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Le Touquet – Paris-Plage, France

Elowe-Gruau E.,Pediatric Endocrinology Gynecology | Elowe-Gruau E.,University of Paris Pantheon Sorbonne | Beltrand J.,Pediatric Endocrinology Gynecology | Beltrand J.,University of Paris Descartes | And 27 more authors.
Journal of Clinical Endocrinology and Metabolism | Year: 2013

Context: Craniopharyngioma is a brain tumor whose high local recurrence rate has for a long time led to a preference for extensive surgery. Limited surgery minimizing hypothalamic damage may decrease the severe obesity rate at the expense of the need for radiotherapy to complete the treatment. Objective: We compared weight gain and local recurrence rates after extensive resection surgery (ERS) and hypothalamus-sparing surgery (HSS). Design: Our observational study compared a historical cohort managed with ERS between 1985 and 2002 to a prospective cohort managed with HSS between 2002 and 2010. Setting: The patients were treated in a pediatric teaching hospital in Paris, France. Patients: Thirty-seven boys and 23 girls were managed with ERS (median age, 8 years); 38 boys and 27 girls were managed with HSS (median age, 9.3 years). Main outcome measures: Data were collected before and 6 months to 7 years after surgery. Body mass index (BMI) Z-score was used to assess obesity and the number of surgical procedures to assess local recurrence rate. Results: Mean BMI Z-score before surgery was comparable in the 2 cohorts (0.756 after ERS vs 0.747 after HSS; P = .528). At any time after surgery, mean BMI Z-score was significantly lower after HSS (eg, 1.889 SD vs 2.915 SD, P = .004 at 1 year). At last follow-up, the HSS cohort had a significantly lower prevalence of severe obesity (28% vs 54%, P < .05) and higher prevalence of normal BMI (38% vs 17%, P < .01). Mean number of surgical procedures was not significantly different in the 2 cohorts. Conclusions: Hypothalamus-sparing surgery decreases the occurrence of severe obesity without increasing the local recurrence rate. Copyright © 2013 by The Endocrine Society. Source

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