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Rio de Janeiro, Brazil

Machado D.E.,Centro Universitario Estadual da Zona Oeste | Perini J.A.,Centro Universitario Estadual da Zona Oeste | Orlando M.M.C.,University Hospital Pedro Ernesto | Santos-Oliveira R.,Laboratory of Nanoradiopharmaceuticals
BioMed Research International | Year: 2015

The off-label use of bevacizumab labeled with 99mTc as a new radiopharmaceutical for imaging of endometriosis is a promising noninvasive, new clinical procedure. The bevacizumab in monoclonal antibodies targeted at vascular endothelial growth factor (VEGF) is superexpressed in cases of endometriosis. In this study we evaluate the imaging of endometriosis lesion in rats (induced to endometriosis) using bevacizumab-99mTc. The results showed that bevacizumab-99mTc imaged the lesion and support his use for Nuclear Medicine applied to gynecology. Also the results appointed that this radiopharmaceutical has a hepatobiliary excretion. It is important to notice that the dose used was almost 0,01% of the usual dose for the bevacizumab. Copyright © 2015 Daniel Escorsim Machado et al. Source

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