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Pt. Ravishankar Shukla University in Raipur, is Chhattisgarh's largest and oldest institution of higher education, founded in 1964 Wikipedia.

Sahu D.K.,Indian Institute of Astrophysics | Anupama G.C.,Indian Institute of Astrophysics | Chakradhari N.K.,Pandit Ravishankar Shukla University
Monthly Notices of the Royal Astronomical Society | Year: 2013

Optical UBVRI photometry and low-resolution spectroscopy of the Type IIb supernova SN 2011dh in M51 are presented, covering the first year after the explosion. The light curve andspectral evolution are discussed. The early phase light-curve evolution of SN 2011dh is verysimilar to SN 1993J and SN 2008ax. In the late phase, however, SN 2011dh declines faster thanSN 1993J. The late phase decline in the B band is steeper than in the R and I bands, indicatingthe possibility of dust formation. With a peak V-band absolute magnitude of MV =-17.123±0.18 mag, SN 2011dh is a marginally faint type IIb event. The reddening corrected colourcurves of SN 2011dh are found to be redder than other well-studied Type IIb supernovae. Thebolometric light curve indicates ~;0.09Mȯ of 56Ni is synthesized during the explosion. TheHe I lines were detected in the spectra during the rise to maximum. The nebular spectra ofSN 2011dh show a box-shaped emission in the red wing of the [OI] 6300-6363Å feature, that is attributed to Hα emission from a shock-excited circumstellar material. The analysis ofnebular spectra indicates that ~0.2Mȯ of oxygen was ejected during the explosion. Further, the [Ca II]/[O I] line ratio in the nebular phase is ~0.7, indicating a progenitor with a mainsequence mass of 10-15Mȯ. © 2013 The Authors Published by Oxford University Press on behalf of the Royal Astronomical Society. Source

Vyas A.,Pandit Ravishankar Shukla University
Journal of Inclusion Phenomena and Macrocyclic Chemistry | Year: 2013

In the present study influence of nature of selected cyclodextrins (CDs) and of methods of preparation of drug-CD complexes on the oral bioavailability, in vitro dissolution studies and pharmacodynamic activity of a sparingly water soluble drug rosuvastatin (RVS) was investigated. Phase solubility studies were conducted to find the interaction of RVS with β-CD and its derivatives, which indicated the formation of 1:1 stoichiometric inclusion complex. The apparent stability constant (K1:1) calculated from phase solubility diagram were in the rank order of β-CD < hydroxypropyl-β- cyclodextrin (HP-β-CD) < randomly methylated-β-cyclodextrin (RM-β-CD). Equimolar drug-CD solid complexes prepared by different methods were characterized by the Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and X-ray diffractometry (XRD). FTIR study demonstrated the presence of intermolecular hydrogen bonds and ordering of the molecule between RVS and CDs in inclusion complexes. DSC and XRD analysis confirmed formation of inclusion complex by freeze dried method with HP-β-CD and RM-β-CD. Aqueous solubility and dissolution studies indicated improved dissolution rates of prepared complexes in comparison with drug alone. Moreover, CD complexes demonstrated of significant improvement in reducing total cholesterol and triglycerides levels as compared to pure drug. However the in vivo results only partially agreed with those obtained from phase solubility studies. © 2012 Springer Science+Business Media B.V. Source

Das S.,Narsee Monjee Institute of Management and Higher Studies | Suresh P.K.,Pandit Ravishankar Shukla University
Nanomedicine: Nanotechnology, Biology, and Medicine | Year: 2011

