Pariyaram Medical College
Pariyaram Medical College
Chandnani S.R.,Bombay Maternity and Surgical Hospital |
Ramakrishna C.D.,Pariyaram Medical College |
Dave B.A.,Manish Therapy ServicesTX |
Kothavade P.S.,Meril Life science Pvt. Ltd |
Thakkar A.S.,Meril Life science Pvt. Ltd.
Journal of Clinical and Diagnostic Research | Year: 2017
Introduction: The performance of Blood Glucose Monitoring System (BGMS) is critical as the information provided by the system guide the patient or health care professional in making treatment decisions. However, besides evaluating accuracy of the BGMS in laboratory setting, it is equally important that the intended users (healthcare professionals and patients) should be able to achieve blood glucose measurements with similar level of high accuracy. Aim: To assess the performance of EXIMO™ (Meril Diagnostics Pvt. Ltd., Vapi, Gujarat, India) BGMS as per International Organization for Standardization (ISO) 15197:2013 section 8 user performance criteria. Materials and Methods: This was a non-randomized and post-marketing study conducted at a tertiary care centre of India. A total of 1005 patients with diabetes themselves performed fingertip blood glucose measurement using EXIMO™ BGMS. Immediately after capillary blood glucose measurement using the blood glucose monitoring system, venous blood sample from each patient was obtained by a trained technician which was assessed by reference laboratory method- Cobas Integra 400 plus (Roche Instrument Centre, Rotkreuz, Switzerland). All the blood glucose measurements assessed by EXIMO™ were compared with laboratory results. Performance of the system was assessed as per ISO 15197:2013 criteria using Bland-Altman plot, Parkes-Consensus Error Grid (CEG) and Surveillance Error Grid analyses (SEG). Results: A total of 1005 patients participated in the study. Average age of the patients was 44.93±14.65 years. Evaluation of capillary fingertip blood glucose measurements demonstrated that 95.82% measurements fulfilled ISO 15197:2013 section 8 user performance criteria. All the results lie within clinically non-critical zones; Zone A (99.47%; n=1000) and Zone B (0.53%; n=05) of the CEG analysis. As per SEG analysis, majority of the results fell within “no-risk” zone (risk score 0 to 0.5; 90.42%). Conclusion: The result of the study confirmed that intended users are able to obtain accurate glucose measurements when operating EXIMO™ BGMS, given only the instructions and training materials routinely provided with the system, in clinical practice. © 2017, Journal of Clinical and Diagnostic Research. All rights reserved.
Keshavamurthy H.R.,Pariyaram Medical College |
Stephen S.,Pariyaram Medical College
Biomedicine (India) | Year: 2017
Introduction and Aim: It is well known that obesity is related to hypertension through several mechanisms, such as sympathetic overactivity and excess renal sodium reabsorption. Obesity and hypertension may also be linked by leptin, a peptide that is elevated in obese individuals. Leptin is an adipocyte derived hormone that acts in the hypothalamus to regulate appetite, energy expenditure and sympathetic nervous system outflow, as well as in peripheral tissues, such as blood vessels and kidneys. The objectives of the study were to estimate and compare Serum Leptin levels, Blood Urea, Serum Creatinine and FBS in Hypertensive Obese and Normotensive obese subjects. Materials and Methods: The study was carried out in 45 Hypertensive obese cases, in the age group of 30-60 years and 45 age and gender matched Normotensive obese controls. Fasting blood samples were collected. Serum Leptin was estimated by ELISA method. Blood Urea was determined by Specific Urease/Glutamate dehydrogenase method. Serum Creatinine was estimated by Jaffe's Alkaline Picrate method. Blood sugar was estimated by GOD/POD method. Results: Patients with obese Hypertension were 36% male and 64% female. The obese Hypertensive group showed significantly higher values of Leptin (p<0.05), FBS (p<0.05), Urea (p<0.05), Creatinine (p<0.05). Leptin showed a positive significant correlation with BMI, blood Urea and serum Creatinine in the obese Hypertensive group. And negative correlation with FBS was seen. Conclusion: The parameters such as Leptin, FBS, Urea and Creatinine were significantly elevated in the study Group. All the above derangements confirm that Leptin correlates with Hypertension and the mechanisms for the development of selective Leptin resistance seem to be the main leading cause for the development of obesity related hypertension.
