PCTE Group of Institutes

Ludhiāna, India

PCTE Group of Institutes

Ludhiāna, India
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Thakur S.,PCTE Group of Institutes | Srivastava N.,PCTE Group of Institutes
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2016

An rodent animal model of pain offers a powerful tool in order to understand the mechanism involved in peripheral nerve injury for preclinical study of pain. A battery of neuropathic pain models has been developed to simulate the clinical pain conditions with diverse etiology. This article reviews some of the most widely used or promising new models for chronic pain. Partial spinal ligation, chronic constriction injury, and L5/l6 spinal nerve ligation represent three of the best-characterized rodent models of peripheral neuropathy. For reasons of reproducibility and simplicity, most studies of neuropathic pain are based upon animal models of traumatic nerve injury, usually in the rat sciatic nerve. The present review exhaustively discusses the methodology, behavioral alterations of different animal models of neuropathic pain along with their modifications. Development of these models has contributed immensely in understanding the chronic pain and underlying peripheral as well as central pathogenic mechanisms. © 2016 The Authors.


Saluja V.,PCTE Group of Institutes | Singh A.,PCTE Group of Institutes | Algradi A.M.,PCTE Group of Institutes
Current Pharmaceutical Design | Year: 2016

The regulatory paradigm is relaxing gradually without compromising the safety, efficacy and the quality of the drug product and, most importantly, a perceptible scientific consensus is maturing towards the need of affordable medicines. The establishment of bioequivalence (BE) is no longer being considered to be accomplished only by in vivo studies in oral drug products. The potential use of in vitro dissolution testing in lieu of BE studies has now been regulatory adopted and is commonly referred to as “biowaiver”. Further, the advent of biopharmaceutics classification system (BCS) and in vitro-in vivo correlation (IVIVC) proves to be sound milestones and signifies that we are incessantly forwarding towards a scenario that would reduce regulatory burden, save time and make the drug products more affordable while ensuring their quality. This review outlines, the current and pertinent regulatory environment for biowaiver based on in vitro drug dissolution, primarily as per the FDA perspective. The rationale used for qualification of biowaiver for different strengths, post-approval changes and multi-source products are discussed along with the role of BCS and IVIVC. © 2016 Bentham Science Publishers.


Patle D.,PCTE Group of Institutes
Current Trends in Biotechnology and Pharmacy | Year: 2016

The aim of the study is to develop and validate a simple, precise and rapid high performance thin layer chromatographic (HPTLC) method for Cefpodoxime Proxetil and Ofloxacin in bulk and combined tablet dosage form. Chromatographic separation was accomplished by using precoated silica gel 60F254 TLC plate (20cm × 10cm) with 250µm thickness with mobile phase Chloroform in ratio methanol (9:1 v/v). Detection was performed at isobestic point 255 nm for both drugs. The retesion factor of Cefpodoxime Proxetil and Ofloxacin were found to be 0.63 and 0.25, respectively. The reliability of the method was assessed by evaluation of linearity range (500-3000 ng/spot for both Cefpodoxime proxetil and ofloxacin respectively. Accuracy (99.56 % for Cefpodoxime Proxetil and 99.33% for Ofloxacin), and specificity, in compliance with ICH guidelines. © 2017 Association of Biotechnology and Pharmacy. All Rights Reserved.


Thakur S.,PCTE Group of Institutes | Srivastava N.,PCTE Group of Institutes
Current Trends in Biotechnology and Pharmacy | Year: 2017

Peroxisome proliferator-activated receptors (PPARs) are ligand activated transcription factors that modulate target gene expression in response to endogenous and exogenous ligands. Peroxisome proliferator-activated receptors are expressed in many tissues, including adipocytes, hepatocytes, muscles and endothelial cells. The PPARs, a family of nuclear receptors (NRs), are a set of three receptor sub-types encoded by distinct genes. The discovery of PPAR-specific ligands has led to a significant advancement in our understanding of the structure of these receptor proteins and molecular mechanisms of their ligand dependent activation. The nuclear receptor peroxisome proliferator-activated receptor (PPAR)-γ is a crucial cellular and metabolic switch that regulates many physiologic and disease processes. © 2017, Association of Biotechnology and Pharmacy. All rights reserved.


Grover M.,PCTE Group of Institutes | Utreja P.,PCTE Group of Institutes
Current Drug Delivery | Year: 2014

Almost 200 million people worldwide are found to be affected by Diabetes mellitus (DM). DM is a metabolic disorder which occurs due to reduced insulin action and/or insulin secretion in the body. Reduced or inactive insulin results in imbalanced food metabolism. With the progression of disease, pathological changes like nephropathy, retinopathy and cardiovascular complications start occurring in the body. DM is mainly categorized into 2 types: type 1 DM and type 2 DM. Type 1 is generally treated through insulin replacement therapy. Type 2 DM is treated with oral hypoglycemics. Oral hypoglycemics are classified into 5 types: sulfonylureas, biguanides, α-glucosidase inhibitors, meglitinide analogues and thiazolidinediones. Conventional dosage forms of most of these drugs bear some drawbacks such as frequent dosing, short half live, and low bioavailability. Therefore, to alleviate the drawbacks associated with conventional dosage forms, efforts have been made in the area of novel and controlled drug delivery system for oral hypoglycemics. Present review highlights various novel and controlled drug delivery systems that have been investigated by different researchers for achieving sustained and controlled drug delivery of oral hypoglycemics and for overcoming the limitations related with the conventional dosage forms of oral hypoglycemics. © 2014 Bentham Science Publishers.


