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Vijay Kumar J.,Panineeya Institute of Dental science | Saraswathi T.R.,Vishnu Dental College andhra Pradesh | Ranganathan K.,Ragas Dental College andhra Pradesh | Umadevi K.M.,Ragas Dental College andhra Pradesh | And 2 more authors.
Journal of Oral and Maxillofacial Pathology | Year: 2012

Aim: Sister chromatid exchange (SCE) test is a sensitive, biomarker of genotoxic substances. The present study was conducted to observe the frequency of SCEs in peripheral blood lymphocytes of 30 males with and without the habit of cigarette smoking and alcohol consumption. Materials and Methods: Subjects for this study were males aged between 25-50 years and were selected from the students, employees and the patients attending the outpatient department of Ragas dental college and Hospital, Chennai. Results: Controls, smokers, and smokers with alcohol habit were divided into two age groups as 30 years and 30 years. In controls the mean frequency of SCEs/cell in 30 years and 30 year's age group was 5.80 and 6.05, respectively. In Smokers SCEs/cell in 30 years and 30 year's age group was 7.7 and 8.8, respectively. In Smokers with alcohol habit SCEs/cell in 30 years and 30 years age group was 10.1 and 12.8, respectively. Conclusions: In this study, the duration of the smoking habit has shown a positive correlation with the mean SCE frequency. Whereas, frequency of the habit did not show any influence on the SCE levels. In smokers with alcohol habit, both the duration and frequency of their smoking habit has shown a significant effect on the SCE levels suggesting a synergistic effect of alcohol and smoking leading to excessive DNA damage. Source

Moghe G.,Panineeya Institute of Dental science andhra Pradesh | Moghe G.,Panineeya Institute of Dental science | Mauli S.,Shaheed Kartar Singh Sarabha Dental College | Thomas A.,Christian Dental College | Obed V.A.E.,Christian Medical College
Cleft Palate-Craniofacial Journal | Year: 2013

Aim: The aim of this study was the initiation of systematic data collection so as to improve the capacity for outcome measurement after cleft repair. Also, a clinical audit was done for evaluation of the process and assessment of outcomes of cleft care. Design and Setting: A questionnaire-based survey and outcome assessment was carried out over a 1-year period from March 2008 to February 2009 at the combined outpatient cleft clinic of a tertiary care center in India. Patients and Participants: Data collection (basic demographic and environmental information) was done twice a week throughout the year by students from the Department of Pediatric Dentistry, at the outpatient cleft clinic. Results: A total of 68 completed cleft lip and palate registry forms, from which all the information was available, were analyzed. There was a skewed sex ratio, with a higher preponderance of boys seeking treatment. Of affected males, 19.1% were between 2 and 5 years of age when they first reported to the cleft clinic. Surprisingly, no bilateral clefts of lip, unilateral cleft lip (right) and unilateral cleft lip and palate (right) were observed in girls. Oral health was poor in 74% of patients; among the dental referrals only 26% could be recruited for orthodontics with a reasonably good prognosis. Conclusions: Poverty, illiteracy, and superstitions prevent an average patient from India from receiving multidisciplinary cleft care. This emphasizes the need to create systems that suit the needs of our target patients. © 2013 American Cleft Palate-Craniofacial Association. Source

Moghe G.A.,Panineeya Institute of Dental science | Kaur M.S.,Panineeya Institute of Dental science | Thomas A.M.,BRS Dental College | Raseswari T.,Christian Dental College | And 2 more authors.
Journal of Indian Society of Pedodontics and Preventive Dentistry | Year: 2010

Van der Woude syndrome (VWS) (OMIM 119300) is a dominantly inherited developmental disorder that is characterized by pits and/or sinuses of the lower lip and cleft lip and/or cleft palate. Mutations in the interferon regulatory factor 6 gene (IRF6) have been recently identified in patients with VWS, with more than 60 mutations reported. We report the phenotypic variants of the syndrome in a family and present the application of the multicolor chromosome banding (mBAND) analysis in the identification of complex intrachromosome rearrangements of chromosome 9 in a child with VWS. The authors conclude that increased heterochromatin on chromosome 9 did not have any effect on the phenotypic expression of the syndrome in the family that was studied. Source

Doshi D.,Panineeya Institute of Dental science | Reddy B.S.,Panineeya Institute of Dental science | Kulkarni S.,Panineeya Institute of Dental science | Karunakar P.,Panineeya Institute of Dental science | Anup N.,Jaipur Dental College
Epilepsy and Behavior | Year: 2012

Aim: The present study was designed to assess the knowledge, attitudes and practices about epilepsy among a group of dentists in Hyderabad city, India. Materials and methods: All dentists registered with the local Dental Association branch were eligible to participate in this questionnaire study. Descriptive and Inferential Statistics were used. Multiple group analysis was done using Kruskal-Wallis, and Mann Whitney U Test was used for two-group comparison. The variables were taken as significant at a p value of 0.05. Results: A total of 217 respondents with mean age of 33.16 ± 10.4. years participated in the study. Most respondents possessed a post-graduate (Master of Dental Surgery - MDS) degree (59.4%). A convulsion or shaking was identified as the most familiar recognizable symptom of epilepsy. 84.3% of the dentists would not object to their children having association with patients with epilepsy, and 61.3% would not object to their relative marrying a person with a history of epilepsy. A large number of dentists (178; 82%) were confident to treat a person with epilepsy. 95.3% assumed that they have an ethical responsibility to treat this population. None of the practice-related questions showed any significant difference with respect to different age groups, gender or the education levels (BDS/MDS). Conclusion: Our study reflects that this group of Indian dentists has a fairly high knowledge and positive attitudes toward patients with epilepsy. This encouraging approach and confidence among dentists may positively influence patients with epilepsy to seek dental care. © 2012 Elsevier Inc. Source

Siva Prasad Reddy G.,Panineeya Institute of Dental science | Sekhar Reddy N.V.S.,Panineeya Institute of Dental science | Reddy G.V.,Panineeya Institute of Dental science | Sriharsha K.,Panineeya Institute of Dental science
Journal of Clinical and Diagnostic Research | Year: 2014

Epidermoid cysts are developmental, benign, cutaneous cysts which are commonly found on face followed by trunk and neck. They account for approximately 80% of follicular cysts of the skin. They are slow growing lesions and remain asymptomatic until or unless secondarily infected. They occasionally have tendency to develop into a malignancy. We describe a case of giant epidermoid cyst of posterior part of external ear, a location where very few cases have been reported in the literature. Since cyst was attached to the external ear, esthetics was also one of the important concern apart from the cyst getting infected, as they cause disfigurement of the face. The cyst was excised surgically. Histopathology confirmed the presumptive diagnosis of Epidermoid cyst. Two-years after the resection there was no recurrence. Due to the possibility of the cyst to transform into a malignancy and for appropriate diagnosis, histopathological examination remains a gold standard for confirmatory diagnosis. Source

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