomedical Engineering Society.

Payne R.,Penn State Milton rshey Medical Center | Sieg E.,Penn State Milton rshey Medical Center | Fox E.,Pennsylvania State Milton rshey Medical Center | Harbaugh K.,Penn State Milton rshey Medical Center | Rizk E.,Penn State Milton rshey Medical Center
Child's Nervous System | Year: 2016

Purpose: Multiple hereditary exostoses (MHE) is a rare autosomal dominant condition that results in the growth of cartilage-capped prominences that often cause nerve compression and injury. Many patients suffer from continued and debilitating chronic pain which leads some to advocate avoiding surgical intervention in patients with multiple hereditary exostoses. We present a review of the literature as well as a case series at our institution in order to evaluate the role of surgery in multiple hereditary exostoses. Methods: We searched the literature for reports of patients with multiple hereditary exostoses undergoing surgery for nerve compression. We then reviewed the recent experience at our institution which revealed two patients with multiple hereditary exostoses. Results: Our literature search revealed that there have been several case series and retrospective analyses in the literature that assess the benefit of surgery in the case of nerve compression caused by exostoses. The majority of these reports are of solitary exostoses. Few reports expand on the role of surgery in patients with multiple hereditary exostoses suffering from nerve compressions secondary to bony overgrowth. A recent review of the experience at our institution revealed two patients with multiple hereditary exostoses who together underwent a total of four surgeries for treatment of peripheral nerve compression resulting in pain or weakness. Postoperative evaluation revealed improvement in pain and/or motor strength following each operation. Conclusion: Based on our experience and literature review, we advocate that nerve compression in selected individuals with multiple hereditary exostoses that results in neurological injury should be considered for nerve decompression and resection of the offending exostosis. © 2016 Springer-Verlag Berlin Heidelberg

Adair J.H.,Pennsylvania State University | Adair J.H.,Keytone Nano Inc. | Parette M.P.,Keytone Nano Inc. | Altinoglu E.I.,Pennsylvania State University | And 2 more authors.
ACS Nano | Year: 2010

The ability to apply nanomaterials as targeted delivery agents for drugs and other therapeutics holds promise for a wide variety of diseases, including many types of cancer. A nanodelivery vehicle must demonstrate in vivo efficacy, diminished or no toxicity, stability, improved pharmacokinetics, and controlled-release kinetics. In this issue, Lee et al.construct polymer nanobins that fulfill these requirements and demonstrate effective delivery of doxorubicin in vivo to breast cancer cells. This Perspective explores the outlook for these nanobins as well as other technologies in this field and the challenges that lie ahead. © 2010 American Chemical Society.

Salvaggio H.L.,Pennsylvania State University | Zaenglein A.L.,Pennsylvania State University | Zaenglein A.L.,Pennsylvania State Milton rshey Medical Center
Pediatric Dermatology | Year: 2012

The sight of needles and surgical equipment can often cause anxiety in children. We describe the use of "Magic Goggles," a distraction technique of use in pediatric dermatology procedures. © 2012 Wiley Periodicals, Inc.

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