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Woburn, MA, United States

Meltzer R.H.,Pathogenetix
Botulinum Journal | Year: 2012

Detection and identification of Clostridium botulinum is of particular concern due to the extreme pathogenicity of its toxin. Herein, we review the potential applicability of two novel technologies for detection of Clostridium botulinum and botulinum toxin. Genome sequence scanning (GSS) provides strain-specific bacterial identification from complex bacterial mixtures by detecting the distribution of fluorescent sequence-specific probes along long linearised DNA fragments. Digital DNA (DD) utilises long fluorescent labelled DNA molecules as binary labelled tags to facilitate multiplex antigen detection. Both technologies share automated sample preparation and detection instrumentation. GSS and DD have particular applicability for botulinum detection and identification, but have broad-reaching applicability to food safety testing and clinical diagnostics in general. © 2012 Inderscience Enterprises Ltd.

Pathogenetix | Date: 2013-01-23

Aspects of the invention relate to devices and methods of use thereof for concentrating, positioning and/or manipulating agents within a fluid, including but not limited to genomic DNA.

A method of controlling the concentration of a sample flowing through a microchannel is provided. The method includes flowing a sample carrier fluid from a sample carrier channel and into an upstream portion of a microchannel such that the sample carrier fluid flows from the upstream portion and toward a downstream portion of the microchannel, and flowing a sheathing fluid from a sheathing fluid channel and into the upstream portion of the microchannel such that the sheathing fluid flows from the upstream portion and toward the downstream portion of the microchannel, and generally parallel to the sample carrier fluid. The method further includes detecting a concentration of a sample in the sample carrier fluid in the downstream portion of the microchannel, and adjusting a flow rate of at least one of the sample carrier fluid and the sheathing fluid based upon the detected concentration of the sample.

Pathogenetix | Date: 2013-04-12

The invention provides structures and methods that allow polymers of any length, including nucleic acids, to be stretched into a long, linear conformation for further analysis.

Pathogenetix | Date: 2014-01-23

The invention provides a device for preparing a fluid sample, including but not limited to a sample comprising genomic DNA.

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