Patna Medical College and Hospital
Patna Medical College and Hospital
Jha V.N.,Institute of Human Behaviour and Allied science |
Singh P.K.,Patna Medical College and Hospital
Indian Journal of Pharmacology | Year: 2017
Dissociative convulsions or pseudoseizures are a difficult to treat common psychiatric condition. In a subset of these patients, the chief complaint is clenching of teeth with apparent nonresponsiveness alone. Neither drugs nor psychotherapeutic interventions have been found to be of much help in its management. Report of two such subsets of cases is presented, in which patients with dissociative convulsions showed sudden, dramatic, and sustained good response to the addition of a muscle relaxant eperisone. © 2017 Indian Journal of Pharmacology Published by Wolters Kluwer - Medknow.
Kumari B.,Vardhman Institute of Medical science |
Kumar P.,Darbhanga Medical College and Hospital |
Chaudhary R.K.P.,Patna Medical College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2017
Introduction: Anti-Cyclic Citrullinated Peptides (CCPs) are a well known diagnostic and prognostic noble marker for rheumatoid arthritis. C-Reactive Protein (CRP) is an acute phase protein whose level rises in response to inflammation. Aim: This study was undertaken to show the role of the two markers (anti-CCPs and CRP) in autoimmune skin disorder and their association with associated arthritis in these disorder. Materials and Methods: Serum anti-CCP antibodies and CRP was measured in 50 patients of autoimmune skin disease of which 28 were of psoriasis, 12 of Systemic Lupus Erythematosus (SLE) and 10 of Pemphigus Vulgaris (PV). These patients were categorised in two groups, with associated arthritis and without arthritis. The serum level of anti-CCP and CRP was correlated with the presence or absence of arthritis in these patients. Control group consists of 20 healthy subjects in which these two parameters were measured. Results: Out of total of 50 patients, anti-CCP was raised in 36.37% of patients with associated arthritis and 12.82% of patients without arthritis whereas CRP was raised in 63.63% of patients with arthritis and 35.89% of patients without arthritis. Mean serum anti-CCP in patient with arthritis was 15.78±13.94 U/ml and without arthritis was 7.56±7.68 U/ml with p=0.01 which was statistically significant. Mean serum CRP in arthritis was 21.11±15.51 mg/l and CRP without arthritis was 13.14±12.27 mg/l with p=0.07 which was statistically not significant. Conclusion: Although both anti-CCP and CRP are valuable markers for autoimmune skin disorder, anti-CCP seems to show significant association with arthritis. © 2017, Journal of Clinical and Diagnostic Research. All rights reserved.
Kumar N.,Patna Medical College and Hospital |
Kshitiz K.K.,Hospital and Research Institute |
Patra S.K.,Lady Hardinge Medical College
International Journal of Pharma and Bio Sciences | Year: 2010
Diabetes mellitus is a group of metabolic disorder characterized by chronic hyperglycemia and disturbances of carbohydrate, fat and protein metabolism associated with absolute or relative insulin deficiency. The present study was carried out to establish a correlationship between hyperglycemia of varying intensity with hyperlipidemia in NIDDM patients taking oral hypoglycemic drugs. The objective of the work was to find out whether hyperlipidemia was affected due to administration of a particular group of hypoglycemic drug. The total numbers of patients under study were 36 and control group consisted of 15 persons. All the 36 cases were divided according to age groups, sex, socio-economic status and dietary habits. Patients were divided into three groups i) patients taking Sulfonylurea ii) patients taking Biguanides and iii) patients taking Thiazolidinedione group of oral hypoglycemic. A morning blood sample after overnight fast was collected and serum total cholesterol, HDL and LDL cholesterol, triglycerides and plasma glucose were estimated. From the present study it is clear that Biguanides are more effective than Sulphonylureas in improving lipid profile in NIDDM cases. Also, the study suggests that NIDDM patients on oral hypoglycemic drugs are not susceptible to develop coronary artery disease.
Shandil A.,Patna Medical College and Hospital |
Kumar S.R.,Patna Medical College and Hospital
Journal of Indian Academy of Forensic Medicine | Year: 2017
The study was carried out on 500 railway related deaths in order to determine the epidemiological, forensic pathological and medico-legal profile of deceased victims brought to the mortuary of department of forensic medicine PMCH Patna between June 2011 to May 2013. Deaths due to railway accidents were 9.85% of total post-mortem examinations performed during the same period. Majority of victims (87.4 %) were male, aged between 21 - 50 years. Extensive injuries all over the body were seen in almost all the cases. Injuries to head and chest were seen in 53.6 % and chest & abdomen in 32.4 % cases. Most of the victims (86 %) died at the spot and majority of the deaths (62.8 %) were accidental, however, suicidal intension was seen in 15.2 % cases. In accidental deaths, fall from train was the commonest. Decapitation & hemi-section of the body at thoraco-abdominal area were seen in suicidal deaths.
Arundhati,Mahavir Cancer Sansthan and Research Institute |
Kumar A.,Indira Gandhi Institute of Medical science |
Kumar R.,Patna Medical College and Hospital
Indian Journal of Hematology and Blood Transfusion | Year: 2011
Microfilariae in bone marrow aspirates have been reported occasionally, but until now no case has been reported in association with acute leukaemia. This is a unique finding, not mentioned in literature. Microfilariae are seen mainly in peripheral blood smears (PBS) and rarely in bone marrow aspirate, but this surprisingly did not show any parasite in PBS. Meticulous examination of bone marrow smears revealed acute lymphoblastic leukaemia and a few interspersed microfilariae. This rare combination, reported for the first time, definitely needs a space in literature. © Indian Society of Haematology & Transfusion Medicine 2011.