Present limitations in the management of ophthalmic fungal infections include the inability to provide long-term extraocular drug delivery without compromising intraocular structures and/or systemic drug exposure. In the present study, the potential of Eudragit RS 100 nanoparticles (NPs) as a new vehicle for the improvement of the delivery of drugs to the ocular mucosa was investigated. Amphotericin B (AmB) was chosen as a model compound because of its potential usefulness for the treatment of fungal diseases. A solvent displacement technique was used to produce AmB-loaded Eudragit NPs. These NPs had a mean size range of 150-290 nm and a zeta potential of +19-28 mV. Even after 6 months of stability study, results were unchanged, indicating the good potential for ocular application. In vitro release studies revealed that a maximum amount of drug was released within 24 hours (60%). The results obtained from microbial assay showed that the antifungal activity of drug-loaded NPs was equal to or slightly lower than that of free-AmB solution. In vivo experiments showed that, following topical instillation of nanosuspension to a rabbit's eye there was no irritation. From these results we can conclude that Eudragit RS 100 nanosuspension may represent an efficacious vehicle to deliver the drug into the eye. From the Clinical Editor: Amphotericin B encapsulated into Eudragit, a mildly cationic nanoparticle, was shown to have 6 month stability, release 60% of its drug payload in dissolution within 24 hours, and elicited no irritation when instilled into rabbit eyes. The concept is being considered for local ophthalmologic therapy of fungal disease. © 2011 Elsevier Inc. Source

Kaur C.D.,Pandit Ravishankar Shukla University | Saraf S.,Pandit Ravishankar Shukla University
Journal of Cosmetic Dermatology | Year: 2011

Background Ultraviolet radiations generate reactive oxygen species, leading to adverse effects on skin properties. Botanical extracts are multifunctional in nature having various properties like photoprotection, anti-aging, moisturizing, antioxidant, astringent, anti-irritant, and antimicrobial activity. Aims The aim of this study was to formulate creams having Curcuma longa extract loaded novel vesicular systems (liposomes, ethosomes, and transfersomes) and study their photoprotective effect by assessment of skin hydration (Cutometer) and sebum content (Sebumeter). Methods The alcoholic C. longa extract loaded liposomes, ethosomes, and transfersomes having 0.5-2.0% w/w extract were prepared, evaluated for size, entrapment efficiency, and incorporated into the cream. Their long-term interaction with skin (6weeks) was compared in terms of their effects on skin hydration and sebum content. Results Vesicular size obtained was in the range 167.3±3.0 to 262.4±2.4nm with low polydispersity index (0.2-0.3) and high entrapment efficiency. The efficacy was in the order C. longa extract loaded transfersomal creams > C. longa extract loaded ethosomal creams > C. longa extract loaded liposomal creams > C. longa extract loaded creams > Empty transfersome loaded cream > Empty ethosome loaded cream > Empty liposome loaded cream > Base cream. Conclusions The photoprotective properties of the constituents of C. longa extract and hydrant, moisturizing lipid components of nano vesicles with better skin penetration resulted in improvement in skin properties like skin hydration and sebum content. The herbal extract loaded nano vesicles incorporated in cream could be used as photoprotective formulations. © 2011 Wiley Periodicals, Inc. Source

Verma S.K.,Pandit Ravishankar Shukla University | Ghosh K.K.,Pandit Ravishankar Shukla University
Journal of Surfactants and Detergents | Year: 2011

The physicochemical and interfacial properties of the monomeric surfactants cetyltrimethyl ammonium bromide (CTAB), cetyltriphenyl phosphonium bromide (CTPB), tetradecyl triphenyl phosphonium bromide (TTPB), cetyldiethylethanol ammonium bromide (CDEEAB), cetyltrimethyl ammonium chloride (CTACl), tetradecyltrimethyl ammonium bromide (TTAB), and a gemini surfactant (C16-3-C16, 2Br-) at different pH (3.1, 7.0, and 7.75) have been investigated by conductivity and surface tension measurements at 300 K. The critical micellar concentration (CMC), degree of micellar ionization (a), surface excess concentration (Umax), minimum surface area per molecule of surfactant (Amin), Gibbs free energy of micellization (ΔGm 0 ), surface pressure at the CMC (pCMC), and the Gibbs energy of adsorption (ΔGads 0 ) of the monomeric surfactants have also been determined. The CMC, a and Umax, increase with increasing pH whereas Amin decreases. © AOCS 2011. Source

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