Toluca de Lerdo, Mexico
Toluca de Lerdo, Mexico

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LAS VEGAS--(BUSINESS WIRE)--LMC Pathology Services, an Aurora Diagnostics specialty practice in Las Vegas, Nevada, was selected by Ventana Medical Systems, a Roche Diagnostics Company, as one of the first pathology groups in the United States to begin providing VENTANA’s PD-L1 (SP142) Assay. This complementary assay is an immunohistochemical tissue stain corresponding with the release of Genentech’s TECENTRIQ™ (atezolizumab). The Food and Drug Administration (FDA) approved TECENTRIQ™ October 18


Rathi V.M.,LV Prasad Eye Institute | Vemuganti G.K.,Pathology Services | Sangwan V.S.,LV Prasad Eye Institute | Kannabiran C.,LV Prasad Eye Institute
Indian Journal of Ophthalmology | Year: 2011

We report a rare case of keratoconus with granular dystrophy with a follow-up of two decades, documenting the sequential presentation of two diseases confirmed by histology and genetic studies. A 13-year-old boy was diagnosed in 1988 with keratoconus in both eyes (BE) based on slit-lamp biomicroscopy findings of corneal ectasia in BE accompanied by Fleischer's ring, Vogt's striae, a small, old, healed hydrops. The left eye (LE) had central corneal thinning and scar in the central area involving the mid and posterior stroma secondary to healed hydrops. Penetrating keratoplasty (PKP) was advised. The boy was lost to follow-up till 1991 and presented with white, dot-like opacities in the central cornea in the RE only, suggestive of granular corneal dystrophy. Similar findings of white, dot-like opacities were noted in the LE in 1995 and the patient subsequently underwent PKP in BE. Histopathology of corneal buttons confirmed the presence of patchy, crystal-like orange deposits, which stained bright red with Masson's trichrome. Mutational analysis of the TGFBI gene in patient's DNA revealed a heterozygous mutation corresponding to a change in Arg555Trp in the keratoepithelin protein. Granular dystrophy recurred after 8 years in the RE.


Becerril J.L.M.,National Autonomous University of Mexico | Benitez J.G.S.,Mexico State University | Benitez J.G.S.,National Autonomous University of Mexico | Juarez J.J.T.,Maternal Perinatal Hospital Monica Pretelini Saenz HMPMPS | And 3 more authors.
Biochemical Genetics | Year: 2015

Breast cancer is the most frequent neoplasia in women and is responsible for approximately 13.8% of deaths per year for this gender. It has been suggested that JAK2, STAT3, and NF-κB gene expression is involved in this type of cancer. The objective of the present study was to determine the effect of bistriazole in these signaling pathways in patients with breast cancer and benign mammary lesions. The inhibitory concentration 50 of bistriazole was calculated in cell cultures of patients with benign lesions, Probit = 4.6 μM with IC = 95%. The study was performed by examining 63 women who submitted to mammary biopsies. Biopsies of the mammary lesions were performed, gene expression was determined, and cells were cultured in the presence of 4.6 μM bistriazole. We found that breast cancer is related to age greater than 50 (P ≤ 0.01), being overweight (P ≤ 0.023) and having a waist circumference larger than 80 cm (P ≤ 0.01). The gene expression of JAK2, STAT3, and NF-κB was higher in groups of patients with breast cancer, while SOCS3 expression was lower. After being exposed to bistriazole, the expression of JAK2 and STAT3 decreased, and the expression of SOCS3 and NF-κB increased. In conclusion, this molecule in development has an effect on the gene expression of JAK3 and STAT3; nevertheless, the lack of change in NF-κB indicates that it is not a regulator of inflammation, and therefore, more studies should be performed. © 2015, Springer Science+Business Media New York.


PubMed | National Autonomous University of Mexico, Maternal Perinatal Hospital Monica Pretelini Saenz HMPMPS, Mexico State University and Pathology Services
Type: Journal Article | Journal: Biochemical genetics | Year: 2015

Breast cancer is the most frequent neoplasia in women and is responsible for approximately 13.8% of deaths per year for this gender. It has been suggested that JAK2, STAT3, and NF-B gene expression is involved in this type of cancer. The objective of the present study was to determine the effect of bistriazole in these signaling pathways in patients with breast cancer and benign mammary lesions. The inhibitory concentration 50 of bistriazole was calculated in cell cultures of patients with benign lesions, Probit=4.6M with IC=95%. The study was performed by examining 63 women who submitted to mammary biopsies. Biopsies of the mammary lesions were performed, gene expression was determined, and cells were cultured in the presence of 4.6M bistriazole. We found that breast cancer is related to age greater than 50 (P0.01), being overweight (P0.023) and having a waist circumference larger than 80cm (P0.01). The gene expression of JAK2, STAT3, and NF-B was higher in groups of patients with breast cancer, while SOCS3 expression was lower. After being exposed to bistriazole, the expression of JAK2 and STAT3 decreased, and the expression of SOCS3 and NF-B increased. In conclusion, this molecule in development has an effect on the gene expression of JAK3 and STAT3; nevertheless, the lack of change in NF-B indicates that it is not a regulator of inflammation, and therefore, more studies should be performed.

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