Bhartiya R.,Patna Medical College and Hospital |
Prasad K.M.,Patna Medical College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2015
Malignant Melanoma of nasal cavity is an extremely rare tumour and is more aggressive than its cutaneous counterpart. Primary malignant melanoma of nasal cavity arise from melanocytes located in the mucous membrane. Only 0.5% of malignant melanoma arises in nasal cavity. We report a case of malignant melanoma of the nasal cavity in a 51-year-old male who presented with swelling of nose, nasal block and epistaxis. By brush cytology and CT scan imaging, the pre operative diagnosis of malignant melanoma was made which was later confirmed by histopathology examination along with immunohistochemistry by using S100 and HMB 45. Malignant melanoma of nose is rare tumour, with aggressive behavior and poor prognosis. Rarity of this lesion warrants its mention and emphasizes the importance of considering malignant melanoma among the differential diagnosis of tumours of nose and paranasal sinuses. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.
Kumar S.,All India Institute of Medical Sciences |
Singh R.K.P.,Patna Medical College and Hospital
Journal of Indian Academy of Forensic Medicine | Year: 2014
Among all type of accidents, those caused by motor vehicle claims the largest toll of life and tend to be the most serious. The present prospective study was conducted in the Department of Forensic Medicine and Toxicology, Patna Medical College and Hospital Patna from September, 2007 to April, 2009 on 100 cases. The primary aim of this study was to find out nature and types of cranio-cerebral injuries (CCI) sustained in fatal road traffic accidents (RTA) and make an attempt to establish various causative factors, patterns and distribution of CCI and thereby to plan successful measures against it. Our study shows that 30% victims were of middle age group, male: female ratio was 4.5:1. Maximum number of cases was during the summer season. 66% victims were pedestrians; in 47% cases heavy vehicles were involved. In 86% cases the death was due to fatal cranio-cerebral injuries alone. In 30% cases the death was instantaneous, 65% cases died within 48 hours after the injury and were able to obtain only minor surgical aid and only 9% cases died after 48 hours of the injury receiving definitive surgical treatment.
Priyadarshi R.N.,Indira Gandhi Institute of Medical science |
Anand U.,Indira Gandhi Institute of Medical science |
Kumar B.,Indira Gandhi Institute of Medical science |
Prakash V.,Patna Medical College and Hospital
Abdominal Imaging | Year: 2013
Wandering spleen is a rare occurrence. Torsion of the splenic pedicle is the major life-threatening complication of this entity. Preoperative diagnosis is based on radiological investigation. We report two consecutive cases, one adult and one child, in whom torsion in a wandering spleen was diagnosed based on a typical whirled appearance of the splenic vessels on computed tomography. We present a review of computed tomographic appearance of splenic torsion, and emphasize the "whirled appearance" as a specific sign for splenic torsion in wandering spleen. © 2012 Springer Science+Business Media, LLC.
Rani J.,Government Medical College and Hospital |
Sharma D.,Patna Medical College and Hospital |
Sehgal A.,Government Medical College and Hospital
Archives of Gynecology and Obstetrics | Year: 2014
Background Cervical dilatation documented on partogram indicates expected rate of progress of labour and deviations from alert line indicates abnormal progress of labour. Its early detection and timely intervention can reduce fetomaternal morbidity. Purpose To study the role of partogram in the management of labouring mothers with high risk pregnancies at a tertiary care centre. Method Four hundred primigravidas with high risk pregnancies in active labour (with cervical dilatation ≥ 4 cm) were studied, divided into two groups as Partogram and no Partogram group and each group consisted of 200 patients. In Partogram group, progress of labour was documented on modified WHO partograph along with the notes on progress sheet of case record file while by standard notes only in no Partogram group. Cases included were pregnancy-induced hypertension, gestational diabetes mellitus, cholestasis, hypothyroidism, history of previous one LSCS for trial of labour, postdated pregnancy. Management of labour was standardised using set protocols of intrapartum care followed by analysis of duration of labour, rate of intervention, maternal and perinatal outcomes in both group. Result Though percentage of normal vaginal delivery was higher in Partogram group (71.5 %) than no Partogram group (68 %), no statistically significant difference was found between two groups regarding mean duration of active phase of first and second stage of labour, rate of operative vaginal deliveries (partogram 12 % and no partogram 12.5 %) and of caesarean section (Partogram 16.5 %, no Partogram 18.5 %) and perinatal outcome. Conclusion In this study, partogram had no significant impact on duration of labour, rate of operative interventions and perinatal outcome following its use in the labour management of high risk pregnancies. © 2014 Springer-Verlag Berlin Heidelberg.
Kumar R.,Patna Medical College and Hospital
Journal of the Indian Medical Association | Year: 2016
Cases of post-Hansen’s deformities are still prevalent in our country. They do report for reconstructive surgeries at tertiary level hospitals for surgery. Most patients were in the age group 11-30 years. Males were in higher proportions. In cases of hand deformities, Lasso procedure was the commonest operation. Among postoperative complications, fusion of proximal interphalangeal (PIP) joints and stiffness followed by infection were the commonest complications. © 2016, Indian Medical Association. All rights reserved.