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Abbas S.,Abasyn University | Hussain A.,University of Peshawar | Mateen A.,Abasyn University | Ali J.,PCSIR Laboratories Complex Peshawar | And 3 more authors.
Life Science Journal | Year: 2013

During this clinical pharmacy clerkship in pediatric ward-A (Lady Reading Hospital) the studied diseases include GIT abnormalities (Enteric fever, diarrhea, Constipation)and hepatic abnormalities (Ascites, Liver abscess, hepatomegaly) along with other complications (Celia, upper GIT bleeding). During the said period I focused on, Etiology, Pathophysiology, sign and symptoms, diagnosis and pharmacotherapy of these ailments. Collection of case histories was the 1st priority of all considerations. The collected histories comprises mainly of patient demographics, chief complaints, principal diagnosis and laboratory tests, medications used in hospital and others. The collected data was analyzed regarding the drug therapy at hospital, its dosage in different age groups and their respective physical conditions and a comparative analysis was also done i.e. comparing therapy given at hospital and that recommended by standard therapeutic guidelines. The major parameters considered and studied were drug related problems. The overall prognosis of the disease was also observed. The major discrepancies that ensue during drug therapy at hospital were drug selection, dose calculation, dose adjustment and drug interactions. Medications prescribed at hospital in certain cases showed deviation from standard therapy recommended, a brief discussion of which and its impact upon prognosis and recommendations for the management of such problems is also considered.

Ahmad B.,University of Peshawar | Ashiq S.,University of Peshawar | Hussain A.,PCSIR Laboratories Complex Peshawar | Bashir S.,University of Peshawar | Hussain M.,Kohat University of Science and Technology
Fungal Biology | Year: 2014

Medicinal plants are used worldwide to treat a variety of ailments. Due to the provenance of medicinal plants, they are subjected to contamination by moulds, which may be responsible for spoilage and production of mycotoxins. The investigation was designed to throw light on mycological and mycotoxicological status of some medicinal plants from Pakistan and the result showed 30 % and 26.7 % samples were contaminated with aflatoxins and ochratoxin A, respectively. Mould contamination was present in 90 % samples, of which 70 % exceeded the permissible limits. Opium poppy, licorice root, and Indian rennet were most contaminated samples. The predominant moulds found were Aspergillus flavus, Aspergillus niger, Aspergillus parasiticus, and Penicillium spp. and 31 % of the 47 isolates tested were found to be toxigenic. The findings indicate that the contamination in the medicinal plants may contribute to adverse human health problems. This information would prove helpful for regulatory agencies to establish limits for these contaminants in medicinal plants and will explore ways for export of herbal products to countries where more stringent permissible limits of mycotoxins exist. The study is first of its kind in the country reporting natural occurrence of mycotoxins in medicinal plants in Pakistan. © 2014 The British Mycological Society.

Ahmad B.,University of Peshawar | Muhammad S.,University of Peshawar | Ali J.,PCSIR Laboratories Complex Peshawar | Ali I.,Nuclear Institute for Food and Agriculture Peshawar
Life Science Journal | Year: 2013

Information about the genetic variability and the extent and type of relationship of some quantitative characters in rapeseed is important for an efficient breeding program. Thirty five advance brassica mutant lines and one check were evaluated for genetic variability between days to 50% flowering, plant height (cm), 1000 seed weight (g), seed yield (kg ha-1) and oil yield (kg ha-1) during 2008-09. The mutant lines and the check were sown in four replications using Randomized Complete Block Design (RCBD). The research experiment was conducted during 2008-09 at Nuclear Institute for Food and Agriculture (NIFA) Peshawar. High genetic variability were recorded for oil yield, seed yield and number of days to flowering which demonstrated the effect of environment for the inheritance of these characters. Heritability and genetic advance were recorded high for oil yield and seed yield showing the existence of additive gene action for the expression of these traits. In order to increase oil yield selection based on seed yield would be more effective. More over all the traits showed sufficient variability in the tested mutant lines however, the mutant lines OA5, G1 and O6 were superior having high seed yield, oil yield and 1000 seed weight and also early in flowering.

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