Shirwaikar A.,Gulf Medical University |
Devi S.,Pariyaram Medical College |
Siju E.N.,Academy of Pharmaceutical Science
International Journal of PharmTech Research | Year: 2011
In the present study, the ethyl alcohol and aqueous extract of Thespesia populnea were investigated for anti-inflammatory activity by HRBC method. The preventation of hypo tonicity induced HRBC membrane lysis was taken a measure of anti-inflammatory activity.These extracts show biphasic effects. Their activities were compared with standard drug diclofenac.
Shirwaikar A.,Gulf Medical University |
Devi S.,Pariyaram Medical College |
Rajagopal P.L.,Academy of Pharmaceutical Science |
Kiron S.S.,Academy of Pharmaceutical Science |
Sreejith K.R.,Academy of Pharmaceutical Science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014
Objective: To develop and validate a simple, precise and sensitive extractive spectrophotometric method for the assay of Donepezil HCl in pure and pharmaceutical preparations. Method: It is based on the formation of ion-pair complex between the drug and Bromo cresol purple in phthalate buffer solution. The formed complex was extracted with chloroform and measured at 410 nm. Results: Beer's law was obeyed in the range 2-14 μg/ ml with correlation coefficient (n = 6) ≥ 0.9999.The molar absorptivity, Sandell sensitivity, detection and quantification limits were also calculated. The composition of the ion pairs was found 1:1 by Job's method. Conclusion: This developed method was validated for accuracy and precision and has been applied successfully for the analysis of Donepezil in pure and in its dosage forms.
Yaranal P.J.,Kannur Medical College |
Harish S.G.,Basaveshwar Medical College |
Purushotham B.,Pariyaram Medical College
Indian Journal of Cancer | Year: 2014
Introduction: Primary intestinal lymphoma (PIL) is defined as an extranodal lymphoma arising in the intestine. This study includes 11 PILs. Objectives: The objective of this study was to evaluate the clinicopathological characteristics of primary non-Hodgkin′s lymphoma (NHL) in the small and large intestine. All cases were reclassified according to the World Health Organization classification of lymphoma in 2001. Immunohistochemistry (IHC) was used to confirm the histopathological diagnosis. Materials and Methods: Eleven cases of primary non-Hodgkin in the small and large intestine were studied retrospectively in a 5 year period. There were seven cases of resected intestinal specimens and four biopsy specimens. Five cases from ileum and two cases each from caecum and duodenum and one case each from jejunum and duodenum. Hematoxylin and eosin stained sections were studied with light microscopy and IHC for CD5, 20, 21 and cyclin D1 were done. Results: It is a retrospective study of 11 cases of intestinal lymphomas. Abdominal pain and abdominal lump were two main common presenting symptoms. NHLs were more common in the small intestine. PILs are common in adults (75% above 46 years) with male preponderance. All were NHLs and B-cell type. Five cases were diffuse large B-cell lymphoma and four cases each were mucosa-associated lymphatic tissue lymphoma and follicular lymphoma. One case was lymphomatoid polyposis or mantle cell lymphoma. Conclusion: PILs is rare and differs significantly from their gastric counterpart, not only in pathology but also with regard to clinical features, management and prognosis. Due to the lack of characteristic symptoms and a low incidence rate, PIL is misdiagnosed until serious complications occur, such as perforation and bleeding and hence needs to be accurately diagnosed.
Kulkarni C.,KMC |
George T.A.,Pariyaram Medical College |
Asha A.V.,Pariyaram Medical College |
Ravindran R.,Pariyaram Medical College
Journal of Clinical and Diagnostic Research | Year: 2014
Acute angle closure glaucoma is rarely seen as complication of snake bite.We report three cases of bilateral acute angle closure glaucoma with capillary leak syndrome and acute renal failure secondary to hematotoxic snake bites. We are also briefly discussing the association of capillary leak syndrome and angle closure glaucoma in hematotoxic snake bite. This is the first time an association between angle closure and capillary leak syndrome following snake bite is reported.Study type: Descriptive case series.Materials and Methods: Records of all patients admitted to ICU with snake bite were reviewed to identify cases developing acute angle closure glaucoma. These cases with acute angle closure glaucoma are analysed in detail for systemic condition. Diagnosis, management and outcome of cases are described.Results: Of the 119 snake bites admitted, 47 patients had confirmed hematotoxic snake bite. 15 of these patients underwent hemodialysis for acute renal failure. 7 of them were diagnosed to have capillary leak syndrome and all of them complained of decreased vision. 3 of the 7 cases had acute angle closure glaucoma on the second day of bite. One of the patients expired and other two recovered fully, both of them had normal IOP and good vision at one month follow up.Conclusion: Acute angle closure glaucoma seems to be associated with systemic capillary leak syndrome in hematotoxic snake bite. High suspicion, early recognition, timely and appropriate treatment can prevent visual loss in this rare complication. © 2014, Journal of Clinical and Diagnostic Research. All rights reserved.
