Shirwaikar A.,Gulf Medical University |
Devi S.,Pariyaram Medical College |
Rajagopal P.L.,Academy of Pharmaceutical Science |
Kiron S.S.,Academy of Pharmaceutical Science |
Sreejith K.R.,Academy of Pharmaceutical Science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014
Objective: To develop and validate a simple, precise and sensitive extractive spectrophotometric method for the assay of Donepezil HCl in pure and pharmaceutical preparations. Method: It is based on the formation of ion-pair complex between the drug and Bromo cresol purple in phthalate buffer solution. The formed complex was extracted with chloroform and measured at 410 nm. Results: Beer's law was obeyed in the range 2-14 μg/ ml with correlation coefficient (n = 6) ≥ 0.9999.The molar absorptivity, Sandell sensitivity, detection and quantification limits were also calculated. The composition of the ion pairs was found 1:1 by Job's method. Conclusion: This developed method was validated for accuracy and precision and has been applied successfully for the analysis of Donepezil in pure and in its dosage forms.
Arunshirwaikar A.,Gulf Medical University |
Premkumar N.,Pariyaram Medical College |
Sarala A.,Pariyaram Medical College |
Bhaskaran K.,Pariyaram Medical College |
Rajagopal P.L.,Academy of Pharmaceutical science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012
Objective: The primary objective of this study was to determine drug utilization and evaluation of adjuvant therapy in mild to severe asthma patient and whether adjuvant therapy like montelukast, an oral leukotriene receptor antagonist and theophyline, provides additional clinical benefit with prescribed asthma therapy. Study design: The present study was an open labeled study conducted for a period of two years with mild to severe asthma patients in a tertiary care hospital and Private clinics in North Malabar region of Kerala. A total of 64 patients with mild to severe asthma were included in this study. Results: In these 64 patients, 12.5% received adjuvant therapy; in these 9.5% received montelukast.LTa added baseline PFT (1.59± 0.66) and 90th day follow-up PFT (2.66±0.67) showed improvement (1.07unit) and QoL improvement (27.46unit). LTa included asthma therapy had showed -0.62 units clinical improvement in pulmonary function test and -7.49 units quality of life, when compared to other adjuvant therapy like theophyline. Conclusion: all treatments were well tolerated, adjuvant therapy in bronchial asthma patients was found to be minimal in this area, including montelukast add on asthma therapy, patients showed additional improvement in quality of life comparing with theophyline.
Yaranal P.J.,Kannur Medical College |
Harish S.G.,Basaveshwar Medical College |
Purushotham B.,Pariyaram Medical College
Indian Journal of Cancer | Year: 2014
Introduction: Primary intestinal lymphoma (PIL) is defined as an extranodal lymphoma arising in the intestine. This study includes 11 PILs. Objectives: The objective of this study was to evaluate the clinicopathological characteristics of primary non-Hodgkin′s lymphoma (NHL) in the small and large intestine. All cases were reclassified according to the World Health Organization classification of lymphoma in 2001. Immunohistochemistry (IHC) was used to confirm the histopathological diagnosis. Materials and Methods: Eleven cases of primary non-Hodgkin in the small and large intestine were studied retrospectively in a 5 year period. There were seven cases of resected intestinal specimens and four biopsy specimens. Five cases from ileum and two cases each from caecum and duodenum and one case each from jejunum and duodenum. Hematoxylin and eosin stained sections were studied with light microscopy and IHC for CD5, 20, 21 and cyclin D1 were done. Results: It is a retrospective study of 11 cases of intestinal lymphomas. Abdominal pain and abdominal lump were two main common presenting symptoms. NHLs were more common in the small intestine. PILs are common in adults (75% above 46 years) with male preponderance. All were NHLs and B-cell type. Five cases were diffuse large B-cell lymphoma and four cases each were mucosa-associated lymphatic tissue lymphoma and follicular lymphoma. One case was lymphomatoid polyposis or mantle cell lymphoma. Conclusion: PILs is rare and differs significantly from their gastric counterpart, not only in pathology but also with regard to clinical features, management and prognosis. Due to the lack of characteristic symptoms and a low incidence rate, PIL is misdiagnosed until serious complications occur, such as perforation and bleeding and hence needs to be accurately diagnosed.
Kulkarni C.,KMC |
George T.A.,Pariyaram Medical College |
Asha A.V.,Pariyaram Medical College |
Ravindran R.,Pariyaram Medical College
Journal of Clinical and Diagnostic Research | Year: 2014
Acute angle closure glaucoma is rarely seen as complication of snake bite.We report three cases of bilateral acute angle closure glaucoma with capillary leak syndrome and acute renal failure secondary to hematotoxic snake bites. We are also briefly discussing the association of capillary leak syndrome and angle closure glaucoma in hematotoxic snake bite. This is the first time an association between angle closure and capillary leak syndrome following snake bite is reported.Study type: Descriptive case series.Materials and Methods: Records of all patients admitted to ICU with snake bite were reviewed to identify cases developing acute angle closure glaucoma. These cases with acute angle closure glaucoma are analysed in detail for systemic condition. Diagnosis, management and outcome of cases are described.Results: Of the 119 snake bites admitted, 47 patients had confirmed hematotoxic snake bite. 15 of these patients underwent hemodialysis for acute renal failure. 7 of them were diagnosed to have capillary leak syndrome and all of them complained of decreased vision. 3 of the 7 cases had acute angle closure glaucoma on the second day of bite. One of the patients expired and other two recovered fully, both of them had normal IOP and good vision at one month follow up.Conclusion: Acute angle closure glaucoma seems to be associated with systemic capillary leak syndrome in hematotoxic snake bite. High suspicion, early recognition, timely and appropriate treatment can prevent visual loss in this rare complication. © 2014, Journal of Clinical and Diagnostic Research. All rights reserved.
