Beijing, China
Beijing, China

Peking University , is a major Chinese research university located in Beijing and a member of the C9 League. It is the first established modern national university of China, founded as the "Imperial University of Peking" in 1898 as a replacement of the ancient Guozijian. By 1920, it had become a center for progressive thought. It has been consistently regarded by both domestic and international university rankings as, alongside Tsinghua University, the top higher learning institution in mainland China. In addition to academics, Peking University is especially renowned for its campus grounds, and the beauty of its traditional Chinese architecture.Throughout its history, the university has educated and hosted many prominent modern Chinese thinkers, including figures such as: Lu Xun, Mao Zedong, Gu Hongming, Hu Shih, Li Dazhao, and Chen Duxiu. Peking University was influential in the birth of China's New Culture Movement, May Fourth Movement, the Tiananmen Square protest of 1989 and many other significant events. Wikipedia.


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Patent
Peking University, Pkucare Pharmaceutical R&D Center and Pku Healthcare Industry Group Co. | Date: 2014-12-30

The present invention provides a polysubstituted pyridine compound of Formula I, a preparation method, a use and a pharmaceutical composition thereof. The polysubstituted pyridine compound of Formula I according to the present invention has an excellent anti-tumor effect, can inhibit various cell kinases simultaneously, has significantly excellent pharmacokinetic characteristics, and is very suitable for oral and intravenous administration. The pharmaceutical composition according to the present invention can be useful for treating tumors and cancers.


Patent
Peking University, Pkucare Pharmaceutical R&D Center and Pku Healthcare Industry Group Co. | Date: 2017-02-15

The present invention provides a polysubstituted pyridine compound of Formula I, a preparation method, a use and a pharmaceutical composition thereof. The polysubstituted pyridine compound of Formula I according to the present invention has an excellent anti-tumor effect, can inhibit various cell kinases simultaneously, has significantly excellent pharmacokinetic characteristics, and is very suitable for oral and intravenous administration. The pharmaceutical composition according to the present invention can be useful for treating tumors and cancers.


Patent
ZTE Corporation and Peking University | Date: 2017-01-18

A method for compressing a local feature descriptor includes that: at least one local feature descriptor of a target image is selected; and multi-stage vector quantization is carried out on the selected at least one local feature descriptor according to a pre-set code book, and the local feature descriptor is quantized as a feature code stream, wherein the feature code stream includes serial numbers of code words obtained by means of the multi-stage vector quantization. A device for compressing a local feature descriptor and a storage medium are also provided.


The present invention relates to a rare earth-based nanoparticle magnetic resonance contrast agent and a preparation method thereof. The rare earth-based nanoparticle magnetic resonance contrast agent is rare earth-based inorganic nanoparticles having the surfaces coated with hydrophilic ligands. The rare earth-based nanoparticles are first obtained by a high-temperature oil phase reaction, and then the surfaces thereof are coated with hydrophilic molecules to obtain the rare earth-based nanoparticle magnetic resonance contrast agent. Compared with the existing clinical contrast agent, the magnetic resonance contrast agent of the present invention has a greatly improved relaxivity, a good imaging effect, a low required injection dose, and long in vivo residence time. In addition, the rigid structure of the inorganic nanoparticles can effectively reduce the leakage possibility of gadolinium ions.


Patent
Peking University | Date: 2014-11-14

An adaptive voltage source, comprising a signal output end, and a reference resistance forming circuit and a sensing module connected in series between a voltage source and a low power level; the sensing module comprises a sensing end coupled to a transistor to be sensed to sense the threshold voltage drift of the transistor to be sensed in a device circuit; the equivalent resistance of the sensing module increases with the increase of the sensed threshold voltage drift; and the signal output end is coupled to a first node coupled to the reference resistance forming circuit and the sensing module, and is used to output adaptive voltage. The output adaptive voltage is adjusted via the threshold voltage drift sensed by the sensing module. Based on the circuit, also disclosed are a shift register and unit thereof, and display.


