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Caselli D.,Azienda Ospedaliera Meyer Children Hospital | Cesaro S.,Pediatric Hematology Oncology | Fagioli F.,Regina Margherita Childrens Hospital | Carraro F.,Regina Margherita Childrens Hospital | And 19 more authors.
Infectious Diseases | Year: 2016

Few data are available on the incidence of carbapenemase-producing Enterobacteriaceae (CPE) infection or colonization in children receiving anticancer chemotherapy. We performed a nationwide survey among centers participating in the pediatric hematology-oncology cooperative study group (Associazione Italiana Ematologia Oncologia Pediatrica, AIEOP). During a 2-year observation period, we observed a threefold increase in the colonization rate, and a fourfold increase of bloodstream infection episodes, caused by CPE, with a 90-day mortality of 14%. This first nationwide Italian pediatric survey shows that the circulation of CPE strains in the pediatric hematology-oncology environment is increasing. Given the mortality rate, which is higher than for other bacterial strains, specific monitoring should be applied and the results should have implications for health-care practice in pediatric hematology-oncology. © 2015 Society for Scandinavian Journal of Infectious Diseases.

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