Saluja V.,PCTE Group of Institutes | Sekhon B.S.,PCTE Group of Institutes
Journal of Excipients and Food Chemicals | Year: 2014

Pharmaceutical excipients are vital components of drug formulations and are generally considered pharmacologically inert. Control of excipient manufacturing and distribution is now considered a key priority by regulatory authorities and pharmaceutical manufacturers, because adulteration of pharmaceutical excipients has resulted in adverse effects in patients. Furthermore, with the emergence of novel excipients and delivery systems, better quality and supply control of pharmaceutical excipients becomes increasingly important in the context of in vivo performance. Recognizing the critical role that excipients play in pharmaceutical dosage forms necessitates that excipient suppliers meet the quality requirements of the pharmaceutical industry and the pharmaceutical industry as a whole must work to assume integrity of the supply chain. © IPEC-Americas Inc.


Gulati M.,Lovely Professional University | Chopra D.S.,Punjabi University | Singh S.K.,Lovely Professional University | Saluja V.,PCTE Group of Institutes | And 2 more authors.
Recent Patents on CNS Drug Discovery | Year: 2013

The blood-brain barrier (BBB) presents a combination of physical and electrostatic barriers. It is a highly complex structure that tightly regulates the movement of molecules from the blood to brain, protecting it from injuries and diseases. However, the BBB also significantly precludes the delivery of drugs to the brain, thus, preventing the therapy of a number of neurological disorders like brain cancer, epilepsy, Alzheimer's disease, schizophrenia etc. Numerous drug delivery strategies have been developed to circumvent this barrier. Out of those, one popular approach is the use of nanoparticles. Nanoparticles form solid, colloidal drug delivery system that consists of macromolecular materials in which the active principle is dissolved, entrapped or encapsulated or onto which the active principle is adsorbed or attached. Brain targeted polymeric nanoparticles have been found to increase the therapeutic efficacy and reduce the toxicity for a large number of drugs. By coating the nanoparticles with surfactants, higher concentrations of the drugs can be delivered. The article presents various approaches used in design and delivery of nanoparticles to brain. It also reviews various patents that describe the use of nanoparticles to deliver various neurotherapeutics to brain. © 2013 Bentham Science Publishers.


PubMed | PCTE Group of Institutes
Type: | Journal: Current pharmaceutical design | Year: 2016

The regulatory paradigm is relaxing gradually without compromising the safety, efficacy and the quality of the product and, most importantly, a perceptible scientific consensus is maturing towards the need of affordable medicines. The establishment of bioequivalence (BE) is no longer being considered to be accomplished only by in vivo studies in oral drug products. The potential use of in vitro dissolution testing in lieu of BE studies has now been regulatory adopted and is commonly referred to as biowaiver. Further, the advent of biopharmaceutics classification system (BCS) and in vitro-in vivo correlation (IVIVC) proves to be sound milestones and signifies that we are incessantly forwarding towards a scenario that would reduce regulatory burden, save time and make the drug products more affordable while insuring their quality. This review outlines, the current and pertinent regulatory environment for biowaiver based on in vitro drug dissolution, primarily as per the FDA prospective. The rationale used for qualification of biowaiver for different strengths, post-approval changes and multi-source products are discussed along with the role of BCS and IVIVC.


PubMed | PCTE Group of Institutes
Type: Journal Article | Journal: Current drug delivery | Year: 2015

An important step in oral drug development is to identify drug candidates that show sufficient aqueous solubility and could resist or bypass first-pass metabolism in order to overcome bioavailability problems. Aqueous solubility is characteristically low for Biopharmaceutical Classification System (BCS) class II and class IV drug candidates. Several formulation approaches are being identified to overcome the low solubility aspect of a drug candidate such as particle size manipulation, solid dispersions, inclusion complexes and several of nanoparticle-based options. However, the formulation for drug candidates that in addition to low aqueous solubility shows high intestinal and first-pass metabolism is challenging. The self-emulsifying lipid formulations (SELF) provide a mean for sidestepping these factors and improve the bioavailability of lipophilic and highly first- pass metabolised drugs. Nevertheless, formulation of a successful SELF requires an exhaustive understanding of the component used to formulate them, the behaviour of the formulation within the gastrointestinal (GI) milieu and the mechanism by which the drug is released and absorbed. This review gives a brief description of the formulation aspects of SELF and their potential role to mitigate the bioavailability problem related to lipophilic and highly first- pass metabolised drugs.


PubMed | Jadavpur University and PCTE Group of Institutes
Type: Journal Article | Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer | Year: 2016

The present study evaluates the protective potential of the flavonoid naringenin (NRG) against experimentally induced cadmium (Cd) toxicity in Swiss albino mice. NRG (4 and 8 mg/kg) was orally administered to mice 30 min before oral administration of CdCl2 (12 mg/kg) for 11 consecutive days. On the 12th day, we evaluated body and organ weights, hematological profiles, serum biochemical profiles, and hepatic and renal tissue antioxidative parameters including lipid peroxidation, reduced and oxidized glutathione, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, superoxide dismutase, and catalase. Cotreatment with NRG markedly and significantly normalized body and organ weights, hematological profiles, and serum biochemical profiles and significantly modulated all of the hepatic and renal tissue biochemical parameters in Cd-intoxicated mice. The present findings show that NRG possesses a remarkable alleviative effect against Cd-induced toxicity in albino mice, mediated by abrogation of Cd-induced oxidative stress by multiple mechanisms.

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