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Camarillo, CA, United States

Patent
PBS Biotech Inc. | Date: 2010-03-19

An aseptic sampling system includes substantially sealed sampling lines connecting one or more sample container to a vessel containing the fluid to be sampled. A flow control system includes valves and/or clamps placed strategically along the sampling lines and filtered vent lines are provided at strategic locations relative to a reversible fluid pump in communication with the sampling lines. The clamps are selectively actuated, the vent lines are selectively opened or closed, and the pump is operated in a forward or reverse direction to permit a volume of sample fluid to be drawn from the vessel and into a sample container and to permit fluid to be purged from the sampling lines either into the sample container or back into the vessel. Thus, sampling and purging can be accomplished without opening the system to potentially contaminating agents and without wasting or having to properly dispose the fluid.


Trademark
PBS Biotech Inc. | Date: 2010-01-19

Bioreactors for cell culturing; Computer hardware for bioreactors; Software for use in connection with bioreactors which controls and monitors cell culture process parameters, records data, alerts the user to alarms, logs events, and runs process recipes and safety interlocks; Computer hardware and software parts for bioreactors, namely, memory cards, microchips and microprocessors.


Trademark
PBS Biotech Inc. | Date: 2010-01-19

Bioreactors; hardware and software and their parts related to bioreactors.


Patent
PBS Biotech Inc. | Date: 2014-12-22

A bioreactor includes a vessel containing a fluid to be mixed and at least one mixing device driven by a non-contaminating, indirect drive system. The mixing speed of the mixing device inside of the bioreactor may be controlled by the rotating speed of the magnets or the frequency of polarity changes of electromagnets outside the vessel acting upon magnets or ferrous material in or on the impeller wheel. The impeller wheel has a plurality of radially-oriented outer paddles with gaps therebetween that mixes fluid and culture cells around the vessel. A pair of curved axial flow vanes toward the middle of the impeller wheel washes the culture mix further.


Patent
PBS Biotech Inc. | Date: 2010-09-17

A pneumatic bioreactor includes a vessel containing a fluid to be mixed and at least one mixing device driven by gas pressure. A first embodiment includes a floating impeller that rises and falls in the fluid as gas bubbles carry it upward to the surface where the gas is then vented, permitting the impeller to sink in the fluid. The floating impeller may be tethered to a second impeller with a flexible member and pulley. The mixing speed is controlled with electromagnets in the vessel acting upon magnetic material in the impeller or its guides. In another embodiment, floating pistons mix the fluid, pushing it through a mixing plate with one or more apertures. In a third embodiment, the mixing device is a rotating drum with bubble-catching blades and rotating mixing plates with apertures. The top of the vessel for these mixers may include a closed top and sterile filters.

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