Indiran V.,Sree Balaji Medical College and Hospital |
Valiyakath S.,Pariyaram medical College |
Maduraimuthu P.,Sree Balaji Medical College and Hospital
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015
A large spectrum of pathologic entities including benign and malignant lesions is found in the thyroid gland. Lesions of thyroid gland represent some of the most heterogeneous abnormalities in the head and neck. The purpose of this study was to detect thyroid lesions and to differentiate between benign and malignant pathology, based on their sonographic appearance. We evaluated 90 patients with thyroid swelling using high resolution sonography and color Doppler and followed up with HPE. The present study had a sensitivity of 66.6%, specificity of 96.7% and diagnostic accuracy of 91%. The sensitivity and specificity of ultrasonography in various other studies range from 60-75% and 59-91% respectively. Such wide variation in predictive values is usually attributed to the fact of ultrasonography being highly operator dependent. High resolution sonography performed by a skilled radiologist is very sensitive and is recommended as the primary imaging modality in evaluation of thyroid diseases. It has a high sensitivity and specificity in the diagnosis of thyroid diseases. Sonography examination can be regarded as an excellent investigation for differentiating solid, cystic and mixed lesions; for locating clinically non palpable nodules and for follow up of benign thyroid nodules.
Vivekanand U.,Kasturba Medical College |
Shetty A.,Kasturba Medical College |
Kulkarni C.,Pariyaram Medical College
Tropical Doctor | Year: 2011
We report the final outcomes, based on final visual acuity, of patients who underwent cataract surgery at an outreach rural ophthalmology unit and document the details of the ophthalmic examination, type of surgery, intra- and postoperative complications and the final visual acuity. Of 208 eyes (198 patients), 81.3% had small incision cataract surgery and 18.7% had phacoemulsification. We believe that, with good planning and the proper utilization of available resources, it is possible to achieve a good visual outcome in the great majority of cases.
Chacko E.C.,Singapore General Hospital |
Surrun S.K.,Singapore General Hospital |
Mubarack Sani T.P.,Pariyaram Medical College |
Pappachan J.M.,Singapore General Hospital
Postgraduate Medical Journal | Year: 2010
Chronic kidney disease (CKD) has become a major public health problem worldwide over the past few decades because of the increasing prevalence of hypertension, diabetes mellitus, and elderly individuals in most countries. Chronic viral hepatitis (due to hepatitis B virus (HBV) and hepatitis C virus (HCV)) also poses significant morbidity and mortality globally. Both these viruses can cause CKD and these infections can occur as a consequence of CKD management. CKD patients acquiring HBV or HCV infection have higher morbidity and mortality rates, and the management of these infections among CKD patients with antiviral agents is associated with high rates of adverse effects. The optimal management of CKD associated with HBV and HCV is not well defined because of insufficient data from clinical trials. This review discusses the pathogenesis, clinical characteristics and management issues related to chronic viral hepatitis and CKD.
Bindurani S.,Pariyaram Medical College |
Rajiv S.,Pariyaram Medical College
International Journal of Trichology | Year: 2013
Monilethrix is a rare autosomal dominant hair shaft disorder with variable expressivity. It usually presents with short broken scalp hairs and follicular hyperkeratosis. Light microscopy of hair reveals a beaded appearance. Here, we report the case of a 32-year-old male who presented with sparse hair and follicular keratotic papules in the absence of any family history.
Thyvalappil A.,P.A. College |
Sudhamani B.,P.A. College |
Kizhakkethara G.,Pariyaram Medical College |
Sridharan R.,P.A. College |
Kunjan R.,P.A. College
Indian Journal of Dermatology | Year: 2015
Paraganglioma-like dermal melanocytic tumor (PDMT) is a rare subtype of benign dermal melanocytic tumor, first described in 2004. Its histopathologic features resemble those of paraganglioma, showing presence of a distinctive partitioning of the tumor into small and large packets, nests, or short cords by delicate fibrous septa (zellballen pattern). But the immunostaining characteristics are those of melanocytic lesions, as PDMT express S-100, melan A, HMB 45 and lack pancytokeratin markers. It has a benign course, although a lesion of low malignant potential cannot be excluded. We describe a case of 60-year-old female who presented with three PDMT lesions on her right leg. To the best of our knowledge this is the first case reported from India. © 2015 Indian Journal of Dermatology.
PubMed | Pariyaram Medical College
Type: Journal Article | Journal: Indian journal of dermatology | Year: 2015
Paraganglioma-like dermal melanocytic tumor (PDMT) is a rare subtype of benign dermal melanocytic tumor, first described in 2004. Its histopathologic features resemble those of paraganglioma, showing presence of a distinctive partitioning of the tumor into small and large packets, nests, or short cords by delicate fibrous septa (zellballen pattern). But the immunostaining characteristics are those of melanocytic lesions, as PDMT express S-100, melan A, HMB 45 and lack pancytokeratin markers. It has a benign course, although a lesion of low malignant potential cannot be excluded. We describe a case of 60-year-old female who presented with three PDMT lesions on her right leg. To the best of our knowledge this is the first case reported from India.