Dhodapkar M.V.,Yale University |
Dhodapkar K.M.,Pediatrics Hematology Oncology |
Dhodapkar K.M.,Yale University
Seminars in Oncology | Year: 2015
rapeutic potential of immune system in context of hematologic malignancies has long been appreciated particularly due to curative impact of allogeneic hematopoietic stem cell transplantation (SCT). role of immune system in shaping biology and evolution of se tumors is now well recognized. While contribution of immune system in anti-tumor effects of certain rapies such as immune-modulatory drugs and monoclonal antibodies active in hematologic malignancies is quite evident, immune system has also been implicated in anti-tumor effects of or targeted rapies. Horizon of immune-based rapies in hematologic malignancies is rapidly expanding with promising results from immune-modulatory drugs, immune-checkpoint blockade, and adoptive cellular rapies, including genetically-modified T cells. Hematologic malignancies present distinct issues (relative to solid tumors) for application of immune rapies due to differences in cell of origin/developmental niche of tumor cells, and patterns of involvement such as common systemic involvement of secondary lymphoid tissues. This article discusses rapidly changing landscape of immune modulation in hematologic malignancies and emphasizes areas wherein hematologic malignancies present distinct opportunities for immunologic approaches to prevent or treat cancer. © 2015 Elsevier Inc.All rights reserved.