Ostovan F.,Payamnoor University |
Olomi H.,Kerman Graduate University of Technology |
Gol A.,Shahid Bahonar University of Kerman
Physiology and Pharmacology | Year: 2014
Introduction: Diabetes mellitus is a metabolic disorder and it is estimated that its annual incidence rate will continue to increase in the future worldwide. Increased oxidant factors and decreased antioxidant defense are two of the factors resulting in diabetes. In the present study, we aimed to investigate Citrullus Colocynthis pulp effects on oxidant and antioxidant factors of liver in streptozotocin-induced diabetic rats. Methods: Thirty-two male rats were divided into four groups eight each: N (normal) group, N+C group, D (diabetic) group, and D+C group. Groups N and D received normal saline 2ml orally for 2 weeks and Groups N+C and D+C received 10mg/kg Citrullus Colocynthis pulp orally for 2 weeks. Diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ) at 65 mg/kg. Results: Diabetic group had a significant increase in H2O2 (Hydrogen peroxide), MDA (malondialdehyde) and CAT (catalase) activity and a significant decrease in POD (peroxidase) activity in liver tissues compared to N and D groups. Group D+C had a significant decrease in H2O2, MDA, and CAT concentrations in liver tissues and significant increase in POD activity in liver tissues compared to D group. Conclusion: These results suggest that treatment of diabetic rats with Citrullus colocynthis pulp decreased oxidant stress and support antioxidant defense in liver STZ-Induced diabetic rats.
PubMed | Arak University of Medical Sciences, Payamnoor University, Research Institute for Pulmonology and Phthisiology, Payame Noor University and Belarusian Research Institute for Epidemiology and Microbiology
Type: Journal Article | Journal: International journal of mycobacteriology | Year: 2016
A descriptive study of drug-resistance patterns by age group and among culture-positive pulmonary tuberculosis (TB) patients referred to the Research Institute for Pulmonology and Phthisiology of Belarus between January 2007 and January 2008.Drug susceptibility tests were performed for first- and second-line anti-tuberculosis drugs. Patients were clustered into five resistance categories: mono-resistant (Mono); multi-drug resistant (MDR); all first-line drug resistance (MDR+ES); and extensively drug resistant (XDR). The patients were divided into primary and secondary and into six groups based on age in years (<15, 15-24, 25-44, 45-54, 55-65, and >65).An analysis was undertaken of information gathered from 934TB patients, of whom 660 were men (70.671.5%) and 274 were women (29.331.5%) (p<0.001). In the age group 25-65years, men outnumbered women between 2.7 and 9.0 times higher. Cases of secondary TB totaled 414 (52.021.77%), and primary cases totaled 382 (47.981.77%) (p>0.05); 756 of the patients were of working age, and 170 were of non-working age, of whom 570 men of working age (18-60years) and 188 women of working age (18-55years) participated. Males were significantly more likely to have MDR-TB than females. All cases with XDR-TB were older than 14years old.As Belarus is a high-burden MDR-TB country and treatment of drug-resistant TB is long and complicated, the findings of this study provided useful information to deliver effective community-based disease control measures and a proposed plane for the effective management of drug-resistant TB at the national level.
Yari Fard R.,Wuhan University of Technology |
Maleki S.E.,Islamic Azad University at Tehran |
Bakhshian A.,PayamNoor University |
Fard S.Y.,Islamic Azad University at Tehran
Advances in Environmental Biology | Year: 2013
The transition from traditional society to industrial and transformation of national economies into the international economy requires a variety of tactics in order to facilitate economic growth and development in the society. Entrepreneurship and creativity are considered cornerstones of this fundamental transition. Steady economic growth which leads to international prestige and recognition could only be obtained through accurate planning and development of Entrepreneurship. Entrepreneurship is the most important source for innovation, job opportunities and development. Entrepreneurship is one of the major factors of economic growth and development besides capital and manpower, which requires creative and innovative Entrepreneurs. Encouraging Entrepreneurship attitude in the society and training motivated Entrepreneurs has a positive effect on social and economic development, for Entrepreneurs improve the overall performance of business units and enterprises through optimum utilization of resources and creation of job opportunities. This article studies the concept of Entrepreneurship in order to analyses the need for its development and application in the society in an attempt to describe its role in the social and economic growth of a nation as well as its advantages and disadvantages. © 2013 AENSI Publisher All rights reserved.
