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Firenze, Italy

Camerota M.,Pedology | Simoni S.,Pedology | Di Giaimo R.,University of Naples Federico II | Bouneb M.,Pedology | Roversi P.F.,Pedology

Wolbachia pipiensis (Hertig et Wolbach, 1924) is known to manipulate the exprebion of genes implicated in the metabolism, immunity and reproduction in Drosophila melanogaster (Meigen, 1830). Under streb, cells activate the cellular streb response (CSR). The CSR is a conserved network of pathways regulating identification, check and response to streb, preserving the cellular homeostasis. The CSR involves the unfolded protein response, autophagy, the heat shock response and other subcellular pathways. How Wolbachia affects the CSR has not yet been investigated. Here, we report the influence of Wolbachia infection and cold streb on the exprebion of the Heat-shock-protein-70Aa (Hsp70Aa), Autophagy-related gene-1 (Atg1) and X box binding protein-1 (Xbp1) genes and the influence of cold streb on the Wolbachia surface protein gene (wsp). The Hsp70Aa, Atg1, and Xbp1 genes were affected by Wolbachia infection since they were found to be up-regulated in the Wolbachia-free flies. After cold streb, the Wolbachia-infected flies showed high exprebion of the Atg1 and Hsp70Aa genes in comparison to the Wolbachia-free flies. Moreover, cold streb negatively influenced the exprebion of the wsp gene. Source

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