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Dave D.J.,PDU Government Medical College | Dikshit R.K.,B J Medical College | Gandhi A.M.,B J Medical College
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2012

Background: Type 2 diabetes mellitus (DM), a common metabolic disorder, prevalence of which is predicted to rise in virtually every country with the greatest increase expected in developing countries. Modification in diet and life style are usually insufficient to provide good, long-term metabolic control of type 2 DM; pharmacological adjuvants are required in majority of patients. As there is no recommended regimen, it is difficult to choose an antidiabetic agent from the available groups which become even more complex by rapidly introducing newer agents. Aims & Objective: To evaluate prescribing pattern of newer oral antidiabetic agents in a tertiary care hospital. Materials and Methods: Prospective observational study was conducted for one year in the diabetic out patient department (OPD) at Civil Hospital, Ahmedabad. A total 290 randomly selected patients of all age groups and either sex of type 2 diabetes mellitus were observed and details were recorded in a predesigned case record form. FBS level of 120mg% and PPBS level of 150 mg% was considered for achieving Results: Among the patients who had undergone blood sugar analysis at the time of study, FBS level was 120 mg% in 48 (22.42%) patients while PPBS level was 150mg% in 21 patients (9.81%) only. Oral antidiabetic drugs alone were prescribed in 242 (83.45%) patients while insulin was added along with oral antidiabetic agents in rest of patients. Among patients receiving oral antidiabetic drugs, monotherapy was prescribed in only 43 (14.83%) patients while in the rest of the patients combination therapy was prescribed. Among oral antidiabetic combination, glipizide along with metformin is the most commonly prescribed combination in 112 (38.42%) patients. Among newer agents, pioglitazone was the most commonly prescribed agent but only in combination with other oral antidiabetic agents. Pioglitazone was prescribed with glipizide and metformin in 44 (15.17%) patients while along with metformin and glimepiride in 10 (3.45%) patients. Patients who had diabetes for five years or less could be managed with single oral agent while two or three agents were required in patients having diabetes for more than this period. Conclusion: Adequate management of diabetes mellitus is difficult to be achieved with a single oral agent. Most of the patients require two or more drugs to achieve glycemic control. Newer antidiabetic agents have been prescribed in combination only. Pioglitazone has been the most frequently prescribed medication in combination with glipizide and metformin. Even with all these medications a tight glycemic control is achieved in very few patients which needs an attention. Source


Patel B.,PDU Government Medical College | Kubavat A.,PDU Government Medical College | Piparva K.,PDU Government Medical College
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2013

Background: Assessment of learning has always been difficult, yet an important part of our education system. Curricular guidelines of Medical Council of India lay emphasis on methods of assessment of knowledge and skills in Pharmacology. Advances in scientific knowledge and innovations in educational field that necessitates constant change in medical curriculum. Aims & Objective: To correlate student's performance in theory and practical of final summative pharmacology examination in M.B.B.S curriculum in order to have a critical insight. Materials and Methods: Present study is a record-based observational study done at PDU Govt. Medical College, Rajkot, Gujarat. We have taken data for six consecutive years from 2007 to 2012. Based on their performance in terms of percentage of marks, all students in a batch were classified into five categories: 'failed' (F) = <50%, 'borderline passed' (BP) = 50 to 55%, 'passed' (P) = >55 to <60 %, 'passed with first class' (PF) = ≥ 60%, 'passed with distinction' (PD) = ≥ 70%. Descriptive statistical analysis includes percentage; Mean, SD and Median were calculated by Microsoft Office Excel 2007. Association between the percentage of marks in theory and practical in each category were assessed by Pearson's correlation coefficient. Data was analyzed by software Graphpad Prism version 6.01. Results: Our study showed that there was a lack of significant association in performance in written and practical examination among students in all Categories in all six batches (P>0.05) except in category 'PF', highly significant association was observed in batches 2010 and 2011. Rather, the poorer performance in theory examination, higher marks were obtained in the practical. Such trend is most prominent in 'F' and 'BP' and 'P' categories of students. Conclusion: The observations of the present study established the subjective nature of both written and practical examination. There is a need for having a relook at the strategies followed in the existing assessment system. Source

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