Indiran V.,Sree Balaji Medical College and Hospital |
Valiyakath S.,Pariyaram medical College |
Maduraimuthu P.,Sree Balaji Medical College and Hospital
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015
A large spectrum of pathologic entities including benign and malignant lesions is found in the thyroid gland. Lesions of thyroid gland represent some of the most heterogeneous abnormalities in the head and neck. The purpose of this study was to detect thyroid lesions and to differentiate between benign and malignant pathology, based on their sonographic appearance. We evaluated 90 patients with thyroid swelling using high resolution sonography and color Doppler and followed up with HPE. The present study had a sensitivity of 66.6%, specificity of 96.7% and diagnostic accuracy of 91%. The sensitivity and specificity of ultrasonography in various other studies range from 60-75% and 59-91% respectively. Such wide variation in predictive values is usually attributed to the fact of ultrasonography being highly operator dependent. High resolution sonography performed by a skilled radiologist is very sensitive and is recommended as the primary imaging modality in evaluation of thyroid diseases. It has a high sensitivity and specificity in the diagnosis of thyroid diseases. Sonography examination can be regarded as an excellent investigation for differentiating solid, cystic and mixed lesions; for locating clinically non palpable nodules and for follow up of benign thyroid nodules.
Chacko E.C.,Singapore General Hospital |
Surrun S.K.,Singapore General Hospital |
Mubarack Sani T.P.,Pariyaram Medical College |
Pappachan J.M.,Singapore General Hospital
Postgraduate Medical Journal | Year: 2010
Chronic kidney disease (CKD) has become a major public health problem worldwide over the past few decades because of the increasing prevalence of hypertension, diabetes mellitus, and elderly individuals in most countries. Chronic viral hepatitis (due to hepatitis B virus (HBV) and hepatitis C virus (HCV)) also poses significant morbidity and mortality globally. Both these viruses can cause CKD and these infections can occur as a consequence of CKD management. CKD patients acquiring HBV or HCV infection have higher morbidity and mortality rates, and the management of these infections among CKD patients with antiviral agents is associated with high rates of adverse effects. The optimal management of CKD associated with HBV and HCV is not well defined because of insufficient data from clinical trials. This review discusses the pathogenesis, clinical characteristics and management issues related to chronic viral hepatitis and CKD.
Bindurani S.,Pariyaram Medical College |
Rajiv S.,Pariyaram Medical College
International Journal of Trichology | Year: 2013
Monilethrix is a rare autosomal dominant hair shaft disorder with variable expressivity. It usually presents with short broken scalp hairs and follicular hyperkeratosis. Light microscopy of hair reveals a beaded appearance. Here, we report the case of a 32-year-old male who presented with sparse hair and follicular keratotic papules in the absence of any family history.
PubMed | Pariyaram Medical College
Type: Journal Article | Journal: Indian journal of dermatology | Year: 2015
Paraganglioma-like dermal melanocytic tumor (PDMT) is a rare subtype of benign dermal melanocytic tumor, first described in 2004. Its histopathologic features resemble those of paraganglioma, showing presence of a distinctive partitioning of the tumor into small and large packets, nests, or short cords by delicate fibrous septa (zellballen pattern). But the immunostaining characteristics are those of melanocytic lesions, as PDMT express S-100, melan A, HMB 45 and lack pancytokeratin markers. It has a benign course, although a lesion of low malignant potential cannot be excluded. We describe a case of 60-year-old female who presented with three PDMT lesions on her right leg. To the best of our knowledge this is the first case reported from India.