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Paz F.,Catholic University of Peru | Paz F.A.,Pedro Ruiz Gallo National University | Pow-Sang J.A.,Catholic University of Peru
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

According to the Semiotic Engineering, the human-computer interaction is a way of communication between designers and users. The Communicability Evaluation Method (CEM) is a technique to assess this communication and determine the degree in which the designers achieve to convey users their design intents through the system interface. Most case studies that are described in the literature are focused on the evaluation of desktop applications. In this study, we present the results of a communicability evaluation to a transactional Web application. The experimental case was run by three specialists in the field of HCI and involved the participation of four university students from two academic programs in Computing. These users had to perform some tasks that were developed based on the results of a previous work. After an analysis of the interactions, we concluded that the Website can be difficult to use by users with no experience in the use of this type of software. There are certain aspects of the interface design that should be improved. © Springer International Publishing Switzerland 2016.


Aguilar C.,Hospital Nacional Edgardo Rebagliati Martins | Ventura F.,Trujillo National University | Rodriguez-Delfin L.,Hospital Nacional Edgardo Rebagliati Martins | Rodriguez-Delfin L.,Pedro Ruiz Gallo National University
Revista Peruana de Medicina Experimental y Salud Publica | Year: 2011

Objectives. This study has investigated the effect of atorvastatin on the progression of cardiac remodelling and ACE- 2 expression in diabetic myocardium in rats. Materials and Methods. Diabetes was induced in Holtzman rats with an intraperitoneal injection of streptozotocin. The animals were divided into 3 groups: (1) normal control rats, (2) diabetic rats and (3) diabetic rats treated orally with atorvastatin (50 mg/kg/day). After eight weeks of treatment, the hearts were removed for morphometric studies, collagen content assay and genetic expressions of ACE and ACE2 mRNA. Results. Myocardial hypertrophy index and collagen deposition were increased in diabetic rats, but not in the treated-diabetic rats, without producing changes in cholesterol levels. Myocardial ACE mRNA levels were increased while ACE2 mRNA levels were decreased in diabetic rats. Atorvastatin administration attenuated overexpression of ACE mRNA and overexpression of ACE-2 mRNA in diabetic rats. Conclusions. Our results indicate that atorvastatin, independently of its cholesterol-lowering capacity, lowers the ACE/ACE2 ratio to normal values and attenuates the development of adverse remodeling in the diabetic heart.


Aguilar C.,Hospital Nacional Edgardo Rebagliati Martins | Rodriguez-Delfin L.,Pedro Ruiz Gallo National University | Rodriguez-Delfin L.,Laboratorio Of Investigacion Y Diagnostico
Revista Peruana de Medicina Experimental y Salud Publica | Year: 2012

Objectives. Evaluate the effect of spironolactone (SPL) on the loss of podocytes during the progression of experimental diabetic nephropathy (DN). Materials and methods. A group of male Holtzman rats randomly received streptozotocin (diabetic group) or a buffer citrate (control group). Diabetic rats were treated with SPL (50 mg/kg/day). The glomerular area and the cellularity were evaluated by histomorphometric methods. The injury and loss of podocytes was assessed by desmin expression and Wt-1, respectively. The gene expression of TGF-β1 was assessed by RT-PCR. Results. Glucose levels, the glomerular area, the mesangial expansion and collagen content increased significantly in diabetic rats. The administration of SPL prevented these changes without changing glucose levels. Immunostain for Wt-1 decreased significantly while immunostain for desmin increased dramatically in diabetic rats. Treatment with SPL prevented the increase of desmin expression and the loss of Wt-1 expression. Furthermore, the administration of SPL prevented the increase of TGF-β1 mRNA expression in diabetic rats. Conclusions. Treatment with SPL, through independent glucose effects, reduces the loss of podocytes and the progression of DN morphological changes. These results suggest that these effects are mediated, at least in part, by the inhibition of TGF-β1 mRNA expression.


Paz F.,Catholic University of Peru | Paz F.A.,Pedro Ruiz Gallo National University | Pow-Sang J.A.,Catholic University of Peru
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2015

A widely used method to measure the level of usability of software applications is the heuristic evaluation. In this method, specialists commonly use the Nielsen’s heuristics to assess the usability of a software product. However, these principles address to general aspects and become inappropriate when they are used to evaluate new categories of software applications. For this reason, we previously proposed a new set of usability heuristics in the Web transactional domain. In this paper, we present an empirical analysis of our new proposal. For this purpose, fifteen undergraduate students were asked to perform a heuristic evaluation in which the new set of heuristics were employed. A survey was taken in order to capture their perceptions about the heuristics in four dimensions: ease of use, usefulness, intention to use and completeness. The results showed that the new heuristics meet the expectations. In addition, this analysis was compared with the results of a similar study that was performed to the current proposal of Nielsen. The results from this study have allowed to reach promising results in this area. © Springer International Publishing Switzerland 2015.


Celi E.,Pedro Ruiz Gallo National University
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2015

The process of education of students and professional training in themes such as IT Risk Management entails use frameworks such as Magerit or Octave. The understanding of these frameworks becomes difficult when learning sessions are short, even if we use specific software, due to the large number of elements to identify, understand, relate and apply. Using dashboards and scorecards prepared in tools like Excel helps enhance this learning. The purpose of this study was to measure the usability and effectiveness in achieving the expected outcomes, evaluating the experience of users through questionnaires type System Usability Usability Scale (SUS); and to examine the needs and expectations of users. The results show that participants learn faster the practical application of the frameworks studied, because the dashboards and scorecards allows them easier to identify its elements and its practical application. © Springer International Publishing Switzerland 2015.

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