Sedighi M.,Avicenna Research Institute |
Aledavood S.A.,Mashhad University of Medical Sciences |
Abbaszadegan M.R.,Avicenna Research Institute |
Memar B.,Mashhad University of Medical Sciences |
And 3 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2016
Background: Matric metalloproteinase (MMP) 13 gene expression is increased in esophageal squamous cell carcinomas (ESCCs) and associated with increasing tumor invasion, lymph node involvement and decreased survival rates. Levels of the circulating enzyme may be elevated and used as a marker of tumor progression. In this study, clinical application of MMP-13 serum levels was evaluated for early detection, prediction of prognosis and survival time of ESCC patients. Materials and Methods: Serum levels of MMP13 were determined by ELISA in 66 ESCC patients prior of any treatment and 54 healthy controls for comparison with clinicopathological data through statistical analysis with Man Whitney U and Log-Rank tests. In addition, clinical value of MMP13 levels for diagnosis was evaluated by receiver operating characteristic (ROC) test. Results: The serum level of MMP-13 in patients (>250 pg/ml) was significantly higher than in the control group (<100 pg/ml) (p value=0.004). Also the results showed a significant correlation between MMP-13 serum levels with tumor stage (p value = 0.003), depth of tumor invasion (p value=0.008), involvement of lymph nodes (p value = 0.011), tumor size (p value = 0.018) and survival time. While there were no significant correlation with grade and location of tumors. ROC analysis showed that MMP-13 level is an accurate diagnostic marker especially to differentiate pre-invasive/invasive lesions from normal controls (sensitivity and specificity: 100%). Conclusions: These findings indicate a potential clinical significance of serum MMP13 measurement for early detection and prognostic assessment in ESCC patients.
Hakimelahi R.,Islamic Azad University at Jahrom |
Hakimelahi R.,Payamnoor University |
Nasehi P.,Islamic Azad University |
Nasehi P.,Payamnoor University |
And 2 more authors.
Der Pharma Chemica | Year: 2015
In this work carrier-facilitated transport of mercury(II) against its concentration gradient from aqueous 0.04 M hydrochloric acid solution across a liquid membrane containing 2-(4-Choloro Phenyl) - 2,3 Di Hydro Qinazoline (1- H) - 4 one (CPHQO) as the mobile carrier in chloroform has been investigated. Sodium thiocyanate solution (1.6 M) was the most efficient receiving phase agent among several aqueous reagents tested. Various parameters such as investigated. Under optimum conditions the transport of Hg(II) across the liquid membrane is more than 97% after 2.5 h. The carrier, BHIS, selectively and efficiently could able to transport Hg (II) ions in the presence of other associated metal ions in binary system.
Kahkhaie K.R.,Payamnoor University |
Kahkhaie K.R.,Zabol University of Medical Sciences |
Moaven O.,Harvard University |
Abbaszadegan M.R.,Mashhad University of Medical Sciences |
And 2 more authors.
World Journal of Surgery | Year: 2014
Background: Mucin 1 (MUC1) is a complex glycoprotein expressed on the apical surface of normal glandular epithelial cells. It plays a role in a number of biologic processes, and its overexpression is associated with various malignancies. A growing body of literature suggests that MUC1 is a potential diagnostic and therapeutic marker. Increasing numbers of variants are being identified for the MUC1 gene, but their role in carcinogenesis is unclear. Alternative splicing and a specific region on a variable number of tandem repeats are characteristic features of MUC1. However, the underlying mechanisms, overall prevalence, and the function of various MUC1 isoforms are not well characterized. Methods: In the present study, mRNA expression of nine variants of the MUC1 gene (A-D, X-Z, REP, SEC) was evaluated in normal and tumor tissues obtained from 50 patients with esophageal squamous cell carcinoma (ESCC). Associations between expression of various isoforms of MUC1 and important clinicopathologic factors were studied. Results: Specific MUC1 splice variants (i.e., MUC1/C, D, and Z) are correlated with tumor progression in ESCC, whereas MUC1/B - previously suggested as a "normal" variant in some other cancers - has protective effects and is associated with more favorable tumor behavior and better prognosis. Conclusions: Specific isoforms of ESCC are associated with prognosis. Further characterization of different isoforms of MUC1 and their biologic effects is needed to explore their diagnostic and prognostic potential in clinical practice. © 2014 Société Internationale de Chirurgie.
