Side effects of immunosuppressive therapy in children with aplastic anemia treated with rabbit anti-thymocyte globulin [Powikłania leczenia immunoablacyjnego u dzieci z anemia̧ aplastyczna̧ leczonych globulina̧ antytymocytarna̧ pochodzenia króliczego]
Salamonowicz M.,Pediatryczna Grupa Ds. Nienowotworowych Chorob Ukladu Krwiotworczego |
Pawelec K.,Pediatryczna Grupa Ds. Nienowotworowych Chorob Ukladu Krwiotworczego |
Matysiak M.,Pediatryczna Grupa Ds. Nienowotworowych Chorob Ukladu Krwiotworczego |
Balwierz W.,Pediatryczna Grupa Ds. Nienowotworowych Chorob Ukladu Krwiotworczego |
And 17 more authors.
Onkologia Polska | Year: 2010
Introduction: In patients with acquired aplastic anemia (SAA) allogenic bone marrow transplantation is the best way of treatment. If there is no matched sibling donor the best choice is immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG), actually rabbit ATG. The aim of this study was to analyze the side effects of IST containing rabbit ATG used in children with SAA. Material and methods: We analyzed retrospectively group of 55 children treated with rabbit ATG in ten Polish Paediatric Hematological Centers between 1996-2009. The median age was 10 years (range 6 mth-17,5 years). There were 7 patients with vSAA and 48 with SAA. Results: On 180 day we found CR in 6 patients (11%) and PR in 23children. On 360 day 10 cases (18%) had CR and 20 cases (36%) revealed PR. Infections were the most often side effects of IST and also the main reason of death .The most often infectious side effects was FUO. After CSA we observed mainly gingival hyperplasia There was no coincidence between the length of using colony stimulating factors and amount of infections or other adverse effects. Conclusions: 1. The infections are the most often side effects of IST, and the main reason of death in children with SAA. 2. FUO is one of the most common infectious complication. 3.Period of using colony stimulating factors doesn't influence number of infectious complications. Copyright © 2010 Cornetis. Source