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Buser J.R.,University of Washington | Diesburg S.,PATH The Program for Appropriate Technology in Healthcare | Singleton J.,PATH The Program for Appropriate Technology in Healthcare | Guelig D.,PATH The Program for Appropriate Technology in Healthcare | And 6 more authors.
Lab on a Chip - Miniaturisation for Chemistry and Biology | Year: 2015

Decoupling nucleic acid amplification assays from infrastructure requirements such as grid electricity is critical for providing effective diagnosis and treatment at the point of care in low-resource settings. Here, we outline a complete strategy for the design of electricity-free precision heaters compatible with medical diagnostic applications requiring isothermal conditions, including nucleic acid amplification and lysis. Low-cost, highly energy dense components with better end-of-life disposal options than conventional batteries are proposed as an alternative to conventional heating methods to satisfy the unique needs of point of care use. © The Royal Society of Chemistry. Source

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