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Abbasnejad E.,Education 3rd District Mashhad | Farahani A.,University of Tehran | Nakhaei A.,Payam Noor University of Mashhad
Advances in Environmental Biology | Year: 2013

The present study was carried out to investigate about the relationship between time management and jobrelated stress. For this purpose, 625 teachers working in the education department of Mashhad were selected as samples. These subjects filled time management questionnaire with reliability of 0.86, and job stress questionnaire with reliability of 0.74. Results of Kolmogorov-Smirnov test, Pearson correlation test, 2-string Spirman test, t-test and Mann-Whitney U test showed that: - There is a difference between time management in physical and non-physical education teachers, but it's not a significant difference. Time management of non-PE teachers is higher. - There is a difference between job stress of PE and non-PE teachers, but it's not a significant difference. Job stress of PE teachers is higher than of the other group. - There is a significant but inverse relationship between time management and job stress. - There is no significant relationship between job stress and age, gender, work experience and education level in non-physical education teachers. - There is a direct and significant relationship between time management and age and work experience (in contrast with gender and education level) in PE and non-PE teachers. Source


Mombeinipour M.,Payam Noor University of Mashhad
Archives of Iranian medicine | Year: 2013

Agiogenesis is the development of new blood vessels from pre-existing vasculatures. Although essential in the physiological process, it becomes pathological in various diseases including cancer. Preventing the formation of new blood vessels causes reductions in tumor size and metastasis. This study has been undertaken to elucidate the anti-angiogenesis effects of ICD-85 (derived peptides from venom). We evaluated the ICD-85 anti-angiogenesis activity by the in vivo CAM assay and in vitro tube formation assay of human umbilical vein endothelial cells (HUVECs). The anti-proliferative activity of ICD-85 was also determined through MTT assay on HUVECs. Results of this study revealed the anti-proliferative activity of ICD-85 on the HUVEC cell line with an IC50 of 12 μg/mL. The in vivo CAM assay also clearly showed the prevention of new vascular formation when the chick embryos were exposed to 0.15 μg/disc of ICD-85. In vitro tube formation assay of HUVECs also showed the complete prevention of capillary tube formation on 18 μg/mL. Based on the results obtained in this study, ICD-85 has anti-angiogenesis activity as shown by the prevention of capillary tube formation and the CAM assay. Source


Jamialahmadi K.,Mashhad University of Medical Sciences | Sadeghnia H.R.,Mashhad University of Medical Sciences | Mohammadi G.,Payam Noor University of Mashhad | Kazemabad A.M.,Islamic Azad University at Tehran | Hosseini M.,Mashhad University of Medical Sciences
Pathophysiology | Year: 2013

Introduction and objective: Beneficial effects of glucosamine in spatial learning and memory impairment induced by scopolamine has been evaluated in rats by using Morris water maze. Methods: Male Wistar rats were randomly divided into control, scopolamine and scopolamine plus glucosamine groups. All injections were given in 5 consecutive days and 30. min after each injection, the rats were tested in the Morris water maze test. Escape latency and path length to reach the hidden platform were subjected to analysis of variance [ANOVA]. Results: The rats treated with scopolamine showed increased escape latency and path length to reach the hidden platform compared to control group (P< 0.001). Both escape latency and traveled path length to reach the hidden platform in glucosamine treated animals (1 and 2. g/kg) were significantly lower (P< 0.05 to P<. 0.001) than in the scopolamine group. Conclusion: The results of this study showed that the glucosamine can inhibit scopolamine-induced impairments of spatial learning and memory in rats. Glucosamine might offer a promise in either the prevention or the treatment of neurodegenerative diseases such as Alzheimer's disease. © 2013 Elsevier Ireland Ltd. Source


Malvandi A.M.,Payam Noor University of Mashhad | Malvandi A.M.,Royan Institute for Stem Cell Biology and Technology | Mehrzad J.,Ferdowsi University of Mashhad | Moghaddam M.S.,Payam Noor University of Mashhad
Iranian Journal of Basic Medical Sciences | Year: 2011

Objective(s): Pattern recognition receptors (PRRs) are the main part in the innate immune response. Human glioblastoma cell line (U87-MG) is an established adherent cell line model of this common cancer; due to genetic variations between individuals it is likely more suitable for investigating molecular aspects of innate immunity. Therefore, we undertook a novel characterization of the immune phenotype of U87-MG toward establishing a base for future researches. Materials and Methods: In this study, U87-MG cells where cultured in a normal condition, to investigate levels of toll-like receptor 2 (TLR2), TLR4, myeloid differentiation factor-88 (MyD88) and CD14 transcripts expression in these cells. Both RT-PCR and qPCR were applied to detect and quantify the expression levels of these genes in U87-MG cells and compare them to their levels in the peripheral blood mononuclear cells (PBMC) of healthy individuals, as a common reference. Results: Expression level of TLR2 and TLR4 are not significantly different in U87-MG cells in comparison to PBMC. Also, expression levels of MyD88 and CD14 in U87-MG cells are significantly lower than their levels in PBMC. Furthermore, expression levels of MyD88 and CD14 in both PBMC and U87-MG are significantly lower than TLR2 and TLR4 transcripts. Conclusion: The data reveal expression of TLR4, CD14, MyD88 and TLR2 genes in U87-MG cell line, for the first time. Expression detection of these genes in human glioblastoma cell line might have a potential for diagnosis of inflammatory mechanisms in immune mediated disorders of in vitro models of human brain inflammatory disease. Source


Abbasnejad E.,Education 3rd District Mashhad | Farahani A.,University of Tehran | Nakhaei A.,Payam Noor University of Mashhad
Advances in Environmental Biology | Year: 2013

The Present research was conducted to study the relationship between emotional intelligence and job stress. To this end, 89 teachers of physical education teachers and 89 teachers of non-physical education teachers were selected by class sampling. The subjects completed Shring's emotional intelligence questionnaire (0.81 validity) and Hell Rich and John's job stress questionnaire (0.84 validity). Data obtained from this study was analyzed by using Pearson correlation method, Spearman, two cluster correlation coefficient of Kolmogorov-Smirnov test to determine the normality of variables and independent t- test. Results showed that: -There is a significant but inverse relationship between emotional intelligence and job stress. -There is a significant difference between job stress of physical education teachers and non- physical education teachers and non- physical education teachers' stress is higher. -There is no significant relation between individual characteristics and teachers' emotional intelligence -There is no significant relation between individual characteristics and teachers' job stress and results suggest that there is a significant relation only between gender and job stress and male teachers' job stress is higher. Source

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