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Blacktown, Australia

Weston K.M.,University of Wollongong | Gallagher W.C.,State Records Authority of New South Wales | Branley J.M.,Pathology West | Branley J.M.,University of Sydney
Medical Journal of Australia | Year: 2014

A parcel is delivered to the local Public Health Unit from the New South Wales State Records Authority. It contains copies of letters written in May 1841, between the then New South Wales Governor, Sir George Gipps, and Dr J V Thompson, Deputy Inspector General of Hospitals. Enclosed is a small package containing two glass slides, sealed together, guarding vaccine material crucial in protecting the young colony from the scourge of smallpox. In the same week, the world mourns the death of Sir Frank Fenner, celebrated champion in the global eradication of smallpox, who had stood before the World Health Assembly some 30 years earlier and declared that the dreadful disease was extinct. Source

Favaloro E.J.,West Health Institute | McVicker W.,West Health Institute | Lay M.,West Health Institute | Ahuja M.,West Health Institute | And 3 more authors.
American Journal of Clinical Pathology | Year: 2016

Objectives: To reduce interlaboratory variation and bias in international normalized ratio (INR) results, as used to monitor patients receiving vitamin K antagonist therapy, including warfarin, in a large pathology network (n=27 laboratories) by procedural standardization and harmonization. Methods: Network consensus to standardize to common instrument and reagent platforms was established, following development of hemostasis test specifications. Subsequent installations and implementation occurred after conclusion of a government tender process. Network-wide application of simple novel process of verification harmonization of local international sensitive index and mean normal prothrombin time initiated for each new lot of INR reagent that does not require ongoing use of reference thromboplastin or calibration/certified plasma sets. Results: We achieved reduction of different instrument manufacturers (from four to one), instrument types (10 to three), reagent types (four to one), and instrument/reagent combinations (12 to three), plus substantial reduction in INR variability and bias. Conclusions: Results infer significant improvement in local patient management, with positive implications for other laboratories. For the United States in particular, lack of US Food and Drug Administration-cleared certified plasmas may compromise INR accuracy, and our novel approach may provide a workable alternative for laboratories and networks. © 2016 American Society for Clinical Pathology. All rights reserved. Source

Chou S.,Pathology West | Subramanian V.,Pathology West | Lau H.M.H.,Westmead Hospital | Achan A.,Pathology West
International Journal of Surgical Pathology | Year: 2014

Benign vascular lesions have a diverse appearance and can be extremely difficult to classify. We present renal anastomosing hemangiomas from 2 patients that exemplify the potential diverse range of appearances that can occur in this recently described, rare variant of capillary hemangioma. The lesion from one patient was an intravenous hemangioma with closely packed, fenestrated vascular channels that were reminiscent of the splenic red pulp. Also, the endothelial cells contained hyaline globules. On the other hand, the second patient had multifocal tumor. The lesions showed more extensive hyalinization and vascular ectasia reminiscent of cavernous hemangioma. Extramedullary hematopoiesis was a feature in all the tumors, particularly in the second patient where numerous immature blasts were present within vascular spaces. © The Author(s) 2013. Source

Dang K.,Pathology West | Dang K.,Nankai University | Toi C.S.,Pathology West | Lilly D.G.,Pathology West | And 2 more authors.
Pest Management Science | Year: 2015

BACKGROUND: Pyrethroid resistance in the common bed bug, Cimex lectularius L., has been reported worldwide. An important resistance mechanism is via knockdown resistance (kdr) mutations, notably V419L and L925I. Information regarding this kdr-type resistance mechanism is unknown in Australia. This study aims to examine the status of kdr mutations in Australian C. lectularius strains. RESULTS: Several modern field-collected strains and museum-preserved reference collections of Australian C. lectularius were examined. Of the field strains (2007-2013), 96% had the known kdr mutations (L925I or both V419L/L925I). The 'Adelaide' strain (2013) and samples from the preserved reference collections (1994-2002) revealed no known kdr mutations. A novel mutation I936F was apparent in the insecticide-resistant 'Adelaide' strain, one strain from Perth (with L925I) and the majority of the reference collection specimens. The laboratory insecticide-resistant 'Sydney' strain showed a mixture of no kdr mutations (20%) and L925I (80%). CONCLUSION: The novel mutation I936F may be a kdr mutation but appeared to contribute less resistance to the pyrethroids than the V419L and L925I mutations. The detection of high frequencies of kdr mutations indicates that kdr-type resistance is widespread across Australia. Hence, there should be a reduced reliance on pyrethroid insecticides and an integrated management approach for the control of C. lectularius infestations. © 2015 Society of Chemical Industry. Source

Lin M.-W.,Pathology West | Lin M.-W.,University of Sydney | Silvestrini R.A.,Pathology West | Culican S.,Pathology West | And 3 more authors.
American Journal of Clinical Pathology | Year: 2014

Objectives: To determine whether the addition of a formalin-fixed neutrophil substrate could improve interpretation and prediction of autoantigenic specificity in antineutrophil cytoplasmic antibody (ANCA) testing.Methods: Routine diagnostic samples sent for ANCA testing were analyzed prospectively on a dual substrate of both ethanol- and formalin-fixed neutrophils. Positive samples on ethanol-fixed neutrophils were deemed "typical" if formalin-fixed neutrophils also stained, and "atypical" if not. Indirect immunofluorescence (IIF) results were correlated with antimyeloperoxidase (MPO) and anti-proteinase 3 (PR3) results with an enzyme-linked immunosorbent assay (ELISA).Results: Of 1,426 samples, 201 from unique patients were ANCA-positive (200 on IIF, 1 on ELISA alone). Thirty-two (45%) of 71 typical ANCA staining patterns were positive for either an anti-MPO or anti-PR3 antibodies, whereas only one (0.8%) of 129 atypical patterns was ELISA-positive, in a patient without systemic vasculitis. Only one (3%) of 34 ELISA-positive samples had a negative IIF-ANCA (1/1,426 patients, 0.07%), and this patient did not have vasculitis.Conclusions: Concomitant staining on formalin fixation of IIF-positive ethanol-fixed ANCA samples improves the interpretation of ANCA testing and is predictive of vasculitis autoantigens MPO and PR3. © American Society for Clinical Pathology. Source

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