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Le na rd L.,Pe cs University Medical School | Le na rd L.,Pe cs University | Kova cs A.,Pe cs University Medical School | Ollmann T.,Pe cs University Medical School | And 4 more authors.
Behavioural Brain Research | Year: 2014

The amygdaloid body (AMY) plays an important role in memory, learning and reward-related processes. RFamide-related peptide-1 (RFRP-1) immunoreactive fibers and NPFF1 receptors were identified in the AMY, and previously we verified that neuropeptide RFRP-1 infused into the central nucleus of AMY (CeA) caused food intake decrease. The aim of the present study was to examine the possible rewarding or aversive effects of RFRP-1 in the CeA. In conditioned place preference, test male Wistar rats were microinjected bilaterally with 50 or 100. ng RFRP-1 in volume of 0.4. μl. In other groups of animals, 20. ng NPFF receptor antagonist RF9 was applied or the antagonist was used 15. min before 50. ng RFRP-1 treatment. Fifty nanograms of RFRP-1 had positive reinforcing properties, while 100. ng RFRP-1 had no effect. Prior treatment with NPFF receptor antagonist RF9 could block the rewarding effects of RFRP-1, while the antagonist applied alone did not influence the behavior of rats in place preference paradigm. Our results show that RFRP-1 and NPFF-1 receptors play important roles in the amygdaloid rewarding-reinforcing mechanisms. © 2014 Elsevier B.V.

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