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Ludhiāna, India

Sekhon B.S.,PCTE Institute of Pharmacy
Current Drug Targets

Supramolecular chemistry enabling molecules and molecular complexes binding through non-covalent bonds allows nanomedicines to serve their desirable function to deliver drugs at the right time and the right place with minimal invasiveness. Supramolecular nanomedicine is the application of nanosupramolecules to the human health and disease and its main applications include diagnosis and therapy, drug and gene delivery, and tissue engineering. Nanoparticles with different structures obtained by assembling supraamphiphiles are promising candidates for multifunctional therapeutic platforms combining imaging and therapeutic capabilities. Encapsulation in supramolecular nanocarriers such as polymeric micelles, polymeric vesciles, layer-by-layer assembly, and porphysomes has the potential to deliver imaging and therapeutic drugs to the sites of action in the body. Hybrid supramolecular nanostructures of organic and inorganic molecules show promising potential in nanomedicine. Research is progressing towards rapid development on supramolecular nanotheranostic devices. Moreover, supramolecular nanoparticles exhibit low-toxicity, low-immunogenicity, nonpathogenicity, and in vivo degradability. © 2015 Bentham Science Publishers. Source

Mahajan M.,Guru Nanak Dev University | Khurana R.K.,Panjab University | Sahajpal N.S.,Guru Nanak Dev University | Utreja P.,PCTE Institute of Pharmacy | And 3 more authors.
Current Drug Metabolism

Taxanes introduction in the mid 90s leads to significant advancement as well as superlative improvement in the treatment of cancer. Since then, several strategies have been designed to enhance therapeutic potential of these agents by overcoming the limitations in drug delivery and pharmacokinetic constraints associated with conventional delivery. In this regard, controlled drug delivery systems for taxanes have contributed enormously by altering the pharmacokinetic profile, thus ultimately enhancing their therapeutic response. With their conferred stellar merits, controlled drug delivery systems have been able to surmount many of the challenges associated with conventional drug delivery systems. The altered absorption, resistance, low toxicity and cellular uptake profiles that lead to better safety from variegated carrier systems like nanocarriers, liposomes, solid lipid nanoparticles, nanoemulsions, nanocapsules, hydrogels and micelles for controlled delivery of taxanes call for an exhaustive review for future progressive work. Therefore, this review focuses on the altered pharmacokinetic, pharmacodynamic and toxicity patterns achieved from various controlled drug delivery approaches, with the latter half highlighting the clinical profile set ups and commercial aspects of controlled release drug delivery systems. © 2015 Bentham Science Publishers. Source

Sekhon B.S.,PCTE Institute of Pharmacy
Current Chemical Biology

Improper allocation of the incorrect metal ion to a metalloprotein can have resounding and often detrimental effects on different aspects of cellular physiology. Enzymes that employ transition metals as co-factors are housed in a wide variety of intracellular locations or are exported to the extracellular milieu. Metallochaperones (much smaller than the cell) are essential for the proper functioning of cells and are a distinct class of proteins which accounts for the incorporation of metal ion cofactors into metalloenzymes / metalloproteins. Metals in the cells are distributed by metallochaperones (intracellular metal ion carriers) and these intracellular metal ion carriers ensure that the correct metal is acquired by a specific metalloenzyme. Metallochaperones act in the intracellular trafficking of metal ions to protect the cell and are a family of soluble metal receptor proteins that bind and protect metal ions/cofactors. The target sites for metal/cofactor delivery include a number of metalloenzymes, or proteins that bind metal ions and use these ions as cofactors to perform essential biochemical reactions such as cellular respiration, DNA synthesis and antioxidant defense. In this review, metallochaperones for various metals such as copper, nickel, zinc, iron, arsenic, manganese, cobalt, molybdenum and vanadium are discussed. In the cell, the specific metal ion is often selected by specific protein-protein interactions between the apoprotein and a metallochaperone and ligand-exchange reactions have been involved in the metal transfer from metallochaperones to cognate apoproteins. The development of chaperone-based medications from medicinal plants has been reported. ©2010 Bentham Science Publishers Ltd. Source

Mahajan M.,Guru Nanak Dev University | Utreja P.,PCTE Institute of Pharmacy | Jain S.K.,Guru Nanak Dev University
Anti-Cancer Agents in Medicinal Chemistry

In an attempt to improve the localized paclitaxel delivery, carrier based thermoresponsive chitosan hydrogel was exploited in the present study. Nanoliposomes as carrier for paclitaxel were prepared and optimized in strength of 6 mg/ml similar to marketed paclitaxel formulation. The chitosan solution (2% w/v) mixed with different concentrations of dibasic sodium phosphate (DSP) was evaluated as thermoresponsive systems in terms of gelling temperature and time. Finally, the drug loaded nanoliposomes were incorporated in optimized chitosan- DSP hydrogel base to form nanoliposomal in situ thermosensitive hydrogel formulations having dual mechanism of protection and release. The optimal formulation containing DSP was selected on the basis of minimal gelation temperature (37±0.8 ºC) and time (6.7±0.3 min). In vitro drug release experiment illustrated that developed formulation manifested sustained release action in which drug release was extended for more than 72 h compared to marketed formulation. In addition, optimized nanoliposomal hydrogel demonstrated enhanced biological half-life of 15.7±1.5h, depicting maintenance of constant plasma concentration in contrast to marketed formulation that showed the half-life (t1/2) of 3.6±0.4h. The in vivo anti tumor activity tested using EAC model also corroborated the above findings that developed formulation was having significant higher anti-tumor activity and reduced toxicity than the marketed formulation. Tumor volume was found to reduce upto 89.1±3.5% by treatment with in situ hydrogel formulation. The histopathological study of tumor also demonstrated the better safety and efficacy of developed formulation in comparison to marketed paclitaxel formulation. Our results suggest that carrier based chitosan hydrogel could be an efficacious vehicle for sustained and localized delivery of paclitaxel. © 2016 Bentham Science Publishers. Source

De A.,PCTE Institute of Pharmacy | Gill A.K.,PCTE Institute of Pharmacy
Journal of Applied Pharmaceutical Science

The objective of the present study was to formulate and evaluate Tretinoin proniosomal gel and to carry out comparative skin irritation study with conventional Tretinoin solution and Tretinoin conventional gel. Topical Tretinoin (0.25%, 0.05%) has been a reliable treatment of acne vulgaris since 30 years but its major drawback is that it causes skin irritation on the applied area. The proniosomal dispersion was prepared using different grades of non-ionic surfactants and cholesterol in different ratios along with Tretinoin. The scanning electron microscopy revealed that the proniosome vesicles were of LUV type and spherical shape. The proniosome vesicles prepared with SPAN 60, 40 and cholesterol in formulation PN9 showed maximum entrapment efficiency (76.77±1.54) .The prepared proniosome vesicles were incorporated into Carbopol gel (1%) base to prepare Tretinoin proniosomal gel. The stability study was carried out at different accelerated and non-accelerated conditions. The In-vitro diffusion study carried out using sigma dialysis membrane showed sustained release pattern of Tretinoin from proniosomal gel formulation. The comparative skin irritation study carried out on 18 healthy Wistar Rats of either sex showed remarkable decrease in signs of skin irritation caused by Tretinoin. Source

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