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Yasouj, Iran

Ghaedi M.,Yasouj University | Naghiha R.,Yasouj University | Jannesar R.,Pathology Group | dehghanian N.,Payame Noor University | And 2 more authors.
Journal of Industrial and Engineering Chemistry | Year: 2015

The aim of this study was assess the new safe drugs with high efficacy that prepared with available plant and nano particles. In the present study, the microbial activity of Zn[OH]2 nanoparticles and Hp-2-minh as sole or combination of extracts of Utica dioica Chamaemelum nobile and Salvia officinalis. The antimicrobial activity determined using agar disc diffusion method. The antibacterial and antifungal activities of U. dioica, C. Nobile and S. officinalis extracts [25,50, 100μg/mL] were tested against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeroginosa, and fungal strains were Aspergillus oryzae, Candida albicans. It was revealed that extracts antibacterial potential significantly depend on their dosage and their influence related to the presence of various secondary metabolites. © 2015 The Korean Society of Industrial and Engineering Chemistry. Source

Dashamiri S.,Yasouj University | Ghaedi M.,Yasouj University | Dashtian K.,Yasouj University | Rahimi M.R.,Yasouj University | And 2 more authors.
Ultrasonics Sonochemistry | Year: 2016

Copper oxide nanoparticles loaded on activated carbon (CuO-NPs-AC) were prepared and fully analyzed and characterized with FE-SEM, XRD and FT-IR. Subsequently, this novel material was used for simultaneous ultrasound-assisted adsorption of brilliant green (BG), auramine O (AO), methylene blue (MB) and eosin yellow (EY) dyes. Problems regard to dyes spectra overlap in quaternary solution of this dyes were omitted by derivative spectrophotometric method. The best pH in quaternary system was studied by using one at a time method to achieved maximum dyes removal percentage. Subsequently, sonication time, adsorbent dosage and initial dyes concentrations influence on dyes removal was optimized by central composite design (CCD) combined with desirability function approach (DFA). Desirability score of 0.978 show optimum conditions set at sonication time (4.2 min), adsorbent mass (0.029 g), initial dyes concentration (4.5 mg L-1). Under this optimum condition the removal percentage for MB, AO, EY and BG dyes 97.58, 94.66, 96.22 and 94.93, respectively. The adsorption rate well fitted by pseudo second-order while adsorption capacity according to the Langmuir model as best equilibrium isotherm model for BG, MB, AO and EY was 20.48, 21.26, 22.34 and 21.29 mg g-1, respectively. © 2016 Published by Elsevier B.V. Source

Jones H.B.,Pathology Group | Jones H.B.,Astrazeneca | Bigley A.L.,Pathology Group | Pemberton J.,Astrazeneca | Randall K.J.,Pathology Group
Toxicologic Pathology | Year: 2013

Islets of Langerhans represent a heterogeneous population in insulin resistant and diabetic animals and humans as histological appearances and function vary substantially. Mathematical representation that reflects this morphological diversity will assist in assessment of degeneration and regeneration, enabling comparisons between species, strains, and experimental investigations. Our investigative approach used a model of islet degeneration in diabetic male obese Zucker Diabetic Fatty (ZDF) rats and evaluated its prevention using rosiglitazone treatment. Immunohistochemical staining (insulin and collagens I/III) with automated image analysis reliably measured numbers, area, clustering, and staining intensity of β-cells and degree of islet fibrosis. Finite mixture mathematical modeling for the joint probability distribution of seven islet parameters to represent islet numerical data variation provided an automatic procedure for islet category allocations as normal or abnormal. Allocations for obese ZDF controls and rosiglitazone-treated animals were significantly different, with no significant difference between the latter and lean ZDF controls, indicative of differences within islet populations of individual animals, between lean and obese rat strains and following drug treatment. Islet morphology showed clear association with mathematical characterization. Information on islet morphology obtained by histopathological assessment of single pancreatic tissue sections was confirmed by this method showing drug-induced retardation of islet of Langerhans degeneration. © 2013 by The Author(s). Source

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