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Milano, Italy

Patria M.F.,University of Milan | Longhi B.,University of Milan | Lelii M.,University of Milan | Galeone C.,University of Milan | And 2 more authors.
Italian Journal of Pediatrics | Year: 2013

Background: There are few published data concerning radiological findings and their relationship with community-acquired pneumonia (CAP) severity. The aim if this study was to assess radiographic findings in children with CAP of different severity in order to evaluate whether some parameters are associated with severe CAP. Methods. We analysed the characteristics of parenchymal densities in 335 chest radiographs of otherwise healthy children (173 males; mean age ± standard deviation, 7.5 ± 4.5 years) admitted to our Emergency Room for CAP. Upon admission, chest radiographs were obtained in the two standard projections, and the children with severe or mild/moderate CAP were compared in order to identify any correlations between CAP severity and the radiological findings. Results: Seventy-six of the 335 enrolled children (22.7%) fulfilled the criteria for severe CAP. In comparison with the children with mild/moderate CAP, in severe CAP there was a significantly greater frequency of a bilateral multifocal distribution (p = 0.01), the simultaneous involvement of ≥3 sites (p = 0.007), and the involvement of the right hilum (p = 0.02). The same results were confirmed in the multiple logistic regression model. Conclusions: This study shows that radiological findings such as a multifocal bilateral distribution, the simultaneous involvement of at least three sites, and right hilar consolidation are associated with severe CAP in otherwise healthy children, and could be considered markers of disease severity in children with CAP. © 2013 Patria et al.; licensee BioMed Central Ltd.

Gautschi M.,University of Bern | Merlini L.,Pediatric Radiology Unit | Calza A.-M.,University of Geneva | Hayflick S.,Oregon Health And Science University | And 2 more authors.
European Journal of Paediatric Neurology | Year: 2014

Fucosidosis is a rare lysosomal storage disease. A 14-year-old girl is presented, with recurrent infections, progressive dystonic movement disorder and mental retardation with onset in early childhood. The clinical picture was also marked by mild morphologic features, but absent dysostosis multiplex and organomegaly. MRI images at 6.5 years of age were reminiscent of pallidal iron deposition ("eye-of-the-tiger" sign) seen in neurodegeneration with brain iron accumulation (NBIA) disorders. Progressively spreading angiokeratoma corporis diffusum led to the correct diagnosis. This case extends the scope of clinical and neuroradiological manifestations of fucosidosis. © 2014 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

Printza N.,Aristotle University of Thessaloniki | Ververi A.,Aristotle University of Thessaloniki | Bandouraki M.,Pediatric Radiology Unit | Vargiami E.,Aristotle University of Thessaloniki | And 2 more authors.
Urologia Internationalis | Year: 2012

Neonatal urinary ascites is a rare entity, usually associated with a spontaneous rupture of the bladder with an underlying pathology such as high pressure or wall disruption. Its presentation involves abdominal distension, metabolic derangement and respiratory compromise. We report the case of a male neonate with solitary functioning kidney presented with life-threatening persistent hyponatremia and acute renal failure due to iatrogenic bladder rupture after catheterization. The aim of our report is to raise awareness on the possibility of bladder perforation in neonates even in the absence of technical faults. We discuss the uncommon presentation of our case and highlight the need for early recognition and management of urinary ascites, addressing all subspecialties involved in diagnostic or therapeutic procedures of neonates with urinary abnormalities. © 2011 S. Karger AG, Basel.

Faundez T.,Child and Adolescent | Klee P.,Endocrinology and Diabetes Unit | Hanquinet S.,Pediatric Radiology Unit | Schwitzgebel V.,Endocrinology and Diabetes Unit | And 2 more authors.
Pediatrics | Year: 2016

Diabetic striatopathy is a well-known complication of diabetes in adults. To our knowledge, only 2 cases have been reported in children. We here report the case of a teenager in whom diabetic striatopathy was revealed by the subacute appearance of hemichorea-hemiballism in the context of weight loss, polyuria, and polydipsia. Glycemia control allowed rapid clinical recovery despite established striatal lesions documented on MRI. We also discuss current hypotheses about pathophysiological processes underlying this entity. © 2016 by the American Academy of Pediatrics.

Esposito S.,University of Milan | Daleno C.,University of Milan | Tagliabue C.,University of Milan | Scala A.,University of Milan | And 6 more authors.
European Journal of Clinical Microbiology and Infectious Diseases | Year: 2012

This study of 592 children seen in our Emergency Department with radiographically confirmed communityacquired pneumonia (CAP) was designed to evaluate the role of rhinoviruses (RVs) in the disease. The respiratory secretions of each child were assayed using RVP Fast in order to detect 17 respiratory viruses, and the RV-positive samples were characterised by means of real-time polymerase chain reaction and sequencing. RVs were identified in 172 cases (29.0%): 48/132 children aged <1 year (36.3%), 80/293 aged 1-3 years (27.3%), and 44/167 aged ≥4 years (26.3%). Sequencing demonstrated that 82 RVs (49.1%) were group A, 17 (10.1%) group B, and 52 (31.1%) group C; 21 (12.2%) were untyped. RVs were found as single agents in 99 cases, and together with two or more other viruses in 73 (40.7%). There were only marginal differences between the different RV groups and between single RV infection and RV coinfections. RV CAP is frequent not only in younger but also in older children, and RV-A is the most common strain associated with it. The clinical relevance of RV CAP seems to be mild to moderate without any major differences between the A and B strains and the recently identified RV C. © Springer-Verlag 2011.

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