Amouzad Khalili M.,Payamnoor University |
Mohsen Abbarin S.,Payamnoor University
Life Science Journal | Year: 2012
Knowledge sharing is of vital importance to organizations, enabling them to develop skills and competences, increase value, and sustain their competitive advantage. Knowledge is a firm's most valuable resource because it embodies intangible assets, routines, and creative processes that are difficult to imitate. Thus in this study we have investigated the role of Knowledge sharing as facilitator Intellectual capital management of emoloyees in the organizations. This study mainly probes Knowledge sharing as a tool which is able to manage, store, and transmit structural knowledge. It can support us in our efforts to make the knowledge stored in the human brain or in documents available to all employees of an organization. Also we present Intellectual capital management for convenient knowledge sharing as a successful case studies in management.
Fatemi R.,Islamic Azad University |
Javid M.,Islamic Azad University |
Najafabadi E.M.,Payamnoor University
Journal of Back and Musculoskeletal Rehabilitation | Year: 2015
BACKGROUND: There are many types of treatments and recommendations for restoring back deformities depending on doctors' knowledge and opinions. The purpose of the exercises is to reduce pain and to ensure stability of the lower trunk by toning the abdominal muscles, buttocks and hamstrings. Given the duration of flares and relapses rate, it is important to apply an efficient and lasting treatment. OBJECTIVE: To evaluate the effects of 8 weeks of William's training on flexibility of lumbosacral muscles and lumbar angle in females with Hyperlordosis. METHODS: Forty female students with lumbar lordosis more than normal degrees (Hyperlordotic) that were randomly divided into exercise and control groups were selected as the study sample. The lumbar lordosis was measured using a flexible ruler, flexibility of hamstring muscles was measured with the active knee extension test, the hip flexor muscles strength was measured using Thomas test, the lumbar muscles flexibility measures by Schober test, abdominal muscles strength measured by Sit-Up test and back pain was measured using McGill's Visual Analogue Scales (VAS) questionnaire. Data were compared before and post-test using independent and paired t-testes. RESULTS: Results showed that 8 weeks of William's exercise led to significant decreases in lumbar angle and back pain, increases in flexibility of hamstring muscles, hip flexor muscles flexibility, lumbar extensor muscles flexibility and abdominal muscles strength. CONCLUSION: The findings show that William's corrective training can be considered as a useful and valid method for restoring and refining back deformities like as accentuated back-arc and became wreaked muscles' performance in lumbar areas. © 2015 - IOS Press and the authors. All rights reserved.
Mombeni H.A.,Polytechnic University of Mozambique |
Rezaei S.,Polytechnic University of Mozambique |
Nadarajah S.,University of Manchester |
Emami M.,Payamnoor University
Water Resources | Year: 2015
There are several methods for saving water, and pricing is one of these methods. The Iranian government implemented targeted subsidies in 2010. According to this plan some basic items like water subsidies were eliminated. In this note we examine the effects of the plan on reducing water use. We have used the time series model, SARIMA, to model water use before targeted subsidies. We predicted water consumption for months after the targeted subsidy plan. We used the Wilcoxon sign rank test for comparison of estimated and actual amounts of water for a period after targeted subsidies. We concluded at 1% significance level that targeted subsidies have reduced domestic water consumption. © 2015, Pleiades Publishing, Ltd.
PubMed | Payamnoor University and Islamic Azad University
Type: Journal Article | Journal: Journal of back and musculoskeletal rehabilitation | Year: 2015
There are many types of treatments and recommendations for restoring back deformities depending on doctors knowledge and opinions. The purpose of the exercises is to reduce pain and to ensure stability of the lower trunk by toning the abdominal muscles, buttocks and hamstrings. Given the duration of flares and relapses rate, it is important to apply an efficient and lasting treatment.To evaluate the effects of 8 weeks of Williams training on flexibility of lumbosacral muscles and lumbar angle in females with Hyperlordosis.Forty female students with lumbar lordosis more than normal degrees (Hyperlordotic) that were randomly divided into exercise and control groups were selected as the study sample. The lumbar lordosis was measured using a flexible ruler, flexibility of hamstring muscles was measured with the active knee extension test, the hip flexor muscles strength was measured using Thomas test, the lumbar muscles flexibility measures by Schober test, abdominal muscles strength measured by Sit-Up test and back pain was measured using McGills Visual Analogue Scales (VAS) questionnaire. Data were compared before and post-test using independent and paired t-testes.Results showed that 8 weeks of Williams exercise led to significant decreases in lumbar angle and back pain, increases in flexibility of hamstring muscles, hip flexor muscles flexibility, lumbar extensor muscles flexibility and abdominal muscles strength.The findings show that Williams corrective training can be considered as a useful and valid method for restoring and refining back deformities like as accentuated back-arc and became wreaked muscles performance in lumbar areas.