Patent
Peking University and Beijing Ruipu Chenchuang Technology Co. | Date: 2017-06-14

Disclosed is a use of a SUSD2 protein as a marker, in particular a use of the SUSD2 protein as the marker in identification, selection or separation of pancreatic internal secretion precursor cells and/or newborn pancreatic internal secretion cells; and a use of an mRNA, for encoding the SUSD2 protein, of a precursor protein as the marker in identification of the pancreatic internal secretion precursor cells and/or the newborn pancreatic internal secretion cells. Through analysis of gene expression of pancreatic endoderm cells sourced by induced directional differentiation of human pluripotent stem cells, the enrichment expression of a SUSD2 gene in the pancreatic internal secretion precursor cells and the newborn pancreatic internal secretion cells is found. In addition, a protein encoded by the SUSD2 gene is a receptor protein on cell membranes. Using the protein as the marker, the identification, the selection or the separation of the pancreatic internal secretion precursor cells and the newborn pancreatic internal secretion cells can be carried out, which has an important significance on research about pancreas related cells in each development stage.


The invention discloses a compound having branching alkyl chains, the method for preparing the same and use thereof in photoelectric devices. By applying the branching alkyl chains as the solubilizing group to the preparation of organic conjugated molecules (for example, organic conjugated polymers), the number of methylenes between the resultant alkyl side chains and the backbone, i.e., m>1, which can effectively reduce the effect of the alkyl chains on the backbone - stacking, thereby ensuring the solubility of the organic conjugated molecule while greatly increasing the mobility of their carriers. It is suitable for an organic semiconductor material in photoelectric devices such as organic solar cells, organic light emitting diodes and organic field effect transistors, etc.


Patent
Peking University and Beijing Ruipu Chenchuang Technology Co. | Date: 2015-08-04

SUSD2 protein is used as a marker in identification, selection or separation of pancreatic internal secretion precursor cells and/or newborn pancreatic internal secretion cells; and a use of an mRNA, for encoding the SUSD2 protein, of a precursor protein as the marker in identification of the pancreatic internal secretion precursor cells and/or the newborn pancreatic internal secretion cells. Analysis of gene expression of pancreatic endoderm cells sourced by induced directional differentiation of human pluripotent stem cells finds the enrichment expression of a SUSD2 gene in the pancreatic internal secretion precursor cells and the newborn pancreatic internal secretion cells. A protein encoded by the SUSD2 gene is a receptor protein on cell membranes. Using the protein as the marker, the identification, the selection or the separation of the pancreatic internal secretion precursor cells and the newborn pancreatic internal secretion cells can be conducted.


Patent
Peking University | Date: 2017-02-25

A multi-domain centralized content-centric networking (MCCN), including: a management layer; a control layer; and a data layer. The management layer communicates with the data layer through the control layer. The management layer is configured to acquire application transmission requests, network resource allocation, and network running status, and give network operating commands to a control plane according to reconfiguration of management strategies. The control layer is configured to carry out routing establishment, maintain network topology of domains, inform the management layer of network status, and execute commands of the management layer. The data layer is configured to process data packet according to commands of the control layer. The task of the data layer is completed by a router and link of the bottom layer.


Patent
Beihao Stem Cell And Regenerative Medicine Translational Research Institute, Peking University and Beijing Vitalstar Biotechnology Co. | Date: 2015-02-04

A method for inducing reprogramming of a cell of a first type which is not a non-hepatocyte (non-hepatocyte cell), into a cell with functional hepatic drug metabolizing and transporting capabilities, is disclosed. The non-hepatocyte is induced to express or overexpress hepatic fate conversion and maturation factors, cultured in somatic cell culture medium, hepatocyte cell culture medium and hepatocyte maturation medium for a sufficient period of time to convert the non-hepatocyte cell into a cell with hepatocyte-like properties. The iHeps induced according to the methods disclosed herein are functional induced hepatocytes (iHeps) in that they express I and II drug-metabolizing enzymes and phase III drug transporters and show superior drug metabolizing activity compared to iHeps obtained by prior art methods. The iHeps thus provide a cell resource for pharmaceutical applications.

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